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Recent Advances in Epigenetics of Age-Related Kidney Diseases

Renal aging has attracted increasing attention in today’s aging society, as elderly people with advanced age are more susceptible to various kidney disorders such as acute kidney injury (AKI) and chronic kidney disease (CKD). There is no clear-cut universal mechanism for identifying age-related kidn...

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Autores principales: Liu, Feng, Chen, Jiefang, Li, Zhenqiong, Meng, Xianfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142069/
https://www.ncbi.nlm.nih.gov/pubmed/35627181
http://dx.doi.org/10.3390/genes13050796
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author Liu, Feng
Chen, Jiefang
Li, Zhenqiong
Meng, Xianfang
author_facet Liu, Feng
Chen, Jiefang
Li, Zhenqiong
Meng, Xianfang
author_sort Liu, Feng
collection PubMed
description Renal aging has attracted increasing attention in today’s aging society, as elderly people with advanced age are more susceptible to various kidney disorders such as acute kidney injury (AKI) and chronic kidney disease (CKD). There is no clear-cut universal mechanism for identifying age-related kidney diseases, and therefore, they pose a considerable medical and public health challenge. Epigenetics refers to the study of heritable modifications in the regulation of gene expression that do not require changes in the underlying genomic DNA sequence. A variety of epigenetic modifiers such as histone deacetylases (HDAC) inhibitors and DNA methyltransferase (DNMT) inhibitors have been proposed as potential biomarkers and therapeutic targets in numerous fields including cardiovascular diseases, immune system disease, nervous system diseases, and neoplasms. Accumulating evidence in recent years indicates that epigenetic modifications have been implicated in renal aging. However, no previous systematic review has been performed to systematically generalize the relationship between epigenetics and age-related kidney diseases. In this review, we aim to summarize the recent advances in epigenetic mechanisms of age-related kidney diseases as well as discuss the application of epigenetic modifiers as potential biomarkers and therapeutic targets in the field of age-related kidney diseases. In summary, the main types of epigenetic processes including DNA methylation, histone modifications, non-coding RNA (ncRNA) modulation have all been implicated in the progression of age-related kidney diseases, and therapeutic targeting of these processes will yield novel therapeutic strategies for the prevention and/or treatment of age-related kidney diseases.
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spelling pubmed-91420692022-05-28 Recent Advances in Epigenetics of Age-Related Kidney Diseases Liu, Feng Chen, Jiefang Li, Zhenqiong Meng, Xianfang Genes (Basel) Review Renal aging has attracted increasing attention in today’s aging society, as elderly people with advanced age are more susceptible to various kidney disorders such as acute kidney injury (AKI) and chronic kidney disease (CKD). There is no clear-cut universal mechanism for identifying age-related kidney diseases, and therefore, they pose a considerable medical and public health challenge. Epigenetics refers to the study of heritable modifications in the regulation of gene expression that do not require changes in the underlying genomic DNA sequence. A variety of epigenetic modifiers such as histone deacetylases (HDAC) inhibitors and DNA methyltransferase (DNMT) inhibitors have been proposed as potential biomarkers and therapeutic targets in numerous fields including cardiovascular diseases, immune system disease, nervous system diseases, and neoplasms. Accumulating evidence in recent years indicates that epigenetic modifications have been implicated in renal aging. However, no previous systematic review has been performed to systematically generalize the relationship between epigenetics and age-related kidney diseases. In this review, we aim to summarize the recent advances in epigenetic mechanisms of age-related kidney diseases as well as discuss the application of epigenetic modifiers as potential biomarkers and therapeutic targets in the field of age-related kidney diseases. In summary, the main types of epigenetic processes including DNA methylation, histone modifications, non-coding RNA (ncRNA) modulation have all been implicated in the progression of age-related kidney diseases, and therapeutic targeting of these processes will yield novel therapeutic strategies for the prevention and/or treatment of age-related kidney diseases. MDPI 2022-04-29 /pmc/articles/PMC9142069/ /pubmed/35627181 http://dx.doi.org/10.3390/genes13050796 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Liu, Feng
Chen, Jiefang
Li, Zhenqiong
Meng, Xianfang
Recent Advances in Epigenetics of Age-Related Kidney Diseases
title Recent Advances in Epigenetics of Age-Related Kidney Diseases
title_full Recent Advances in Epigenetics of Age-Related Kidney Diseases
title_fullStr Recent Advances in Epigenetics of Age-Related Kidney Diseases
title_full_unstemmed Recent Advances in Epigenetics of Age-Related Kidney Diseases
title_short Recent Advances in Epigenetics of Age-Related Kidney Diseases
title_sort recent advances in epigenetics of age-related kidney diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142069/
https://www.ncbi.nlm.nih.gov/pubmed/35627181
http://dx.doi.org/10.3390/genes13050796
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