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Mutation Detection and Functional Analysis of MSX1, PAX9, AXIN2, and BMP in Nonsyndromic Congenital Missing Teeth Based on Intelligent Image Detection
Due to the complexity of clinical manifestations and the lack of standardized diagnostic criteria, it is still difficult to distinguish the etiological types of congenital edentulousness corresponding to genetic defects. This paper studies the application of deep learning image processing and digita...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142294/ https://www.ncbi.nlm.nih.gov/pubmed/35647187 http://dx.doi.org/10.1155/2022/6217399 |
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author | Yao, Xueqin Zhang, Cheng Gao, Peipei Meng, Zixuan Hao, Yonghong Yan, Jingjing Yao, Wenbo |
author_facet | Yao, Xueqin Zhang, Cheng Gao, Peipei Meng, Zixuan Hao, Yonghong Yan, Jingjing Yao, Wenbo |
author_sort | Yao, Xueqin |
collection | PubMed |
description | Due to the complexity of clinical manifestations and the lack of standardized diagnostic criteria, it is still difficult to distinguish the etiological types of congenital edentulousness corresponding to genetic defects. This paper studies the application of deep learning image processing and digital image processing in medical images in detail and analyzes the functions of congenital edentulous hotspot genes. The cases in the control group and the study group were collected, and the gene mutations of direct sequence MSX1, PAX9, AXIN2, and BMP were analyzed, and new pathogens were found. The experimental results suggest that PAX9 and MSX1 genes may have a synergistic effect in nonsyndromic congenital edentulous patients. In severely missing teeth, the role of PAX9 may be greater than that of MSX1. The experimental results will help us lay the foundation for further understanding of the disease in the future. |
format | Online Article Text |
id | pubmed-9142294 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-91422942022-05-28 Mutation Detection and Functional Analysis of MSX1, PAX9, AXIN2, and BMP in Nonsyndromic Congenital Missing Teeth Based on Intelligent Image Detection Yao, Xueqin Zhang, Cheng Gao, Peipei Meng, Zixuan Hao, Yonghong Yan, Jingjing Yao, Wenbo Biomed Res Int Research Article Due to the complexity of clinical manifestations and the lack of standardized diagnostic criteria, it is still difficult to distinguish the etiological types of congenital edentulousness corresponding to genetic defects. This paper studies the application of deep learning image processing and digital image processing in medical images in detail and analyzes the functions of congenital edentulous hotspot genes. The cases in the control group and the study group were collected, and the gene mutations of direct sequence MSX1, PAX9, AXIN2, and BMP were analyzed, and new pathogens were found. The experimental results suggest that PAX9 and MSX1 genes may have a synergistic effect in nonsyndromic congenital edentulous patients. In severely missing teeth, the role of PAX9 may be greater than that of MSX1. The experimental results will help us lay the foundation for further understanding of the disease in the future. Hindawi 2022-05-20 /pmc/articles/PMC9142294/ /pubmed/35647187 http://dx.doi.org/10.1155/2022/6217399 Text en Copyright © 2022 Xueqin Yao et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Yao, Xueqin Zhang, Cheng Gao, Peipei Meng, Zixuan Hao, Yonghong Yan, Jingjing Yao, Wenbo Mutation Detection and Functional Analysis of MSX1, PAX9, AXIN2, and BMP in Nonsyndromic Congenital Missing Teeth Based on Intelligent Image Detection |
title | Mutation Detection and Functional Analysis of MSX1, PAX9, AXIN2, and BMP in Nonsyndromic Congenital Missing Teeth Based on Intelligent Image Detection |
title_full | Mutation Detection and Functional Analysis of MSX1, PAX9, AXIN2, and BMP in Nonsyndromic Congenital Missing Teeth Based on Intelligent Image Detection |
title_fullStr | Mutation Detection and Functional Analysis of MSX1, PAX9, AXIN2, and BMP in Nonsyndromic Congenital Missing Teeth Based on Intelligent Image Detection |
title_full_unstemmed | Mutation Detection and Functional Analysis of MSX1, PAX9, AXIN2, and BMP in Nonsyndromic Congenital Missing Teeth Based on Intelligent Image Detection |
title_short | Mutation Detection and Functional Analysis of MSX1, PAX9, AXIN2, and BMP in Nonsyndromic Congenital Missing Teeth Based on Intelligent Image Detection |
title_sort | mutation detection and functional analysis of msx1, pax9, axin2, and bmp in nonsyndromic congenital missing teeth based on intelligent image detection |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142294/ https://www.ncbi.nlm.nih.gov/pubmed/35647187 http://dx.doi.org/10.1155/2022/6217399 |
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