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Inhibition of B-cell lymphoma 2 family proteins alters optical redox ratio, mitochondrial polarization, and cell energetics independent of cell state

SIGNIFICANCE: The optical redox ratio (ORR) [autofluorescence intensity of the reduced form of nicotinamide adenine dinucleotide (phosphate) (NAD(P)H)/flavin adenine dinucleotide (FAD)] provides a label-free method to quantify cellular metabolism. However, it is unclear whether changes in the ORR wi...

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Detalles Bibliográficos
Autores principales:	Gillette, Amani A., DeStefanis, Rebecca A., Pritzl, Stephanie L., Deming, Dustin A., Skala, Melissa C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Society of Photo-Optical Instrumentation Engineers 2022
Materias:	Microscopy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142839/ https://www.ncbi.nlm.nih.gov/pubmed/35643815 http://dx.doi.org/10.1117/1.JBO.27.5.056505

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