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AURKA and PLK1 inhibition selectively and synergistically block cell cycle progression in diffuse midline glioma

Diffuse midline gliomas (DMG) are highly malignant incurable pediatric brain tumors. In this study, we show that Aurora kinase A (AURKA) is overexpressed in DMG and can be used as a therapeutic target. Additionally, AURKA inhibition combined with CRISPR/Cas9 screening in DMG cells, revealed polo-lik...

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Detalles Bibliográficos
Autores principales:	Metselaar, Dennis S., du Chatinier, Aimée, Meel, Michaël H., ter Huizen, Giovanna, Waranecki, Piotr, Goulding, Joshua R., Bugiani, Marianna, Koster, Jan, Kaspers, Gertjan J.L., Hulleman, Esther
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142558/ https://www.ncbi.nlm.nih.gov/pubmed/35637734 http://dx.doi.org/10.1016/j.isci.2022.104398

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