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Transmission Distortion of MCT1 rs1049434 among Polish Elite Athletes

Background: To date, nearly 300 genetic markers were linked to endurance and power/strength traits. The current study aimed to compare genotype distributions and allele frequencies of the common polymorphisms: MCT1 rs1049434, NRF2 rs12594956, MYBPC3 rs1052373 and HFE rs1799945 in Polish elite athlet...

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Autores principales: Dzitkowska-Zabielska, Magdalena, Bojarczuk, Aleksandra, Borczyk, Małgorzata, Piechota, Marcin, Korostyński, Michał, Adamczyk, Jakub Grzegorz, Trybek, Grzegorz, Massidda, Myosotis, Cięszczyk, Paweł
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142056/
https://www.ncbi.nlm.nih.gov/pubmed/35627255
http://dx.doi.org/10.3390/genes13050870
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author Dzitkowska-Zabielska, Magdalena
Bojarczuk, Aleksandra
Borczyk, Małgorzata
Piechota, Marcin
Korostyński, Michał
Adamczyk, Jakub Grzegorz
Trybek, Grzegorz
Massidda, Myosotis
Cięszczyk, Paweł
author_facet Dzitkowska-Zabielska, Magdalena
Bojarczuk, Aleksandra
Borczyk, Małgorzata
Piechota, Marcin
Korostyński, Michał
Adamczyk, Jakub Grzegorz
Trybek, Grzegorz
Massidda, Myosotis
Cięszczyk, Paweł
author_sort Dzitkowska-Zabielska, Magdalena
collection PubMed
description Background: To date, nearly 300 genetic markers were linked to endurance and power/strength traits. The current study aimed to compare genotype distributions and allele frequencies of the common polymorphisms: MCT1 rs1049434, NRF2 rs12594956, MYBPC3 rs1052373 and HFE rs1799945 in Polish elite athletes versus nonathletes. Methods: The study involved 101 male elite Polish athletes and 41 healthy individuals from the Polish population as a control group. SNP data were extracted from whole-genome sequencing (WGS) performed using the following parameters: paired reads of 150 bps, at least 90 Gb of data per sample with 300 M reads and 30× mean coverage. Results: All the analyzed polymorphisms conformed to Hardy–Weinberg equilibrium (HWE) in athletes and the control group, except the MCT1 rs1049434, where allele T was over-represented in the elite trainers’ group. No significant between-group differences were found for analyzed polymorphisms. Conclusions: The MCT1 rs1049434 transmission distortion might be characteristic of Polish athletes and the effect of strict inclusion criteria. This result and the lack of statistically significant changes in the frequency of other polymorphisms between the groups might result from the small group size.
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spelling pubmed-91420562022-05-28 Transmission Distortion of MCT1 rs1049434 among Polish Elite Athletes Dzitkowska-Zabielska, Magdalena Bojarczuk, Aleksandra Borczyk, Małgorzata Piechota, Marcin Korostyński, Michał Adamczyk, Jakub Grzegorz Trybek, Grzegorz Massidda, Myosotis Cięszczyk, Paweł Genes (Basel) Article Background: To date, nearly 300 genetic markers were linked to endurance and power/strength traits. The current study aimed to compare genotype distributions and allele frequencies of the common polymorphisms: MCT1 rs1049434, NRF2 rs12594956, MYBPC3 rs1052373 and HFE rs1799945 in Polish elite athletes versus nonathletes. Methods: The study involved 101 male elite Polish athletes and 41 healthy individuals from the Polish population as a control group. SNP data were extracted from whole-genome sequencing (WGS) performed using the following parameters: paired reads of 150 bps, at least 90 Gb of data per sample with 300 M reads and 30× mean coverage. Results: All the analyzed polymorphisms conformed to Hardy–Weinberg equilibrium (HWE) in athletes and the control group, except the MCT1 rs1049434, where allele T was over-represented in the elite trainers’ group. No significant between-group differences were found for analyzed polymorphisms. Conclusions: The MCT1 rs1049434 transmission distortion might be characteristic of Polish athletes and the effect of strict inclusion criteria. This result and the lack of statistically significant changes in the frequency of other polymorphisms between the groups might result from the small group size. MDPI 2022-05-12 /pmc/articles/PMC9142056/ /pubmed/35627255 http://dx.doi.org/10.3390/genes13050870 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dzitkowska-Zabielska, Magdalena
Bojarczuk, Aleksandra
Borczyk, Małgorzata
Piechota, Marcin
Korostyński, Michał
Adamczyk, Jakub Grzegorz
Trybek, Grzegorz
Massidda, Myosotis
Cięszczyk, Paweł
Transmission Distortion of MCT1 rs1049434 among Polish Elite Athletes
title Transmission Distortion of MCT1 rs1049434 among Polish Elite Athletes
title_full Transmission Distortion of MCT1 rs1049434 among Polish Elite Athletes
title_fullStr Transmission Distortion of MCT1 rs1049434 among Polish Elite Athletes
title_full_unstemmed Transmission Distortion of MCT1 rs1049434 among Polish Elite Athletes
title_short Transmission Distortion of MCT1 rs1049434 among Polish Elite Athletes
title_sort transmission distortion of mct1 rs1049434 among polish elite athletes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142056/
https://www.ncbi.nlm.nih.gov/pubmed/35627255
http://dx.doi.org/10.3390/genes13050870
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