A B-cell actomyosin arc network couples integrin co-stimulation to mechanical force-dependent immune synapse formation

B-cell activation and immune synapse (IS) formation with membrane-bound antigens are actin-dependent processes that scale positively with the strength of antigen-induced signals. Importantly, ligating the B-cell integrin, LFA-1, with ICAM-1 promotes IS formation when antigen is limiting. Whether the...

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Detalles Bibliográficos
Autores principales: Wang, Jia C, Yim, Yang-In, Wu, Xufeng, Jaumouille, Valentin, Cameron, Andrew, Waterman, Clare M, Kehrl, John H, Hammer, John A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142150/
https://www.ncbi.nlm.nih.gov/pubmed/35404237
http://dx.doi.org/10.7554/eLife.72805

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