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Next-Generation Probiotics for Inflammatory Bowel Disease
Engineered probiotics represent a cutting-edge therapy in intestinal inflammatory disease (IBD). Genetically modified bacteria have provided a new strategy to release therapeutically operative molecules in the intestine and have grown into promising new therapies for IBD. Current IBD treatments, suc...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141965/ https://www.ncbi.nlm.nih.gov/pubmed/35628274 http://dx.doi.org/10.3390/ijms23105466 |
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author | Pesce, Marcella Seguella, Luisa Del Re, Alessandro Lu, Jie Palenca, Irene Corpetti, Chiara Rurgo, Sara Sanseverino, Walter Sarnelli, Giovanni Esposito, Giuseppe |
author_facet | Pesce, Marcella Seguella, Luisa Del Re, Alessandro Lu, Jie Palenca, Irene Corpetti, Chiara Rurgo, Sara Sanseverino, Walter Sarnelli, Giovanni Esposito, Giuseppe |
author_sort | Pesce, Marcella |
collection | PubMed |
description | Engineered probiotics represent a cutting-edge therapy in intestinal inflammatory disease (IBD). Genetically modified bacteria have provided a new strategy to release therapeutically operative molecules in the intestine and have grown into promising new therapies for IBD. Current IBD treatments, such as corticosteroids and immunosuppressants, are associated with relevant side effects and a significant proportion of patients are dependent on these therapies, thus exposing them to the risk of relevant long-term side effects. Discovering new and effective therapeutic strategies is a worldwide goal in this research field and engineered probiotics could potentially provide a viable solution. This review aims at describing the proceeding of bacterial engineering and how genetically modified probiotics may represent a promising new biotechnological approach in IBD treatment. |
format | Online Article Text |
id | pubmed-9141965 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91419652022-05-28 Next-Generation Probiotics for Inflammatory Bowel Disease Pesce, Marcella Seguella, Luisa Del Re, Alessandro Lu, Jie Palenca, Irene Corpetti, Chiara Rurgo, Sara Sanseverino, Walter Sarnelli, Giovanni Esposito, Giuseppe Int J Mol Sci Review Engineered probiotics represent a cutting-edge therapy in intestinal inflammatory disease (IBD). Genetically modified bacteria have provided a new strategy to release therapeutically operative molecules in the intestine and have grown into promising new therapies for IBD. Current IBD treatments, such as corticosteroids and immunosuppressants, are associated with relevant side effects and a significant proportion of patients are dependent on these therapies, thus exposing them to the risk of relevant long-term side effects. Discovering new and effective therapeutic strategies is a worldwide goal in this research field and engineered probiotics could potentially provide a viable solution. This review aims at describing the proceeding of bacterial engineering and how genetically modified probiotics may represent a promising new biotechnological approach in IBD treatment. MDPI 2022-05-13 /pmc/articles/PMC9141965/ /pubmed/35628274 http://dx.doi.org/10.3390/ijms23105466 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pesce, Marcella Seguella, Luisa Del Re, Alessandro Lu, Jie Palenca, Irene Corpetti, Chiara Rurgo, Sara Sanseverino, Walter Sarnelli, Giovanni Esposito, Giuseppe Next-Generation Probiotics for Inflammatory Bowel Disease |
title | Next-Generation Probiotics for Inflammatory Bowel Disease |
title_full | Next-Generation Probiotics for Inflammatory Bowel Disease |
title_fullStr | Next-Generation Probiotics for Inflammatory Bowel Disease |
title_full_unstemmed | Next-Generation Probiotics for Inflammatory Bowel Disease |
title_short | Next-Generation Probiotics for Inflammatory Bowel Disease |
title_sort | next-generation probiotics for inflammatory bowel disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141965/ https://www.ncbi.nlm.nih.gov/pubmed/35628274 http://dx.doi.org/10.3390/ijms23105466 |
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