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Late onset Wilson Disease with normal neuro-psychiatric status: A case report

INTRODUCTION: Late onset Wilson disease (WD) is a rare form of WD. WD has variability of clinical presentations from acute liver failure to chronic liver disease (CLD). The hepatic and neurological variants of WD have wider variations. CASE PRESENTATION: A 55-year-old female, known case of CLD, pres...

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Autores principales: Dhakal, Bishal, Prabhat, K.C., Karki, Abinash, Bhattarai, Ayush Mohan, Sapkota, Sachin, Subedi, Binaya, Dahal, Abhinav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142667/
https://www.ncbi.nlm.nih.gov/pubmed/35638048
http://dx.doi.org/10.1016/j.amsu.2022.103678
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author Dhakal, Bishal
Prabhat, K.C.
Karki, Abinash
Bhattarai, Ayush Mohan
Sapkota, Sachin
Subedi, Binaya
Dahal, Abhinav
author_facet Dhakal, Bishal
Prabhat, K.C.
Karki, Abinash
Bhattarai, Ayush Mohan
Sapkota, Sachin
Subedi, Binaya
Dahal, Abhinav
author_sort Dhakal, Bishal
collection PubMed
description INTRODUCTION: Late onset Wilson disease (WD) is a rare form of WD. WD has variability of clinical presentations from acute liver failure to chronic liver disease (CLD). The hepatic and neurological variants of WD have wider variations. CASE PRESENTATION: A 55-year-old female, known case of CLD, presenting with generalized body swelling and abdominal pain, was diagnosed with late onset WD with normal neuro-psychiatric status. She was treated with zinc and considered for liver transplantation. CLINICAL DISCUSSION: Late onset WD is itself a rare form of WD. Within it, neurological manifestations are common in late onset WD, which was quite opposite as compared to our case. Similarly, diagnostic delay has been a concern in late onset WD with CLD as with our case. CONCLUSIONS: In spite of being uncommon in later age, WD and its different variations like with normal neuro-psychiatric status should be considered as an etiology in cases of unexplained liver diseases.
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spelling pubmed-91426672022-05-29 Late onset Wilson Disease with normal neuro-psychiatric status: A case report Dhakal, Bishal Prabhat, K.C. Karki, Abinash Bhattarai, Ayush Mohan Sapkota, Sachin Subedi, Binaya Dahal, Abhinav Ann Med Surg (Lond) Case Report INTRODUCTION: Late onset Wilson disease (WD) is a rare form of WD. WD has variability of clinical presentations from acute liver failure to chronic liver disease (CLD). The hepatic and neurological variants of WD have wider variations. CASE PRESENTATION: A 55-year-old female, known case of CLD, presenting with generalized body swelling and abdominal pain, was diagnosed with late onset WD with normal neuro-psychiatric status. She was treated with zinc and considered for liver transplantation. CLINICAL DISCUSSION: Late onset WD is itself a rare form of WD. Within it, neurological manifestations are common in late onset WD, which was quite opposite as compared to our case. Similarly, diagnostic delay has been a concern in late onset WD with CLD as with our case. CONCLUSIONS: In spite of being uncommon in later age, WD and its different variations like with normal neuro-psychiatric status should be considered as an etiology in cases of unexplained liver diseases. Elsevier 2022-05-06 /pmc/articles/PMC9142667/ /pubmed/35638048 http://dx.doi.org/10.1016/j.amsu.2022.103678 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Dhakal, Bishal
Prabhat, K.C.
Karki, Abinash
Bhattarai, Ayush Mohan
Sapkota, Sachin
Subedi, Binaya
Dahal, Abhinav
Late onset Wilson Disease with normal neuro-psychiatric status: A case report
title Late onset Wilson Disease with normal neuro-psychiatric status: A case report
title_full Late onset Wilson Disease with normal neuro-psychiatric status: A case report
title_fullStr Late onset Wilson Disease with normal neuro-psychiatric status: A case report
title_full_unstemmed Late onset Wilson Disease with normal neuro-psychiatric status: A case report
title_short Late onset Wilson Disease with normal neuro-psychiatric status: A case report
title_sort late onset wilson disease with normal neuro-psychiatric status: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142667/
https://www.ncbi.nlm.nih.gov/pubmed/35638048
http://dx.doi.org/10.1016/j.amsu.2022.103678
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