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Repeatability of Contrast-Enhanced Ultrasound to Determine Renal Cortical Perfusion

Alterations in renal perfusion play a major role in the pathogenesis of renal diseases. Renal contrast-enhanced ultrasound (CEUS) is increasingly applied to quantify renal cortical perfusion and to assess its change over time, but comprehensive assessment of the technique’s repeatability is lacking....

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Autores principales: Almushayt, Shatha J., Pham, Alisa, Phillips, Bethan E., Williams, John P., Taal, Maarten W., Selby, Nicholas M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141960/
https://www.ncbi.nlm.nih.gov/pubmed/35626449
http://dx.doi.org/10.3390/diagnostics12051293
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author Almushayt, Shatha J.
Pham, Alisa
Phillips, Bethan E.
Williams, John P.
Taal, Maarten W.
Selby, Nicholas M.
author_facet Almushayt, Shatha J.
Pham, Alisa
Phillips, Bethan E.
Williams, John P.
Taal, Maarten W.
Selby, Nicholas M.
author_sort Almushayt, Shatha J.
collection PubMed
description Alterations in renal perfusion play a major role in the pathogenesis of renal diseases. Renal contrast-enhanced ultrasound (CEUS) is increasingly applied to quantify renal cortical perfusion and to assess its change over time, but comprehensive assessment of the technique’s repeatability is lacking. Ten adults attended two renal CEUS scans within 14 days. In each session, five destruction/reperfusion sequences were captured. One-phase association was performed to derive the following parameters: acoustic index (AI), mean transit time (mTT), perfusion index (PI), and wash-in rate (WiR). Intra-individual and inter-operator (image analysis) repeatability for the perfusion variables were assessed using intra-class correlation (ICC), with the agreement assessed using a Bland–Altman analysis. The 10 adults had a median (IQR) age of 39 years (30–46). Good intra-individual repeatability was found for mTT (ICC: 0.71) and PI (ICC: 0.65). Lower repeatability was found for AI (ICC: 0.50) and WiR (ICC: 0.56). The correlation between the two operators was excellent for all variables: the ICCs were 0.99 for PI, 0.98 for AI, 0.87 for mTT, and 0.83 for WiR. The Bland–Altman analysis showed that the mean biases (± SD) between the two operators were 0.03 ± 0.16 for mTT, 0.005 ± 0.09 for PI, 0.04 ± 0.19 for AI, and −0.02 ± 0.11 for WiR.
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spelling pubmed-91419602022-05-28 Repeatability of Contrast-Enhanced Ultrasound to Determine Renal Cortical Perfusion Almushayt, Shatha J. Pham, Alisa Phillips, Bethan E. Williams, John P. Taal, Maarten W. Selby, Nicholas M. Diagnostics (Basel) Article Alterations in renal perfusion play a major role in the pathogenesis of renal diseases. Renal contrast-enhanced ultrasound (CEUS) is increasingly applied to quantify renal cortical perfusion and to assess its change over time, but comprehensive assessment of the technique’s repeatability is lacking. Ten adults attended two renal CEUS scans within 14 days. In each session, five destruction/reperfusion sequences were captured. One-phase association was performed to derive the following parameters: acoustic index (AI), mean transit time (mTT), perfusion index (PI), and wash-in rate (WiR). Intra-individual and inter-operator (image analysis) repeatability for the perfusion variables were assessed using intra-class correlation (ICC), with the agreement assessed using a Bland–Altman analysis. The 10 adults had a median (IQR) age of 39 years (30–46). Good intra-individual repeatability was found for mTT (ICC: 0.71) and PI (ICC: 0.65). Lower repeatability was found for AI (ICC: 0.50) and WiR (ICC: 0.56). The correlation between the two operators was excellent for all variables: the ICCs were 0.99 for PI, 0.98 for AI, 0.87 for mTT, and 0.83 for WiR. The Bland–Altman analysis showed that the mean biases (± SD) between the two operators were 0.03 ± 0.16 for mTT, 0.005 ± 0.09 for PI, 0.04 ± 0.19 for AI, and −0.02 ± 0.11 for WiR. MDPI 2022-05-23 /pmc/articles/PMC9141960/ /pubmed/35626449 http://dx.doi.org/10.3390/diagnostics12051293 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Almushayt, Shatha J.
Pham, Alisa
Phillips, Bethan E.
Williams, John P.
Taal, Maarten W.
Selby, Nicholas M.
Repeatability of Contrast-Enhanced Ultrasound to Determine Renal Cortical Perfusion
title Repeatability of Contrast-Enhanced Ultrasound to Determine Renal Cortical Perfusion
title_full Repeatability of Contrast-Enhanced Ultrasound to Determine Renal Cortical Perfusion
title_fullStr Repeatability of Contrast-Enhanced Ultrasound to Determine Renal Cortical Perfusion
title_full_unstemmed Repeatability of Contrast-Enhanced Ultrasound to Determine Renal Cortical Perfusion
title_short Repeatability of Contrast-Enhanced Ultrasound to Determine Renal Cortical Perfusion
title_sort repeatability of contrast-enhanced ultrasound to determine renal cortical perfusion
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141960/
https://www.ncbi.nlm.nih.gov/pubmed/35626449
http://dx.doi.org/10.3390/diagnostics12051293
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