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Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study

Pulmonary sporotrichosis is a rare condition. It can present as a primary pulmonary disease, resulting from direct Sporothrix species (spp). conidia inhalation, or as part of multifocal sporotrichosis with multiple organ involvement, mainly in immunocompromised patients. This study aimed to describe...

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Autores principales: Fichman, Vivian, Mota-Damasceno, Caroline Graça, Procópio-Azevedo, Anna Carolina, Almeida-Silva, Fernando, de Macedo, Priscila Marques, Medeiros, Denise Machado, Astacio, Guis Saint-Martin, Zancopé-Oliveira, Rosely Maria, Almeida-Paes, Rodrigo, Freitas, Dayvison Francis Saraiva, Gutierrez-Galhardo, Maria Clara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142940/
https://www.ncbi.nlm.nih.gov/pubmed/35628791
http://dx.doi.org/10.3390/jof8050536
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author Fichman, Vivian
Mota-Damasceno, Caroline Graça
Procópio-Azevedo, Anna Carolina
Almeida-Silva, Fernando
de Macedo, Priscila Marques
Medeiros, Denise Machado
Astacio, Guis Saint-Martin
Zancopé-Oliveira, Rosely Maria
Almeida-Paes, Rodrigo
Freitas, Dayvison Francis Saraiva
Gutierrez-Galhardo, Maria Clara
author_facet Fichman, Vivian
Mota-Damasceno, Caroline Graça
Procópio-Azevedo, Anna Carolina
Almeida-Silva, Fernando
de Macedo, Priscila Marques
Medeiros, Denise Machado
Astacio, Guis Saint-Martin
Zancopé-Oliveira, Rosely Maria
Almeida-Paes, Rodrigo
Freitas, Dayvison Francis Saraiva
Gutierrez-Galhardo, Maria Clara
author_sort Fichman, Vivian
collection PubMed
description Pulmonary sporotrichosis is a rare condition. It can present as a primary pulmonary disease, resulting from direct Sporothrix species (spp). conidia inhalation, or as part of multifocal sporotrichosis with multiple organ involvement, mainly in immunocompromised patients. This study aimed to describe the sociodemographic and epidemiological characteristics and clinical course of patients with positive cultures for Sporothrix spp. from pulmonary specimens (sputum and/or bronchoalveolar lavage) at a reference center in an area hyperendemic for zoonotic sporotrichosis. The clinical records of these patients were reviewed. Fourteen patients were included, and Sporothrix brasiliensis was identified in all cases. Disseminated sporotrichosis was the clinical presentation in 92.9% of cases, and primary pulmonary sporotrichosis accounted for 7.1%. Comorbidities included human immunodeficiency virus infection (78.6%), alcoholism (71.4%), and chronic obstructive pulmonary disease (14.3%). Treatment with amphotericin B followed by itraconazole was the preferred regimen and was prescribed in 92.9% of cases. Sporotrichosis-related death occurred in 42.9% while 35.7% of patients were cured. In five cases there was a probable contamination from upper airway lesions. Despite the significant increase in sporotrichosis cases, pulmonary sporotrichosis remains rare. The treatment of disseminated sporotrichosis is typically difficult. Prompt diagnosis and identification of all affected organs are crucial for better prognosis.
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spelling pubmed-91429402022-05-29 Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study Fichman, Vivian Mota-Damasceno, Caroline Graça Procópio-Azevedo, Anna Carolina Almeida-Silva, Fernando de Macedo, Priscila Marques Medeiros, Denise Machado Astacio, Guis Saint-Martin Zancopé-Oliveira, Rosely Maria Almeida-Paes, Rodrigo Freitas, Dayvison Francis Saraiva Gutierrez-Galhardo, Maria Clara J Fungi (Basel) Article Pulmonary sporotrichosis is a rare condition. It can present as a primary pulmonary disease, resulting from direct Sporothrix species (spp). conidia inhalation, or as part of multifocal sporotrichosis with multiple organ involvement, mainly in immunocompromised patients. This study aimed to describe the sociodemographic and epidemiological characteristics and clinical course of patients with positive cultures for Sporothrix spp. from pulmonary specimens (sputum and/or bronchoalveolar lavage) at a reference center in an area hyperendemic for zoonotic sporotrichosis. The clinical records of these patients were reviewed. Fourteen patients were included, and Sporothrix brasiliensis was identified in all cases. Disseminated sporotrichosis was the clinical presentation in 92.9% of cases, and primary pulmonary sporotrichosis accounted for 7.1%. Comorbidities included human immunodeficiency virus infection (78.6%), alcoholism (71.4%), and chronic obstructive pulmonary disease (14.3%). Treatment with amphotericin B followed by itraconazole was the preferred regimen and was prescribed in 92.9% of cases. Sporotrichosis-related death occurred in 42.9% while 35.7% of patients were cured. In five cases there was a probable contamination from upper airway lesions. Despite the significant increase in sporotrichosis cases, pulmonary sporotrichosis remains rare. The treatment of disseminated sporotrichosis is typically difficult. Prompt diagnosis and identification of all affected organs are crucial for better prognosis. MDPI 2022-05-21 /pmc/articles/PMC9142940/ /pubmed/35628791 http://dx.doi.org/10.3390/jof8050536 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fichman, Vivian
Mota-Damasceno, Caroline Graça
Procópio-Azevedo, Anna Carolina
Almeida-Silva, Fernando
de Macedo, Priscila Marques
Medeiros, Denise Machado
Astacio, Guis Saint-Martin
Zancopé-Oliveira, Rosely Maria
Almeida-Paes, Rodrigo
Freitas, Dayvison Francis Saraiva
Gutierrez-Galhardo, Maria Clara
Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study
title Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study
title_full Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study
title_fullStr Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study
title_full_unstemmed Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study
title_short Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study
title_sort pulmonary sporotrichosis caused by sporothrix brasiliensis: a 22-year, single-center, retrospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142940/
https://www.ncbi.nlm.nih.gov/pubmed/35628791
http://dx.doi.org/10.3390/jof8050536
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