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Evaluation of Zn(2+)- and Cu(2+)-Binding Affinities of Native Cu,Zn-SOD1 and Its G93A Mutant by LC-ICP MS

The tight binding of Cu and Zn ions to superoxide dismutase 1 (SOD1) maintains the protein stability, associated with amyotrophic lateral sclerosis (ALS). Yet, the quantitative studies remain to be explored for the metal-binding affinity of wild-type SOD1 and its mutants. We have investigated the de...

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Detalles Bibliográficos
Autores principales:	Smirnova, Julia, Gavrilova, Julia, Noormägi, Andra, Valmsen, Karin, Pupart, Hegne, Luo, Jinghui, Tõugu, Vello, Palumaa, Peep
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142952/ https://www.ncbi.nlm.nih.gov/pubmed/35630637 http://dx.doi.org/10.3390/molecules27103160

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