Cargando…

The Prevalence of High-Risk Prescribing of Oral Non-Steroidal Anti-Inflammatory Drugs in Primary Healthcare: A Single-Centre Retrospective Chart Review Study

The quality and safety of prescribed drugs can be assessed using prescribing safety indicators (PSIs). This study aimed to estimate the prevalence of PSIs of oral non-steroidal anti-inflammatory drugs (NSAIDs) at primary care clinics of a tertiary care hospital in Saudi Arabia and to identify the ri...

Descripción completa

Detalles Bibliográficos
Autores principales: Assiri, Ghadah Asaad, Alanazi, Bashayr Mohammed, AlRuthia, Yazed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142064/
https://www.ncbi.nlm.nih.gov/pubmed/35628004
http://dx.doi.org/10.3390/healthcare10050867
_version_ 1784715492182720512
author Assiri, Ghadah Asaad
Alanazi, Bashayr Mohammed
AlRuthia, Yazed
author_facet Assiri, Ghadah Asaad
Alanazi, Bashayr Mohammed
AlRuthia, Yazed
author_sort Assiri, Ghadah Asaad
collection PubMed
description The quality and safety of prescribed drugs can be assessed using prescribing safety indicators (PSIs). This study aimed to estimate the prevalence of PSIs of oral non-steroidal anti-inflammatory drugs (NSAIDs) at primary care clinics of a tertiary care hospital in Saudi Arabia and to identify the risk factors associated with positive PSIs for patients. In this retrospective chart review study, data from the medical records of 450 patients aged ≥18 years, who were prescribed oral NSAIDs, were reviewed and collected manually. Seven PSIs were chosen and defined as follows: prescription of an oral NSAID to any patient with a peptic ulcer; aged ≥75 years; aged ≥65 years with a glomerular filtration rate <60; heart failure; co-prescribed warfarin; co-prescribed aspirin or clopidogrel; or co-prescribed angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker and a diuretic. Patients with positive indicators are at risk of harm from high-risk prescribing. The overall period prevalence of PSIs is 153/450 (34%; 95% CI 29.60–38.39). The overall proportion of PSIs is 202/431 (46.9%; 95% CI 42.12–51.61). The most common safety indicators were for NSAIDs prescribed to patients with heart failure and patients aged ≥65 years with a glomerular filtration rate <60. The elderly and patients using polypharmacy are at increased risk of having at least one positive PSI (OR 5.22; 95% CI 3.32–8.21, p-value < 0.001 and OR 2.97; 95% CI 1.17–7.55, p-value 0.022, respectively). Patients at risk of harm from high-risk NSAID prescriptions are common in primary care. The elderly and patients on polypharmacy are at increased risk of having at least one positive PSI. Therefore, when NSAIDs are prescribed, it is recommended to weigh the benefits versus the risks for high-risk patients, such as the elderly and those with multiple-drug therapy.
format Online
Article
Text
id pubmed-9142064
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-91420642022-05-28 The Prevalence of High-Risk Prescribing of Oral Non-Steroidal Anti-Inflammatory Drugs in Primary Healthcare: A Single-Centre Retrospective Chart Review Study Assiri, Ghadah Asaad Alanazi, Bashayr Mohammed AlRuthia, Yazed Healthcare (Basel) Article The quality and safety of prescribed drugs can be assessed using prescribing safety indicators (PSIs). This study aimed to estimate the prevalence of PSIs of oral non-steroidal anti-inflammatory drugs (NSAIDs) at primary care clinics of a tertiary care hospital in Saudi Arabia and to identify the risk factors associated with positive PSIs for patients. In this retrospective chart review study, data from the medical records of 450 patients aged ≥18 years, who were prescribed oral NSAIDs, were reviewed and collected manually. Seven PSIs were chosen and defined as follows: prescription of an oral NSAID to any patient with a peptic ulcer; aged ≥75 years; aged ≥65 years with a glomerular filtration rate <60; heart failure; co-prescribed warfarin; co-prescribed aspirin or clopidogrel; or co-prescribed angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker and a diuretic. Patients with positive indicators are at risk of harm from high-risk prescribing. The overall period prevalence of PSIs is 153/450 (34%; 95% CI 29.60–38.39). The overall proportion of PSIs is 202/431 (46.9%; 95% CI 42.12–51.61). The most common safety indicators were for NSAIDs prescribed to patients with heart failure and patients aged ≥65 years with a glomerular filtration rate <60. The elderly and patients using polypharmacy are at increased risk of having at least one positive PSI (OR 5.22; 95% CI 3.32–8.21, p-value < 0.001 and OR 2.97; 95% CI 1.17–7.55, p-value 0.022, respectively). Patients at risk of harm from high-risk NSAID prescriptions are common in primary care. The elderly and patients on polypharmacy are at increased risk of having at least one positive PSI. Therefore, when NSAIDs are prescribed, it is recommended to weigh the benefits versus the risks for high-risk patients, such as the elderly and those with multiple-drug therapy. MDPI 2022-05-07 /pmc/articles/PMC9142064/ /pubmed/35628004 http://dx.doi.org/10.3390/healthcare10050867 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Assiri, Ghadah Asaad
Alanazi, Bashayr Mohammed
AlRuthia, Yazed
The Prevalence of High-Risk Prescribing of Oral Non-Steroidal Anti-Inflammatory Drugs in Primary Healthcare: A Single-Centre Retrospective Chart Review Study
title The Prevalence of High-Risk Prescribing of Oral Non-Steroidal Anti-Inflammatory Drugs in Primary Healthcare: A Single-Centre Retrospective Chart Review Study
title_full The Prevalence of High-Risk Prescribing of Oral Non-Steroidal Anti-Inflammatory Drugs in Primary Healthcare: A Single-Centre Retrospective Chart Review Study
title_fullStr The Prevalence of High-Risk Prescribing of Oral Non-Steroidal Anti-Inflammatory Drugs in Primary Healthcare: A Single-Centre Retrospective Chart Review Study
title_full_unstemmed The Prevalence of High-Risk Prescribing of Oral Non-Steroidal Anti-Inflammatory Drugs in Primary Healthcare: A Single-Centre Retrospective Chart Review Study
title_short The Prevalence of High-Risk Prescribing of Oral Non-Steroidal Anti-Inflammatory Drugs in Primary Healthcare: A Single-Centre Retrospective Chart Review Study
title_sort prevalence of high-risk prescribing of oral non-steroidal anti-inflammatory drugs in primary healthcare: a single-centre retrospective chart review study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142064/
https://www.ncbi.nlm.nih.gov/pubmed/35628004
http://dx.doi.org/10.3390/healthcare10050867
work_keys_str_mv AT assirighadahasaad theprevalenceofhighriskprescribingoforalnonsteroidalantiinflammatorydrugsinprimaryhealthcareasinglecentreretrospectivechartreviewstudy
AT alanazibashayrmohammed theprevalenceofhighriskprescribingoforalnonsteroidalantiinflammatorydrugsinprimaryhealthcareasinglecentreretrospectivechartreviewstudy
AT alruthiayazed theprevalenceofhighriskprescribingoforalnonsteroidalantiinflammatorydrugsinprimaryhealthcareasinglecentreretrospectivechartreviewstudy
AT assirighadahasaad prevalenceofhighriskprescribingoforalnonsteroidalantiinflammatorydrugsinprimaryhealthcareasinglecentreretrospectivechartreviewstudy
AT alanazibashayrmohammed prevalenceofhighriskprescribingoforalnonsteroidalantiinflammatorydrugsinprimaryhealthcareasinglecentreretrospectivechartreviewstudy
AT alruthiayazed prevalenceofhighriskprescribingoforalnonsteroidalantiinflammatorydrugsinprimaryhealthcareasinglecentreretrospectivechartreviewstudy