Cargando…

The Val34Met, Thr164Ile and Ser220Cys Polymorphisms of the β2-Adrenergic Receptor and Their Consequences on the Receptor Conformational Features: A Molecular Dynamics Simulation Study

The gene encoding the β2-adrenergic receptor (β2-AR) is polymorphic, which results in possible differences in a primary structure of this protein. It has been shown that certain types of polymorphisms are correlated with some clinical features of asthma, including airways reactivity, whereas the inf...

Descripción completa

Detalles Bibliográficos
Autores principales:	Archala, Aneta, Plazinski, Wojciech, Plazinska, Anita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141972/ https://www.ncbi.nlm.nih.gov/pubmed/35628258 http://dx.doi.org/10.3390/ijms23105449

Ejemplares similares

Agonist binding by the β(2)-adrenergic receptor: an effect of receptor conformation on ligand association–dissociation characteristics
por: Plazinska, Anita, et al.
Publicado: (2015)

Association between the Ile164 β2 Adrenergic Receptor Polymorphism and Fatigue in Patients with Rheumatoid Arthritis
por: Philipp, Julian, et al.
Publicado: (2023)

The desoxazoline asidiacyclamide analogue cyclo(Gly–Thr–D-Val–Thz–Ile–Thr–D-Val–Thz) acetonitrile monosolvate
por: Asano, Akiko, et al.
Publicado: (2011)

Consensus interpretation of the p.Met34Thr and p.Val37Ile variants in GJB2 by the ClinGen Hearing Loss Expert Panel
por: Shen, Jun, et al.
Publicado: (2019)

Synthesis of Novel 2-(Cyclopentylamino)thiazol-4(5H)-one Derivatives with Potential Anticancer, Antioxidant, and 11β-HSD Inhibitory Activities
por: Baumgart, Szymon, et al.
Publicado: (2023)

Common polymorphism (81Val>Ile) and rare mutations (257Arg>Ser and 335Ile>Ser) of the MC3R gene in obese Polish children and adolescents
por: Cieslak, J., et al.
Publicado: (2013)

Catalytic Thr or Ser Residue Modulates Structural Switches in 2-Cys Peroxiredoxin by Distinct Mechanisms
por: Tairum, Carlos A., et al.
Publicado: (2016)

Distribution and dissemination of the Val1016Ile and Phe1534Cys Kdr mutations in Aedes aegypti Brazilian natural populations
por: Linss, Jutta Gerlinde Birggitt, et al.
Publicado: (2014)

Síncope como Expressão Fenotípica da Amiloidose Hereditária por Transtirretina Val142Ile (Val122Ile)
por: Nunes, Nágela S. V., et al.
Publicado: (2020)

Phenotypes Associated With the Val122Ile, Leu58His, and Late-Onset Val30Met Variants in Patients With Hereditary Transthyretin Amyloidosis
por: Zampino, Serena, et al.
Publicado: (2023)

Congenital erythropoietic porphyria with two mutations of the uroporphyrinogen III synthase gene (Cys73Arg, Thr228Met)
por: Gucev, Zoran, et al.
Publicado: (2011)

Val103Ile polymorphism of the melanocortin-4 receptor gene (MC4R) in cancer cachexia
por: Knoll, Susanne, et al.
Publicado: (2008)

Circles within circles: crosstalk between protein Ser/Thr/Tyr-phosphorylation and Met oxidation
por: Rao, R Shyama Prasad, et al.
Publicado: (2013)

Cardiac Findings and Events Observed in an Open-Label Clinical Trial of Tafamidis in Patients with non-Val30Met and non-Val122Ile Hereditary Transthyretin Amyloidosis
por: Damy, Thibaud, et al.
Publicado: (2015)

Absence of the toll-like receptor 4 gene polymorphisms Asp299Gly and Thr399Ile in Singaporean Chinese
por: Liang, Xiao Hui, et al.
Publicado: (2005)

Toll-like receptor 4 single-nucleotide polymorphisms Asp299Gly and Thr399Ile in ovarian cancers
por: WANG, AN-CONG, et al.
Publicado: (2014)

Molecular dynamic simulations reveal suboptimal binding of salbutamol in T164I variant of β2 adrenergic receptor
por: Bandaru, Srinivas, et al.
Publicado: (2017)

Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms: New data and a meta-analysis
por: Senhaji, Nezha, et al.
Publicado: (2014)

The Toll-Like Receptor 4 Polymorphism Asp299Gly but Not Thr399Ile Influences TLR4 Signaling and Function
por: Long, Huaicong, et al.
Publicado: (2014)

Role of Thr399Ile and Asp299Gly polymorphisms of toll-like receptor-4 gene in acute dental abscess
por: Miri-Moghaddam, Ebrahim, et al.
Publicado: (2017)

Epidermal Growth Factor Receptor Phosphorylation Sites Ser(991) and Tyr(998) Are Implicated in the Regulation of Receptor Endocytosis and Phosphorylations at Ser(1039) and Thr(1041)
por: Tong, Jiefei, et al.
Publicado: (2009)

Assignment of the Ile, Leu, Val, Met and Ala methyl group resonances of the DEAD-box RNA helicase DbpA from E. coli
por: Wurm, Jan Philip
Publicado: (2020)

Functional analysis of the BRI1 receptor kinase by Thr-for-Ser substitution in a regulatory autophosphorylation site
por: Oh, Man-Ho, et al.
Publicado: (2015)

Monocytes Heterozygous for the Asp299Gly and Thr399Ile Mutations in the Toll-like Receptor 4 Gene Show No Deficit in Lipopolysaccharide Signalling
por: Erridge, Clett, et al.
Publicado: (2003)

Toll-like receptor 4 single-nucleotide polymorphisms Asp299Gly and Thr399Ile in head and neck squamous cell carcinomas
por: Bergmann, Christoph, et al.
Publicado: (2011)

Complete assignment of Ala, Ile, Leu(ProS), Met and Val(ProS) methyl groups of the protruding domain from human norovirus GII.4 Saga
por: Müller-Hermes, Christoph, et al.
Publicado: (2020)

Rarity of TLR4 Asp299Gly and Thr399Ile Polymorphisms in the Korean Population
por: Kim, Yeun Sun, et al.
Publicado: (2008)

Association of the TBK1 mutation p.Ile334Thr with frontotemporal dementia and literature review
por: Yu, Huiling, et al.
Publicado: (2019)

Plasma urotensin-2 level and Thr21Met but not Ser89Asn polymorphisms of the urotensin-2 gene are associated with migraines
por: Geyik, Sırma, et al.
Publicado: (2016)

Molecular Basis for Ser/Thr Specificity in PKA Signaling
por: Knape, Matthias J., et al.
Publicado: (2020)

Absence of Common Polymorphisms of Toll Like Receptor 4 (TLR4): Asp299Gly, Thr399Ile in Patients with Gastroduodenal Diseases in Japan
por: Tahara, Tomomitsu, et al.
Publicado: (2007)

Sex-specific effect of CPB2 Ala147Thr but not Thr325Ile variants on the risk of venous thrombosis: A comprehensive meta-analysis
por: Zwingerman, Nora, et al.
Publicado: (2017)

The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritis
por: Valdes, Ana M, et al.
Publicado: (2011)

HER2 Ile655Val Single Nucleotide Polymorphism in Patients with Ovarian Cancer
por: Mojtahedi, Zahra, et al.
Publicado: (2013)

MLH1 Ile219Val Polymorphism in Argentinean Families with Suspected Lynch Syndrome
por: Dominguez-Valentin, Mev, et al.
Publicado: (2016)

Reclassification of the BRAF p.Ile208Val variant by case-level data sharing
por: Grant, Andrew R., et al.
Publicado: (2018)

Molecular interactions between fenoterol stereoisomers and derivatives and the β(2)-adrenergic receptor binding site studied by docking and molecular dynamics simulations
por: Plazinska, Anita, et al.
Publicado: (2013)

Cardiac β(2)-Adrenergic Receptor Phosphorylation at Ser(355/356) Regulates Receptor Internalization and Functional Resensitization
por: Fan, Xiaofang, et al.
Publicado: (2016)

Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies
por: Nishizawa, Daisuke, et al.
Publicado: (2015)

Contribution of Val/Ile87 residue in the extracellular domain in agonist-induced current responses of the human and rat P2X7 receptors
por: Caseley, Emily A, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_171ibfu2bt7prf6cdhdegv2tas