Atomistic-Level Description of the Covalent Inhibition of SARS-CoV-2 Papain-like Protease

Inhibition of the papain-like protease (PLpro) of SARS-CoV-2 has been demonstrated to be a successful target to prevent the spreading of the coronavirus in the infected body. In this regard, covalent inhibitors, such as the recently proposed VIR251 ligand, can irreversibly inactivate PLpro by formin...

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Detalles Bibliográficos
Autores principales: Hognon, Cécilia, Marazzi, Marco, García-Iriepa, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143025/
https://www.ncbi.nlm.nih.gov/pubmed/35628665
http://dx.doi.org/10.3390/ijms23105855

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