Cargando…

AURKA and PLK1 inhibition selectively and synergistically block cell cycle progression in diffuse midline glioma

Diffuse midline gliomas (DMG) are highly malignant incurable pediatric brain tumors. In this study, we show that Aurora kinase A (AURKA) is overexpressed in DMG and can be used as a therapeutic target. Additionally, AURKA inhibition combined with CRISPR/Cas9 screening in DMG cells, revealed polo-lik...

Descripción completa

Detalles Bibliográficos
Autores principales:	Metselaar, Dennis S., du Chatinier, Aimée, Meel, Michaël H., ter Huizen, Giovanna, Waranecki, Piotr, Goulding, Joshua R., Bugiani, Marianna, Koster, Jan, Kaspers, Gertjan J.L., Hulleman, Esther
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142558/ https://www.ncbi.nlm.nih.gov/pubmed/35637734 http://dx.doi.org/10.1016/j.isci.2022.104398

Ejemplares similares

RONC-21. IDENTIFICATION OF EPIGENETIC DRUGS AS RADIOSENSITIZERS IN PEDIATRIC HIGH-GRADE GLIOMAS
por: Metselaar, Dennis, et al.
Publicado: (2020)

An efficient method for the transduction of primary pediatric glioma neurospheres
por: Meel, Michaël H., et al.
Publicado: (2018)

Celastrol-induced degradation of FANCD2 sensitizes pediatric high-grade gliomas to the DNA-crosslinking agent carboplatin
por: Metselaar, Dennis S., et al.
Publicado: (2019)

Generation of immunocompetent syngeneic allograft mouse models for pediatric diffuse midline glioma
por: du Chatinier, Aimée, et al.
Publicado: (2022)

Radiosensitization in Pediatric High-Grade Glioma: Targets, Resistance and Developments
por: Metselaar, Dennis S., et al.
Publicado: (2021)

ATRT-18. SHH-SUBTYPE ATYPICAL TERATOID/RHABDOID TUMORS ARE SELECTIVELY SENSITIVE TO GEMCITABINE TREATMENT
por: Metselaar, Dennis, et al.
Publicado: (2020)

Defining tumor-associated vascular heterogeneity in pediatric high-grade and diffuse midline gliomas
por: Wei, Xin, et al.
Publicado: (2021)

Signaling pathways and mesenchymal transition in pediatric high-grade glioma
por: Meel, Michaël H., et al.
Publicado: (2017)

Microglia in pediatric brain tumors: The missing link to successful immunotherapy
por: du Chatinier, Aimée, et al.
Publicado: (2023)

MEK/MELK inhibition and blood–brain barrier deficiencies in atypical teratoid/rhabdoid tumors
por: Meel, Michaël H, et al.
Publicado: (2020)

Deceptive morphologic and epigenetic heterogeneity in diffuse intrinsic pontine glioma
por: Bugiani, Marianna, et al.
Publicado: (2017)

Cross-Talk between AURKA and Plk1 in Mitotic Entry and Spindle Assembly
por: Asteriti, Italia Anna, et al.
Publicado: (2015)

Trimethylation of H3K27 during human cerebellar development in relation to medulloblastoma
por: Mir, Shahryar E., et al.
Publicado: (2017)

DIPG-33. CHARACTERIZING THE NEURO-VASCULAR UNIT IN DIFFUSE INTRINSIC PONTINE GLIOMA
por: El-Khouly, Fatma E, et al.
Publicado: (2020)

A screening-based approach identifies cell cycle regulators AURKA, CHK1 and PLK1 as targetable regulators of chondrosarcoma cell survival
por: de Jong, Yvonne, et al.
Publicado: (2019)

Expression of the Microtubule-Associated Protein MAP9/ASAP and Its Partners AURKA and PLK1 in Colorectal and Breast Cancers
por: Rouquier, Sylvie, et al.
Publicado: (2014)

ZNF655 Promotes the Progression of Glioma Through Transcriptional Regulation of AURKA
por: Chen, Xu, et al.
Publicado: (2022)

Tanshinone IIA suppresses the progression of lung adenocarcinoma through regulating CCNA2-CDK2 complex and AURKA/PLK1 pathway
por: Li, Ziheng, et al.
Publicado: (2021)

PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation
por: van Vuurden, Dannis G., et al.
Publicado: (2011)

Pre-Clinical Evaluation of the Proteasome Inhibitor Ixazomib against Bortezomib-Resistant Leukemia Cells and Primary Acute Leukemia Cells
por: Roeten, Margot S.F., et al.
Publicado: (2021)

Retraction: ZNF655 promotes the progression of glioma through transcriptional regulation of AURKA
Publicado: (2023)

Dual BRD4 and AURKA Inhibition Is Synergistic against MYCN-Amplified and Nonamplified Neuroblastoma()
por: Felgenhauer, Joshua, et al.
Publicado: (2018)

Silencing of AURKA augments the antitumor efficacy of the AURKA inhibitor MLN8237 on neuroblastoma cells
por: Yang, Yan, et al.
Publicado: (2020)

Effective Drug Delivery in Diffuse Intrinsic Pontine Glioma: A Theoretical Model to Identify Potential Candidates
por: El-Khouly, Fatma E., et al.
Publicado: (2017)

AURKA inhibition mimics BRCAness
por: Hirst, Jeff, et al.
Publicado: (2017)

In Vitro Drug Response and Efflux Transporters Associated with Drug Resistance in Pediatric High Grade Glioma and Diffuse Intrinsic Pontine Glioma
por: Veringa, Susanna J. E., et al.
Publicado: (2013)

Pediatric Diffuse Midline Gliomas: An Unfinished Puzzle
por: Di Ruscio, Valentina, et al.
Publicado: (2022)

Immunotherapy approaches for the treatment of diffuse midline gliomas
por: Bernstock, Joshua D., et al.
Publicado: (2022)

Interdisciplinary care of children with diffuse midline glioma
por: Coleman, Christina, et al.
Publicado: (2022)

The promise of metabolic imaging in diffuse midline glioma
por: Lovibond, Samantha, et al.
Publicado: (2023)

CNSC-01. GABAERGIC NEURON-TO-GLIOMA SYNAPSES IN DIFFUSE MIDLINE GLIOMAS
por: Barron, Tara, et al.
Publicado: (2023)

Overview of Current Drug Delivery Methods Across the Blood–Brain Barrier for the Treatment of Primary Brain Tumors
por: Haumann, Rianne, et al.
Publicado: (2020)

Integrated pan‐cancer of AURKA expression and drug sensitivity analysis reveals increased expression of AURKA is responsible for drug resistance
por: Miralaei, Noushin, et al.
Publicado: (2021)

Midline Glioma in Adults: Clinicopathological, Genetic, and Epigenetic Analysis
por: ENOMOTO, Toshiyuki, et al.
Publicado: (2020)

Clinical and Genomic Characteristics of Adult Diffuse Midline Glioma
por: Park, Changhee, et al.
Publicado: (2021)

Therapeutic Targets in Diffuse Midline Gliomas—An Emerging Landscape
por: Hayden, Elisha, et al.
Publicado: (2021)

DIPG-44. DIFFUSE MIDLINE GLIOMA WITH EXTRACRANIAL METASTASIS
por: Larsen, Alexandra Giantini, et al.
Publicado: (2023)

Potent antitumor efficacy of anti-GD2 CAR T-cells in H3K27M+ diffuse midline gliomas
por: Mount, Christopher W., et al.
Publicado: (2018)

MRI comparative study of diffuse midline glioma, H3 K27-altered and glioma in the midline without H3 K27-altered
por: Zhao, Ji-ping, et al.
Publicado: (2022)

Radio-Resistance and DNA Repair in Pediatric Diffuse Midline Gliomas
por: Pedersen, Henriette, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ufc6c2eq0hf4u7se55quqniqad