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Enhancing Dissolution and Oral Bioavailability of Ursodeoxycholic Acid with a Spray-Dried pH-Modified Extended Release Formulation

Ursodeoxycholate (UDCA) has low oral bioavailability and pH-dependent solubility and permeability. Thus, we developed a pH-modified extended-release formulation of UDCA using Na(2)CO(3) as the alkalizing agent and hydroxypropyl methylcellulose (HPMC) as the release-modifying agent. The optimized pH-...

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Detalles Bibliográficos
Autores principales:	Lee, Jaehyeok, Lee, Chul Haeng, Lee, Jong-Geon, Jeon, So Yeon, Choi, Min-Koo, Song, Im-Sook
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143058/ https://www.ncbi.nlm.nih.gov/pubmed/35631622 http://dx.doi.org/10.3390/pharmaceutics14051037

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