Antiproliferative Effect of Phellodendron amurense Rupr. Based on Angiogenesis

Phellodendron amurense Rupr. is medicinal plant used for supplemental therapy of various diseases based on their positive biological activities. The aim of this study was evaluated the main metabolite, safety of application and anticancer potential. Berberine was determined by HPLC as main alkaloid....

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Autores principales: Balážová, Ľudmila, Kurhajec, Slavomír, Kello, Martin, Bedlovičová, Zdenka, Zigová, Martina, Petrovová, Eva, Beňová, Katarína, Mojžiš, Ján, Eftimová, Jarmila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143060/
https://www.ncbi.nlm.nih.gov/pubmed/35629433
http://dx.doi.org/10.3390/life12050767
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author Balážová, Ľudmila
Kurhajec, Slavomír
Kello, Martin
Bedlovičová, Zdenka
Zigová, Martina
Petrovová, Eva
Beňová, Katarína
Mojžiš, Ján
Eftimová, Jarmila
author_facet Balážová, Ľudmila
Kurhajec, Slavomír
Kello, Martin
Bedlovičová, Zdenka
Zigová, Martina
Petrovová, Eva
Beňová, Katarína
Mojžiš, Ján
Eftimová, Jarmila
author_sort Balážová, Ľudmila
collection PubMed
description Phellodendron amurense Rupr. is medicinal plant used for supplemental therapy of various diseases based on their positive biological activities. The aim of this study was evaluated the main metabolite, safety of application and anticancer potential. Berberine was determined by HPLC as main alkaloid. Harmful character was determined by irritation test in ovo. The potential cancerogenic effect was studied in vitro on a cellular level, in ovo by CAM assay and in vivo on whole organism Artemia franciscana. Extract from the bark of Phellodendron amurense showed antiproliferative and antiangiogenic effects. The results of our work showed promising anticancer effects based also on the inhibition of angiogenesis with minimum negative effects.
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spelling pubmed-91430602022-05-29 Antiproliferative Effect of Phellodendron amurense Rupr. Based on Angiogenesis Balážová, Ľudmila Kurhajec, Slavomír Kello, Martin Bedlovičová, Zdenka Zigová, Martina Petrovová, Eva Beňová, Katarína Mojžiš, Ján Eftimová, Jarmila Life (Basel) Article Phellodendron amurense Rupr. is medicinal plant used for supplemental therapy of various diseases based on their positive biological activities. The aim of this study was evaluated the main metabolite, safety of application and anticancer potential. Berberine was determined by HPLC as main alkaloid. Harmful character was determined by irritation test in ovo. The potential cancerogenic effect was studied in vitro on a cellular level, in ovo by CAM assay and in vivo on whole organism Artemia franciscana. Extract from the bark of Phellodendron amurense showed antiproliferative and antiangiogenic effects. The results of our work showed promising anticancer effects based also on the inhibition of angiogenesis with minimum negative effects. MDPI 2022-05-21 /pmc/articles/PMC9143060/ /pubmed/35629433 http://dx.doi.org/10.3390/life12050767 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Balážová, Ľudmila
Kurhajec, Slavomír
Kello, Martin
Bedlovičová, Zdenka
Zigová, Martina
Petrovová, Eva
Beňová, Katarína
Mojžiš, Ján
Eftimová, Jarmila
Antiproliferative Effect of Phellodendron amurense Rupr. Based on Angiogenesis
title Antiproliferative Effect of Phellodendron amurense Rupr. Based on Angiogenesis
title_full Antiproliferative Effect of Phellodendron amurense Rupr. Based on Angiogenesis
title_fullStr Antiproliferative Effect of Phellodendron amurense Rupr. Based on Angiogenesis
title_full_unstemmed Antiproliferative Effect of Phellodendron amurense Rupr. Based on Angiogenesis
title_short Antiproliferative Effect of Phellodendron amurense Rupr. Based on Angiogenesis
title_sort antiproliferative effect of phellodendron amurense rupr. based on angiogenesis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143060/
https://www.ncbi.nlm.nih.gov/pubmed/35629433
http://dx.doi.org/10.3390/life12050767
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