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Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study
Pulmonary sporotrichosis is a rare condition. It can present as a primary pulmonary disease, resulting from direct Sporothrix species (spp). conidia inhalation, or as part of multifocal sporotrichosis with multiple organ involvement, mainly in immunocompromised patients. This study aimed to describe...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142940/ https://www.ncbi.nlm.nih.gov/pubmed/35628791 http://dx.doi.org/10.3390/jof8050536 |
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author | Fichman, Vivian Mota-Damasceno, Caroline Graça Procópio-Azevedo, Anna Carolina Almeida-Silva, Fernando de Macedo, Priscila Marques Medeiros, Denise Machado Astacio, Guis Saint-Martin Zancopé-Oliveira, Rosely Maria Almeida-Paes, Rodrigo Freitas, Dayvison Francis Saraiva Gutierrez-Galhardo, Maria Clara |
author_facet | Fichman, Vivian Mota-Damasceno, Caroline Graça Procópio-Azevedo, Anna Carolina Almeida-Silva, Fernando de Macedo, Priscila Marques Medeiros, Denise Machado Astacio, Guis Saint-Martin Zancopé-Oliveira, Rosely Maria Almeida-Paes, Rodrigo Freitas, Dayvison Francis Saraiva Gutierrez-Galhardo, Maria Clara |
author_sort | Fichman, Vivian |
collection | PubMed |
description | Pulmonary sporotrichosis is a rare condition. It can present as a primary pulmonary disease, resulting from direct Sporothrix species (spp). conidia inhalation, or as part of multifocal sporotrichosis with multiple organ involvement, mainly in immunocompromised patients. This study aimed to describe the sociodemographic and epidemiological characteristics and clinical course of patients with positive cultures for Sporothrix spp. from pulmonary specimens (sputum and/or bronchoalveolar lavage) at a reference center in an area hyperendemic for zoonotic sporotrichosis. The clinical records of these patients were reviewed. Fourteen patients were included, and Sporothrix brasiliensis was identified in all cases. Disseminated sporotrichosis was the clinical presentation in 92.9% of cases, and primary pulmonary sporotrichosis accounted for 7.1%. Comorbidities included human immunodeficiency virus infection (78.6%), alcoholism (71.4%), and chronic obstructive pulmonary disease (14.3%). Treatment with amphotericin B followed by itraconazole was the preferred regimen and was prescribed in 92.9% of cases. Sporotrichosis-related death occurred in 42.9% while 35.7% of patients were cured. In five cases there was a probable contamination from upper airway lesions. Despite the significant increase in sporotrichosis cases, pulmonary sporotrichosis remains rare. The treatment of disseminated sporotrichosis is typically difficult. Prompt diagnosis and identification of all affected organs are crucial for better prognosis. |
format | Online Article Text |
id | pubmed-9142940 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91429402022-05-29 Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study Fichman, Vivian Mota-Damasceno, Caroline Graça Procópio-Azevedo, Anna Carolina Almeida-Silva, Fernando de Macedo, Priscila Marques Medeiros, Denise Machado Astacio, Guis Saint-Martin Zancopé-Oliveira, Rosely Maria Almeida-Paes, Rodrigo Freitas, Dayvison Francis Saraiva Gutierrez-Galhardo, Maria Clara J Fungi (Basel) Article Pulmonary sporotrichosis is a rare condition. It can present as a primary pulmonary disease, resulting from direct Sporothrix species (spp). conidia inhalation, or as part of multifocal sporotrichosis with multiple organ involvement, mainly in immunocompromised patients. This study aimed to describe the sociodemographic and epidemiological characteristics and clinical course of patients with positive cultures for Sporothrix spp. from pulmonary specimens (sputum and/or bronchoalveolar lavage) at a reference center in an area hyperendemic for zoonotic sporotrichosis. The clinical records of these patients were reviewed. Fourteen patients were included, and Sporothrix brasiliensis was identified in all cases. Disseminated sporotrichosis was the clinical presentation in 92.9% of cases, and primary pulmonary sporotrichosis accounted for 7.1%. Comorbidities included human immunodeficiency virus infection (78.6%), alcoholism (71.4%), and chronic obstructive pulmonary disease (14.3%). Treatment with amphotericin B followed by itraconazole was the preferred regimen and was prescribed in 92.9% of cases. Sporotrichosis-related death occurred in 42.9% while 35.7% of patients were cured. In five cases there was a probable contamination from upper airway lesions. Despite the significant increase in sporotrichosis cases, pulmonary sporotrichosis remains rare. The treatment of disseminated sporotrichosis is typically difficult. Prompt diagnosis and identification of all affected organs are crucial for better prognosis. MDPI 2022-05-21 /pmc/articles/PMC9142940/ /pubmed/35628791 http://dx.doi.org/10.3390/jof8050536 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Fichman, Vivian Mota-Damasceno, Caroline Graça Procópio-Azevedo, Anna Carolina Almeida-Silva, Fernando de Macedo, Priscila Marques Medeiros, Denise Machado Astacio, Guis Saint-Martin Zancopé-Oliveira, Rosely Maria Almeida-Paes, Rodrigo Freitas, Dayvison Francis Saraiva Gutierrez-Galhardo, Maria Clara Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study |
title | Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study |
title_full | Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study |
title_fullStr | Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study |
title_full_unstemmed | Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study |
title_short | Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study |
title_sort | pulmonary sporotrichosis caused by sporothrix brasiliensis: a 22-year, single-center, retrospective cohort study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142940/ https://www.ncbi.nlm.nih.gov/pubmed/35628791 http://dx.doi.org/10.3390/jof8050536 |
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