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Seroepidemiology of Toxoplasma gondii Infection in Blood Donors from Western Romania
Background: Toxoplasma gondii is estimated to infect 33% of blood donors worldwide, and seroprevalence varies widely between countries. We aimed to evaluate, for the first time, the seroprevalence and risk factors associated with T. gondii in blood donors from Western Romania. Methods: Serologic tes...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143041/ https://www.ncbi.nlm.nih.gov/pubmed/35630416 http://dx.doi.org/10.3390/microorganisms10050973 |
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author | Lupu, Maria Alina Lighezan, Rodica Paduraru, Ana Alexandra Dragomir, Angela Pavel, Radu Grada, Sebastian Mihu, Alin Gabriel Ursoniu, Sorin Olariu, Tudor Rares |
author_facet | Lupu, Maria Alina Lighezan, Rodica Paduraru, Ana Alexandra Dragomir, Angela Pavel, Radu Grada, Sebastian Mihu, Alin Gabriel Ursoniu, Sorin Olariu, Tudor Rares |
author_sort | Lupu, Maria Alina |
collection | PubMed |
description | Background: Toxoplasma gondii is estimated to infect 33% of blood donors worldwide, and seroprevalence varies widely between countries. We aimed to evaluate, for the first time, the seroprevalence and risk factors associated with T. gondii in blood donors from Western Romania. Methods: Serologic testing to demonstrate the presence of T. gondii antibodies was conducted in 1347 healthy blood donors. Risk factors for T. gondii infection were assessed through an epidemiological questionnaire. Results: The overall prevalence of T. gondii antibodies was 45.9%, with a significant age-associated increase (p < 0.001) from 32.6% in age group 18–25 years to 67.6% in age group 56–63 years. T. gondii seroprevalence decreased with increasing level of education, from 64.3% in individuals who graduated from elementary/middle school to 40.4% in those who graduated from University (p < 0.001). The multiple logistic regression analysis revealed that age, level of education and having pets (cats and/or dogs) were significantly associated with T. gondii infection. Conclusions: This study brings new and valuable data regarding the seroepidemiology of T. gondii infection in Romania. Our findings indicate a high prevalence of T. gondii antibodies in blood donors and may serve as a starting point for further epidemiological studies that should lead to implementation of prevention programs for toxoplasmosis. |
format | Online Article Text |
id | pubmed-9143041 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91430412022-05-29 Seroepidemiology of Toxoplasma gondii Infection in Blood Donors from Western Romania Lupu, Maria Alina Lighezan, Rodica Paduraru, Ana Alexandra Dragomir, Angela Pavel, Radu Grada, Sebastian Mihu, Alin Gabriel Ursoniu, Sorin Olariu, Tudor Rares Microorganisms Article Background: Toxoplasma gondii is estimated to infect 33% of blood donors worldwide, and seroprevalence varies widely between countries. We aimed to evaluate, for the first time, the seroprevalence and risk factors associated with T. gondii in blood donors from Western Romania. Methods: Serologic testing to demonstrate the presence of T. gondii antibodies was conducted in 1347 healthy blood donors. Risk factors for T. gondii infection were assessed through an epidemiological questionnaire. Results: The overall prevalence of T. gondii antibodies was 45.9%, with a significant age-associated increase (p < 0.001) from 32.6% in age group 18–25 years to 67.6% in age group 56–63 years. T. gondii seroprevalence decreased with increasing level of education, from 64.3% in individuals who graduated from elementary/middle school to 40.4% in those who graduated from University (p < 0.001). The multiple logistic regression analysis revealed that age, level of education and having pets (cats and/or dogs) were significantly associated with T. gondii infection. Conclusions: This study brings new and valuable data regarding the seroepidemiology of T. gondii infection in Romania. Our findings indicate a high prevalence of T. gondii antibodies in blood donors and may serve as a starting point for further epidemiological studies that should lead to implementation of prevention programs for toxoplasmosis. MDPI 2022-05-05 /pmc/articles/PMC9143041/ /pubmed/35630416 http://dx.doi.org/10.3390/microorganisms10050973 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lupu, Maria Alina Lighezan, Rodica Paduraru, Ana Alexandra Dragomir, Angela Pavel, Radu Grada, Sebastian Mihu, Alin Gabriel Ursoniu, Sorin Olariu, Tudor Rares Seroepidemiology of Toxoplasma gondii Infection in Blood Donors from Western Romania |
title | Seroepidemiology of Toxoplasma gondii Infection in Blood Donors from Western Romania |
title_full | Seroepidemiology of Toxoplasma gondii Infection in Blood Donors from Western Romania |
title_fullStr | Seroepidemiology of Toxoplasma gondii Infection in Blood Donors from Western Romania |
title_full_unstemmed | Seroepidemiology of Toxoplasma gondii Infection in Blood Donors from Western Romania |
title_short | Seroepidemiology of Toxoplasma gondii Infection in Blood Donors from Western Romania |
title_sort | seroepidemiology of toxoplasma gondii infection in blood donors from western romania |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143041/ https://www.ncbi.nlm.nih.gov/pubmed/35630416 http://dx.doi.org/10.3390/microorganisms10050973 |
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