Sorafenib and nitazoxanide disrupt mitochondrial function and inhibit regrowth capacity in three-dimensional models of hepatocellular and colorectal carcinoma

Quiescent cancer cells in malignant tumors can withstand cell-cycle active treatment and cause cancer spread and recurrence. Three-dimensional (3D) cancer cell models have led to the identification of oxidative phosphorylation (OXPHOS) as a context-dependent vulnerability. The limited treatment opti...

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Detalles Bibliográficos
Autores principales: Ek, Frida, Blom, Kristin, Selvin, Tove, Rudfeldt, Jakob, Andersson, Claes, Senkowski, Wojciech, Brechot, Christian, Nygren, Peter, Larsson, Rolf, Jarvius, Malin, Fryknäs, Mårten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142582/
https://www.ncbi.nlm.nih.gov/pubmed/35624293
http://dx.doi.org/10.1038/s41598-022-12519-4

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