Cargando…
Comparative Study of Algae-Based Measurements of the Toxicity of 14 Manufactured Nanomaterials
With the increasing use of nanomaterials in recent years, determining their comparative toxicities has become a subject of intense research interest. However, the variety of test methods available for each material makes it difficult to compare toxicities. Here, an accurate and reliable method is de...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142051/ https://www.ncbi.nlm.nih.gov/pubmed/35627388 http://dx.doi.org/10.3390/ijerph19105853 |
_version_ | 1784715488962543616 |
---|---|
author | Lee, Seung-Hun Jung, Kiyoon Chung, Jinwook Lee, Yong-Woo |
author_facet | Lee, Seung-Hun Jung, Kiyoon Chung, Jinwook Lee, Yong-Woo |
author_sort | Lee, Seung-Hun |
collection | PubMed |
description | With the increasing use of nanomaterials in recent years, determining their comparative toxicities has become a subject of intense research interest. However, the variety of test methods available for each material makes it difficult to compare toxicities. Here, an accurate and reliable method is developed to evaluate the toxicity of manufactured nanomaterials, such as Al(2)O(3), carbon black, single-walled carbon nanotubes (SWCNTs), multi-walled carbon nanotubes (MWCNTs), CeO(2), dendrimers, fullerene, gold, iron, nanoclays, silver, SiO(2), TiO(2), and ZnO. A series of 72 h chronic and 8 h acute toxicity tests was performed using cell counting, chlorophyll, and delayed fluorescence methods. Comparable toxicities using the chlorophyll and delayed fluorescence methods were impossible to determine because the EC(50) of some of the nanomaterials could not be measured. All three test methods were successfully applied to the chronic toxicity tests of manufactured nanomaterials, and cell counting was the only method applicable to acute toxicity tests. The toxicity data and the proposal of measurement method for manufactured nanomaterials obtained in this study can be helpful for preparing exposure standards and investigating the toxicities of other nanomaterials in the future. |
format | Online Article Text |
id | pubmed-9142051 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91420512022-05-28 Comparative Study of Algae-Based Measurements of the Toxicity of 14 Manufactured Nanomaterials Lee, Seung-Hun Jung, Kiyoon Chung, Jinwook Lee, Yong-Woo Int J Environ Res Public Health Article With the increasing use of nanomaterials in recent years, determining their comparative toxicities has become a subject of intense research interest. However, the variety of test methods available for each material makes it difficult to compare toxicities. Here, an accurate and reliable method is developed to evaluate the toxicity of manufactured nanomaterials, such as Al(2)O(3), carbon black, single-walled carbon nanotubes (SWCNTs), multi-walled carbon nanotubes (MWCNTs), CeO(2), dendrimers, fullerene, gold, iron, nanoclays, silver, SiO(2), TiO(2), and ZnO. A series of 72 h chronic and 8 h acute toxicity tests was performed using cell counting, chlorophyll, and delayed fluorescence methods. Comparable toxicities using the chlorophyll and delayed fluorescence methods were impossible to determine because the EC(50) of some of the nanomaterials could not be measured. All three test methods were successfully applied to the chronic toxicity tests of manufactured nanomaterials, and cell counting was the only method applicable to acute toxicity tests. The toxicity data and the proposal of measurement method for manufactured nanomaterials obtained in this study can be helpful for preparing exposure standards and investigating the toxicities of other nanomaterials in the future. MDPI 2022-05-11 /pmc/articles/PMC9142051/ /pubmed/35627388 http://dx.doi.org/10.3390/ijerph19105853 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lee, Seung-Hun Jung, Kiyoon Chung, Jinwook Lee, Yong-Woo Comparative Study of Algae-Based Measurements of the Toxicity of 14 Manufactured Nanomaterials |
title | Comparative Study of Algae-Based Measurements of the Toxicity of 14 Manufactured Nanomaterials |
title_full | Comparative Study of Algae-Based Measurements of the Toxicity of 14 Manufactured Nanomaterials |
title_fullStr | Comparative Study of Algae-Based Measurements of the Toxicity of 14 Manufactured Nanomaterials |
title_full_unstemmed | Comparative Study of Algae-Based Measurements of the Toxicity of 14 Manufactured Nanomaterials |
title_short | Comparative Study of Algae-Based Measurements of the Toxicity of 14 Manufactured Nanomaterials |
title_sort | comparative study of algae-based measurements of the toxicity of 14 manufactured nanomaterials |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142051/ https://www.ncbi.nlm.nih.gov/pubmed/35627388 http://dx.doi.org/10.3390/ijerph19105853 |
work_keys_str_mv | AT leeseunghun comparativestudyofalgaebasedmeasurementsofthetoxicityof14manufacturednanomaterials AT jungkiyoon comparativestudyofalgaebasedmeasurementsofthetoxicityof14manufacturednanomaterials AT chungjinwook comparativestudyofalgaebasedmeasurementsofthetoxicityof14manufacturednanomaterials AT leeyongwoo comparativestudyofalgaebasedmeasurementsofthetoxicityof14manufacturednanomaterials |