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Structure of the IL-27 quaternary receptor signaling complex

Interleukin 27 (IL-27) is a heterodimeric cytokine that functions to constrain T cell-mediated inflammation and plays an important role in immune homeostasis. Binding of IL-27 to cell surface receptors, IL-27Rα and gp130, results in activation of receptor-associated Janus Kinases and nuclear translo...

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Detalles Bibliográficos
Autores principales:	Caveney, Nathanael A, Glassman, Caleb R, Jude, Kevin M, Tsutsumi, Naotaka, Garcia, K Christopher
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Immunology and Inflammation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142143/ https://www.ncbi.nlm.nih.gov/pubmed/35579417 http://dx.doi.org/10.7554/eLife.78463

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