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Candida glabrata infection of a pancreatic pseudocyst in a COVID-19 patient: A case report and review of the literature

INTRODUCTION: Pancreatic pseudocysts remain a feared complication of acute or chronic pancreatitis and are often characterized by collections of fluids due to underlying damage to the pancreatic ducts, culminating in a walled-off region bereft of an epithelial layer but surrounded by granulation tis...

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Autores principales: Khan, Mohammad Aasim, Almas, Talal, Ullah, Muneeb, Alkhattab, Maha, Shaikh, Fathema, Shaikh, Sufyan, Bagwe, Isha, Antony, Meetty, Khedro, Tarek, Nagarajan, Vikneswaran Raj, Ramjohn, Joshua, Alsufyani, Reema, Almubarak, Dana, Al-Awaid, Abdulla Hussain, Alsufyani, Majid, Nagarajan, Dhineswaran Raj, Khan, Muhammad Omer, Huang, Helen, Oruk, Mert, Samy, Arjun, Alqallaf, Nagi, Shafi, Adil, Adeel, Aqsa, Khan, Muhammad Kashif
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142617/
https://www.ncbi.nlm.nih.gov/pubmed/35638027
http://dx.doi.org/10.1016/j.amsu.2022.103648
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author Khan, Mohammad Aasim
Almas, Talal
Ullah, Muneeb
Alkhattab, Maha
Shaikh, Fathema
Shaikh, Sufyan
Bagwe, Isha
Antony, Meetty
Khedro, Tarek
Nagarajan, Vikneswaran Raj
Ramjohn, Joshua
Alsufyani, Reema
Almubarak, Dana
Al-Awaid, Abdulla Hussain
Alsufyani, Majid
Nagarajan, Dhineswaran Raj
Khan, Muhammad Omer
Huang, Helen
Oruk, Mert
Samy, Arjun
Alqallaf, Nagi
Shafi, Adil
Adeel, Aqsa
Khan, Muhammad Kashif
author_facet Khan, Mohammad Aasim
Almas, Talal
Ullah, Muneeb
Alkhattab, Maha
Shaikh, Fathema
Shaikh, Sufyan
Bagwe, Isha
Antony, Meetty
Khedro, Tarek
Nagarajan, Vikneswaran Raj
Ramjohn, Joshua
Alsufyani, Reema
Almubarak, Dana
Al-Awaid, Abdulla Hussain
Alsufyani, Majid
Nagarajan, Dhineswaran Raj
Khan, Muhammad Omer
Huang, Helen
Oruk, Mert
Samy, Arjun
Alqallaf, Nagi
Shafi, Adil
Adeel, Aqsa
Khan, Muhammad Kashif
author_sort Khan, Mohammad Aasim
collection PubMed
description INTRODUCTION: Pancreatic pseudocysts remain a feared complication of acute or chronic pancreatitis and are often characterized by collections of fluids due to underlying damage to the pancreatic ducts, culminating in a walled-off region bereft of an epithelial layer but surrounded by granulation tissue. While fungal infections of pancreatic pseudocysts are rarely encountered, candida albicans remains the most frequently implicated organism. CASE PRESENTATION: A 55-year-old male presented with pain in the left-hypochondriac region, accompanied by non-bilious emesis and nausea. Interestingly, the patient also tested positive for a COVID-19 infection. Investigative workup divulged enhancing pancreatic walls with a radiologic impression consistent with a pancreatic pseudocyst. An ultrasound-guided external drainage was performed; the drainage was conducted unremarkably, with the resultant fluid collection revealing the presence of Candida Glabrata. The patient was commenced on antifungal therapy and continues to do well to date. DISCUSSION: Infectious ailments of pancreatic pseudocysts remain a widely known complication of acute pancreatitis. While it is rare, fungal infection is a crucial consideration for patients with pancreatic pseudocysts, especially in the context of a lack of an adequate response to antibiotics, deterioration, comorbidities, and immunocompromised states. CONCLUSION: Rapid identification of the microbe responsible for pancreatic pseudocyst infection is vital for time-sensitive treatment and a more rapid recovery, curbing associated morbidity and mortality.
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spelling pubmed-91426172022-05-29 Candida glabrata infection of a pancreatic pseudocyst in a COVID-19 patient: A case report and review of the literature Khan, Mohammad Aasim Almas, Talal Ullah, Muneeb Alkhattab, Maha Shaikh, Fathema Shaikh, Sufyan Bagwe, Isha Antony, Meetty Khedro, Tarek Nagarajan, Vikneswaran Raj Ramjohn, Joshua Alsufyani, Reema Almubarak, Dana Al-Awaid, Abdulla Hussain Alsufyani, Majid Nagarajan, Dhineswaran Raj Khan, Muhammad Omer Huang, Helen Oruk, Mert Samy, Arjun Alqallaf, Nagi Shafi, Adil Adeel, Aqsa Khan, Muhammad Kashif Ann Med Surg (Lond) Case Report INTRODUCTION: Pancreatic pseudocysts remain a feared complication of acute or chronic pancreatitis and are often characterized by collections of fluids due to underlying damage to the pancreatic ducts, culminating in a walled-off region bereft of an epithelial layer but surrounded by granulation tissue. While fungal infections of pancreatic pseudocysts are rarely encountered, candida albicans remains the most frequently implicated organism. CASE PRESENTATION: A 55-year-old male presented with pain in the left-hypochondriac region, accompanied by non-bilious emesis and nausea. Interestingly, the patient also tested positive for a COVID-19 infection. Investigative workup divulged enhancing pancreatic walls with a radiologic impression consistent with a pancreatic pseudocyst. An ultrasound-guided external drainage was performed; the drainage was conducted unremarkably, with the resultant fluid collection revealing the presence of Candida Glabrata. The patient was commenced on antifungal therapy and continues to do well to date. DISCUSSION: Infectious ailments of pancreatic pseudocysts remain a widely known complication of acute pancreatitis. While it is rare, fungal infection is a crucial consideration for patients with pancreatic pseudocysts, especially in the context of a lack of an adequate response to antibiotics, deterioration, comorbidities, and immunocompromised states. CONCLUSION: Rapid identification of the microbe responsible for pancreatic pseudocyst infection is vital for time-sensitive treatment and a more rapid recovery, curbing associated morbidity and mortality. Elsevier 2022-04-19 /pmc/articles/PMC9142617/ /pubmed/35638027 http://dx.doi.org/10.1016/j.amsu.2022.103648 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Khan, Mohammad Aasim
Almas, Talal
Ullah, Muneeb
Alkhattab, Maha
Shaikh, Fathema
Shaikh, Sufyan
Bagwe, Isha
Antony, Meetty
Khedro, Tarek
Nagarajan, Vikneswaran Raj
Ramjohn, Joshua
Alsufyani, Reema
Almubarak, Dana
Al-Awaid, Abdulla Hussain
Alsufyani, Majid
Nagarajan, Dhineswaran Raj
Khan, Muhammad Omer
Huang, Helen
Oruk, Mert
Samy, Arjun
Alqallaf, Nagi
Shafi, Adil
Adeel, Aqsa
Khan, Muhammad Kashif
Candida glabrata infection of a pancreatic pseudocyst in a COVID-19 patient: A case report and review of the literature
title Candida glabrata infection of a pancreatic pseudocyst in a COVID-19 patient: A case report and review of the literature
title_full Candida glabrata infection of a pancreatic pseudocyst in a COVID-19 patient: A case report and review of the literature
title_fullStr Candida glabrata infection of a pancreatic pseudocyst in a COVID-19 patient: A case report and review of the literature
title_full_unstemmed Candida glabrata infection of a pancreatic pseudocyst in a COVID-19 patient: A case report and review of the literature
title_short Candida glabrata infection of a pancreatic pseudocyst in a COVID-19 patient: A case report and review of the literature
title_sort candida glabrata infection of a pancreatic pseudocyst in a covid-19 patient: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142617/
https://www.ncbi.nlm.nih.gov/pubmed/35638027
http://dx.doi.org/10.1016/j.amsu.2022.103648
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