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AURKA and PLK1 inhibition selectively and synergistically block cell cycle progression in diffuse midline glioma
Diffuse midline gliomas (DMG) are highly malignant incurable pediatric brain tumors. In this study, we show that Aurora kinase A (AURKA) is overexpressed in DMG and can be used as a therapeutic target. Additionally, AURKA inhibition combined with CRISPR/Cas9 screening in DMG cells, revealed polo-lik...
Autores principales: | Metselaar, Dennis S., du Chatinier, Aimée, Meel, Michaël H., ter Huizen, Giovanna, Waranecki, Piotr, Goulding, Joshua R., Bugiani, Marianna, Koster, Jan, Kaspers, Gertjan J.L., Hulleman, Esther |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142558/ https://www.ncbi.nlm.nih.gov/pubmed/35637734 http://dx.doi.org/10.1016/j.isci.2022.104398 |
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