Oct4 differentially regulates chromatin opening and enhancer transcription in pluripotent stem cells

The transcription factor Oct4 is essential for the maintenance and induction of stem cell pluripotency, but its functional roles are not fully understood. Here, we investigate the functions of Oct4 by depleting and subsequently recovering it in mouse embryonic stem cells (ESCs) and conducting a time...

Descripción completa

Detalles Bibliográficos
Autores principales: Xiong, Le, Tolen, Erik A, Choi, Jinmi, Velychko, Sergiy, Caizzi, Livia, Velychko, Taras, Adachi, Kenjiro, MacCarthy, Caitlin M, Lidschreiber, Michael, Cramer, Patrick, Schöler, Hans R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142147/
https://www.ncbi.nlm.nih.gov/pubmed/35621159
http://dx.doi.org/10.7554/eLife.71533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142147/
https://www.ncbi.nlm.nih.gov/pubmed/35621159
http://dx.doi.org/10.7554/eLife.71533

Ejemplares similares