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Mutation Detection and Functional Analysis of MSX1, PAX9, AXIN2, and BMP in Nonsyndromic Congenital Missing Teeth Based on Intelligent Image Detection

Due to the complexity of clinical manifestations and the lack of standardized diagnostic criteria, it is still difficult to distinguish the etiological types of congenital edentulousness corresponding to genetic defects. This paper studies the application of deep learning image processing and digita...

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Autores principales: Yao, Xueqin, Zhang, Cheng, Gao, Peipei, Meng, Zixuan, Hao, Yonghong, Yan, Jingjing, Yao, Wenbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142294/
https://www.ncbi.nlm.nih.gov/pubmed/35647187
http://dx.doi.org/10.1155/2022/6217399
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author Yao, Xueqin
Zhang, Cheng
Gao, Peipei
Meng, Zixuan
Hao, Yonghong
Yan, Jingjing
Yao, Wenbo
author_facet Yao, Xueqin
Zhang, Cheng
Gao, Peipei
Meng, Zixuan
Hao, Yonghong
Yan, Jingjing
Yao, Wenbo
author_sort Yao, Xueqin
collection PubMed
description Due to the complexity of clinical manifestations and the lack of standardized diagnostic criteria, it is still difficult to distinguish the etiological types of congenital edentulousness corresponding to genetic defects. This paper studies the application of deep learning image processing and digital image processing in medical images in detail and analyzes the functions of congenital edentulous hotspot genes. The cases in the control group and the study group were collected, and the gene mutations of direct sequence MSX1, PAX9, AXIN2, and BMP were analyzed, and new pathogens were found. The experimental results suggest that PAX9 and MSX1 genes may have a synergistic effect in nonsyndromic congenital edentulous patients. In severely missing teeth, the role of PAX9 may be greater than that of MSX1. The experimental results will help us lay the foundation for further understanding of the disease in the future.
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spelling pubmed-91422942022-05-28 Mutation Detection and Functional Analysis of MSX1, PAX9, AXIN2, and BMP in Nonsyndromic Congenital Missing Teeth Based on Intelligent Image Detection Yao, Xueqin Zhang, Cheng Gao, Peipei Meng, Zixuan Hao, Yonghong Yan, Jingjing Yao, Wenbo Biomed Res Int Research Article Due to the complexity of clinical manifestations and the lack of standardized diagnostic criteria, it is still difficult to distinguish the etiological types of congenital edentulousness corresponding to genetic defects. This paper studies the application of deep learning image processing and digital image processing in medical images in detail and analyzes the functions of congenital edentulous hotspot genes. The cases in the control group and the study group were collected, and the gene mutations of direct sequence MSX1, PAX9, AXIN2, and BMP were analyzed, and new pathogens were found. The experimental results suggest that PAX9 and MSX1 genes may have a synergistic effect in nonsyndromic congenital edentulous patients. In severely missing teeth, the role of PAX9 may be greater than that of MSX1. The experimental results will help us lay the foundation for further understanding of the disease in the future. Hindawi 2022-05-20 /pmc/articles/PMC9142294/ /pubmed/35647187 http://dx.doi.org/10.1155/2022/6217399 Text en Copyright © 2022 Xueqin Yao et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yao, Xueqin
Zhang, Cheng
Gao, Peipei
Meng, Zixuan
Hao, Yonghong
Yan, Jingjing
Yao, Wenbo
Mutation Detection and Functional Analysis of MSX1, PAX9, AXIN2, and BMP in Nonsyndromic Congenital Missing Teeth Based on Intelligent Image Detection
title Mutation Detection and Functional Analysis of MSX1, PAX9, AXIN2, and BMP in Nonsyndromic Congenital Missing Teeth Based on Intelligent Image Detection
title_full Mutation Detection and Functional Analysis of MSX1, PAX9, AXIN2, and BMP in Nonsyndromic Congenital Missing Teeth Based on Intelligent Image Detection
title_fullStr Mutation Detection and Functional Analysis of MSX1, PAX9, AXIN2, and BMP in Nonsyndromic Congenital Missing Teeth Based on Intelligent Image Detection
title_full_unstemmed Mutation Detection and Functional Analysis of MSX1, PAX9, AXIN2, and BMP in Nonsyndromic Congenital Missing Teeth Based on Intelligent Image Detection
title_short Mutation Detection and Functional Analysis of MSX1, PAX9, AXIN2, and BMP in Nonsyndromic Congenital Missing Teeth Based on Intelligent Image Detection
title_sort mutation detection and functional analysis of msx1, pax9, axin2, and bmp in nonsyndromic congenital missing teeth based on intelligent image detection
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142294/
https://www.ncbi.nlm.nih.gov/pubmed/35647187
http://dx.doi.org/10.1155/2022/6217399
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