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Primary and Secondary Progressive Aphasia in Posterior Cortical Atrophy
Background: Posterior cortical atrophy (PCA) is a clinico-radiological syndrome characterized by a progressive decline in visuospatial/visuoperceptual processing. PCA is accompanied by the impairment of other cognitive functions, including language abilities. Methods: The present study focused on th...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142989/ https://www.ncbi.nlm.nih.gov/pubmed/35629330 http://dx.doi.org/10.3390/life12050662 |
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author | Brodeur, Catherine Belley, Émilie Deschênes, Lisa-Marie Enriquez-Rosas, Adriana Hubert, Michelyne Guimond, Anik Bilodeau, Josée Soucy, Jean-Paul Macoir, Joël |
author_facet | Brodeur, Catherine Belley, Émilie Deschênes, Lisa-Marie Enriquez-Rosas, Adriana Hubert, Michelyne Guimond, Anik Bilodeau, Josée Soucy, Jean-Paul Macoir, Joël |
author_sort | Brodeur, Catherine |
collection | PubMed |
description | Background: Posterior cortical atrophy (PCA) is a clinico-radiological syndrome characterized by a progressive decline in visuospatial/visuoperceptual processing. PCA is accompanied by the impairment of other cognitive functions, including language abilities. Methods: The present study focused on three patients presenting with language complaints and a clinical profile that was compatible with PCA. In addition to neurological and neuroimaging examinations, they were assessed with comprehensive batteries of neuropsychological and neurolinguistic tests. Results: The general medical profile of the three patients is consistent with PCA, although they presented with confounding factors, making diagnosis less clear. The cognitive profile of the three patients was marked by Balint and Gerstmann’s syndromes as well as impairments affecting executive functions, short-term and working memory, visuospatial and visuoperceptual abilities, and sensorimotor execution abilities. Their language ability was characterized by word-finding difficulties and impairments of sentence comprehension, sentence repetition, verbal fluency, narrative speech, reading, and writing. Conclusions: This study confirmed that PCA is marked by visuospatial and visuoperceptual deficits and reported evidence of primary and secondary language impairments in the three patients. The similarities of some of their language impairments with those found in the logopenic variant of primary progressive aphasia is discussed from neurolinguistic and neuroanatomical points of view. |
format | Online Article Text |
id | pubmed-9142989 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91429892022-05-29 Primary and Secondary Progressive Aphasia in Posterior Cortical Atrophy Brodeur, Catherine Belley, Émilie Deschênes, Lisa-Marie Enriquez-Rosas, Adriana Hubert, Michelyne Guimond, Anik Bilodeau, Josée Soucy, Jean-Paul Macoir, Joël Life (Basel) Case Report Background: Posterior cortical atrophy (PCA) is a clinico-radiological syndrome characterized by a progressive decline in visuospatial/visuoperceptual processing. PCA is accompanied by the impairment of other cognitive functions, including language abilities. Methods: The present study focused on three patients presenting with language complaints and a clinical profile that was compatible with PCA. In addition to neurological and neuroimaging examinations, they were assessed with comprehensive batteries of neuropsychological and neurolinguistic tests. Results: The general medical profile of the three patients is consistent with PCA, although they presented with confounding factors, making diagnosis less clear. The cognitive profile of the three patients was marked by Balint and Gerstmann’s syndromes as well as impairments affecting executive functions, short-term and working memory, visuospatial and visuoperceptual abilities, and sensorimotor execution abilities. Their language ability was characterized by word-finding difficulties and impairments of sentence comprehension, sentence repetition, verbal fluency, narrative speech, reading, and writing. Conclusions: This study confirmed that PCA is marked by visuospatial and visuoperceptual deficits and reported evidence of primary and secondary language impairments in the three patients. The similarities of some of their language impairments with those found in the logopenic variant of primary progressive aphasia is discussed from neurolinguistic and neuroanatomical points of view. MDPI 2022-04-29 /pmc/articles/PMC9142989/ /pubmed/35629330 http://dx.doi.org/10.3390/life12050662 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Brodeur, Catherine Belley, Émilie Deschênes, Lisa-Marie Enriquez-Rosas, Adriana Hubert, Michelyne Guimond, Anik Bilodeau, Josée Soucy, Jean-Paul Macoir, Joël Primary and Secondary Progressive Aphasia in Posterior Cortical Atrophy |
title | Primary and Secondary Progressive Aphasia in Posterior Cortical Atrophy |
title_full | Primary and Secondary Progressive Aphasia in Posterior Cortical Atrophy |
title_fullStr | Primary and Secondary Progressive Aphasia in Posterior Cortical Atrophy |
title_full_unstemmed | Primary and Secondary Progressive Aphasia in Posterior Cortical Atrophy |
title_short | Primary and Secondary Progressive Aphasia in Posterior Cortical Atrophy |
title_sort | primary and secondary progressive aphasia in posterior cortical atrophy |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142989/ https://www.ncbi.nlm.nih.gov/pubmed/35629330 http://dx.doi.org/10.3390/life12050662 |
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