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USP10 as a Potential Therapeutic Target in Human Cancers

Deubiquitination is a major form of post-translational protein modification involved in the regulation of protein homeostasis and various cellular processes. Deubiquitinating enzymes (DUBs), comprising about five subfamily members, are key players in deubiquitination. USP10 is a USP-family DUB featu...

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Autores principales: Tao, Li, Liu, Xiao, Jiang, Xinya, Zhang, Kun, Wang, Yijing, Li, Xiumin, Jiang, Shulong, Han, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142050/
https://www.ncbi.nlm.nih.gov/pubmed/35627217
http://dx.doi.org/10.3390/genes13050831
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author Tao, Li
Liu, Xiao
Jiang, Xinya
Zhang, Kun
Wang, Yijing
Li, Xiumin
Jiang, Shulong
Han, Tao
author_facet Tao, Li
Liu, Xiao
Jiang, Xinya
Zhang, Kun
Wang, Yijing
Li, Xiumin
Jiang, Shulong
Han, Tao
author_sort Tao, Li
collection PubMed
description Deubiquitination is a major form of post-translational protein modification involved in the regulation of protein homeostasis and various cellular processes. Deubiquitinating enzymes (DUBs), comprising about five subfamily members, are key players in deubiquitination. USP10 is a USP-family DUB featuring the classic USP domain, which performs deubiquitination. Emerging evidence has demonstrated that USP10 is a double-edged sword in human cancers. However, the precise molecular mechanisms underlying its different effects in tumorigenesis remain elusive. A possible reason is dependence on the cell context. In this review, we summarize the downstream substrates and upstream regulators of USP10 as well as its dual role as an oncogene and tumor suppressor in various human cancers. Furthermore, we summarize multiple pharmacological USP10 inhibitors, including small-molecule inhibitors, such as spautin-1, and traditional Chinese medicines. Taken together, the development of specific and efficient USP10 inhibitors based on USP10’s oncogenic role and for different cancer types could be a promising therapeutic strategy.
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spelling pubmed-91420502022-05-28 USP10 as a Potential Therapeutic Target in Human Cancers Tao, Li Liu, Xiao Jiang, Xinya Zhang, Kun Wang, Yijing Li, Xiumin Jiang, Shulong Han, Tao Genes (Basel) Review Deubiquitination is a major form of post-translational protein modification involved in the regulation of protein homeostasis and various cellular processes. Deubiquitinating enzymes (DUBs), comprising about five subfamily members, are key players in deubiquitination. USP10 is a USP-family DUB featuring the classic USP domain, which performs deubiquitination. Emerging evidence has demonstrated that USP10 is a double-edged sword in human cancers. However, the precise molecular mechanisms underlying its different effects in tumorigenesis remain elusive. A possible reason is dependence on the cell context. In this review, we summarize the downstream substrates and upstream regulators of USP10 as well as its dual role as an oncogene and tumor suppressor in various human cancers. Furthermore, we summarize multiple pharmacological USP10 inhibitors, including small-molecule inhibitors, such as spautin-1, and traditional Chinese medicines. Taken together, the development of specific and efficient USP10 inhibitors based on USP10’s oncogenic role and for different cancer types could be a promising therapeutic strategy. MDPI 2022-05-06 /pmc/articles/PMC9142050/ /pubmed/35627217 http://dx.doi.org/10.3390/genes13050831 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tao, Li
Liu, Xiao
Jiang, Xinya
Zhang, Kun
Wang, Yijing
Li, Xiumin
Jiang, Shulong
Han, Tao
USP10 as a Potential Therapeutic Target in Human Cancers
title USP10 as a Potential Therapeutic Target in Human Cancers
title_full USP10 as a Potential Therapeutic Target in Human Cancers
title_fullStr USP10 as a Potential Therapeutic Target in Human Cancers
title_full_unstemmed USP10 as a Potential Therapeutic Target in Human Cancers
title_short USP10 as a Potential Therapeutic Target in Human Cancers
title_sort usp10 as a potential therapeutic target in human cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142050/
https://www.ncbi.nlm.nih.gov/pubmed/35627217
http://dx.doi.org/10.3390/genes13050831
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