Cargando…

PBX1, EMCN and ERG are associated with the sub-clusters and the prognosis of VHL mutant clear cell renal cell carcinoma

The molecular heterogeneity of primary clear cell renal cell carcinoma (ccRCC) has been reported. However, the classifications of Von Hippel–Lindau (VHL) mutant ccRCC are unclear. Here, VHL mutant ccRCC from The Cancer Genome Atlas and E-MTAB-1980 datasets were divided into two sub-clusters through...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Haiwei, Wang, Xinrui, Xu, Liangpu, Zhang, Ji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142578/ https://www.ncbi.nlm.nih.gov/pubmed/35624190 http://dx.doi.org/10.1038/s41598-022-13148-7

Ejemplares similares

A molecular sub-cluster of colon cancer cells with low VDR expression is sensitive to chemotherapy, BRAF inhibitors and PI3K-mTOR inhibitors treatment
por: Wang, Haiwei, et al.
Publicado: (2019)

Chromosome 1p36 candidate gene ZNF436 predicts the prognosis of neuroblastoma: a bioinformatic analysis
por: Wang, Haiwei, et al.
Publicado: (2023)

TP53 and TP53-associated genes are correlated with the prognosis of paediatric neuroblastoma
por: Wang, Haiwei, et al.
Publicado: (2022)

Tumor heterogeneity in VHL drives metastasis in clear cell renal cell carcinoma
por: Hu, Junhui, et al.
Publicado: (2023)

Multi-Omics Profiling to Assess Signaling Changes upon VHL Restoration and Identify Putative VHL Substrates in Clear Cell Renal Cell Carcinoma Cell Lines
por: Wang, Xuechun, et al.
Publicado: (2022)

Nonnegative matrix factorization‐based bioinformatics analysis reveals that TPX2 and SELENBP1 are two predictors of the inner sub‐consensuses of lung adenocarcinoma
por: Wang, Haiwei, et al.
Publicado: (2021)

RUNX1 and REXO2 are associated with the heterogeneity and prognosis of IDH wild type lower grade glioma
por: Wang, Haiwei, et al.
Publicado: (2021)

Von Hippel-Lindau (VHL) Inactivation in Sporadic Clear Cell Renal Cancer: Associations with Germline VHL Polymorphisms and Etiologic Risk Factors
por: Moore, Lee E., et al.
Publicado: (2011)

A pan-cancer perspective analysis reveals the opposite prognostic significance of CD133 in lower grade glioma and papillary renal cell carcinoma
por: Wang, Haiwei, et al.
Publicado: (2021)

Loss of endothelial EMCN drives tumor lung metastasis through the premetastatic niche
por: Zhang, Guoxin, et al.
Publicado: (2022)

Dynamic epigenetic changes to VHL occur with sunitinib in metastatic clear cell renal cancer
por: Stewart, Grant D., et al.
Publicado: (2016)

Cytosine 5-hydroxymethylation regulates VHL gene expression in renal clear cell carcinoma
por: Ma, En-Guang, et al.
Publicado: (2017)

VHL suppresses RAPTOR and inhibits mTORC1 signaling in clear cell renal cell carcinoma
por: Ganner, Athina, et al.
Publicado: (2021)

TP53 inhibitor PFTα increases the sensitivity of arsenic trioxide in TP53 wildtype tumor cells
por: Wang, Haiwei, et al.
Publicado: (2022)

Characterization of VHL missense mutations in sporadic clear cell renal cell carcinoma: hotspots, affected binding domains, functional impact on pVHL and therapeutic relevance
por: Razafinjatovo, Caroline, et al.
Publicado: (2016)

Determination of the consequences of VHL mutations on VHL transcripts in renal cell carcinoma
por: TAYLOR, CLAIRE, et al.
Publicado: (2012)

Targeting HIF2α Translation with Tempol in VHL-Deficient Clear Cell Renal Cell Carcinoma
por: Sourbier, Carole, et al.
Publicado: (2012)

Loss of vhl in the zebrafish pronephros recapitulates early stages of human clear cell renal cell carcinoma
por: Noonan, Haley R., et al.
Publicado: (2016)

VHL Dependent Expression of REDD1 and PDK3 Proteins in Clear-cell Renal Cell Carcinoma
por: Ilic, Bojana B, et al.
Publicado: (2018)

Identification and validation of the clinical roles of the VHL-related LncRNAs in clear cell renal cell carcinoma
por: Yang, Wuping, et al.
Publicado: (2021)

Development and validation of a VHL-associated immune prognostic signature for clear cell renal cell carcinoma
por: Zhang, Jin, et al.
Publicado: (2020)

VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2
por: Gao, Yao-Hui, et al.
Publicado: (2017)

The Clinical and Molecular Features in the VHL Renal Cancers; Close or Distant Relatives with Sporadic Clear Cell Renal Cell Carcinoma?
por: Cinque, Alessandra, et al.
Publicado: (2022)

Deubiquitylase OTUD6B stabilizes the mutated pVHL and suppresses cell migration in clear cell renal cell carcinoma
por: Guo, Kai, et al.
Publicado: (2022)

Clinicopathologic Significance of VHL Gene Alteration in Clear-Cell Renal Cell Carcinoma: An Updated Meta-Analysis and Review
por: Kim, Hyeong Su, et al.
Publicado: (2018)

Combined Vhl, Trp53 and Rb1 mutation causes clear cell renal cell carcinoma in mice
por: Harlander, Sabine, et al.
Publicado: (2017)

Identification of PBX1 Target Genes in Cancer Cells by Global Mapping of PBX1 Binding Sites
por: Thiaville, Michelle M., et al.
Publicado: (2012)

CpG methylation profiling in VHL related and VHL unrelated renal cell carcinoma
por: McRonald, Fiona E, et al.
Publicado: (2009)

Correction to: Deubiquitylase OTUD6B stabilizes the mutated pVHL and suppresses cell migration in clear cell renal cell carcinoma
por: Guo, Kai, et al.
Publicado: (2022)

Aucubin Impeded Preosteoclast Fusion and Enhanced CD31(hi) EMCN(hi) Vessel Angiogenesis in Ovariectomized Mice
por: Li, Ziyi, et al.
Publicado: (2022)

Kidney in VHL disease: Early clear cell proliferation occurs in the distal tubular system
por: Al-Gharaibeh, Nayef S., et al.
Publicado: (2022)

Identification of pVHL as a Novel Substrate for Aurora-A in Clear Cell Renal Cell Carcinoma (ccRCC)
por: Martin, Benedicte, et al.
Publicado: (2013)

Dicer suppresses the malignant phenotype in VHL-deficient clear cell renal cell carcinoma by inhibiting HIF-2α
por: Fan, Yang, et al.
Publicado: (2016)

MYC activation cooperates with Vhl and Ink4a/Arf loss to induce clear cell renal cell carcinoma
por: Bailey, Sean T., et al.
Publicado: (2017)

VHL L169P Variant Does Not Alter Cellular Hypoxia Tension in Clear Cell Renal Cell Carcinoma
por: Hu, Junhui, et al.
Publicado: (2023)

Identification of transcription factors MYC and C/EBPβ mediated regulatory networks in heart failure based on gene expression omnibus datasets
por: Wang, Haiwei, et al.
Publicado: (2020)

Prognostic analysis of E2F transcription factors E2F1 and E2F3 in four independent pediatric neuroblastoma cohorts
por: Wang, Haiwei, et al.
Publicado: (2022)

Co‐amplified with PDGFRA, IGFBP7 is a prognostic biomarker correlated with the immune infiltrations of glioma
por: Wang, Haiwei, et al.
Publicado: (2022)

Ophiopogonin D promotes bone regeneration by stimulating CD31(hi)EMCN(hi) vessel formation
por: Yang, Mi, et al.
Publicado: (2020)

An integrated computational approach can classify VHL missense mutations according to risk of clear cell renal carcinoma
por: Gossage, Lucy, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_rugqpl3bpgr32amdiov57mgjm2