Cargando…

Analysis of S-Adenosylmethionine and S-Adenosylhomocysteine: Method Optimisation and Profiling in Healthy Adults upon Short-Term Dietary Intervention

S-adenosylmethionine (SAM) is essential for methyl transfer reactions. All SAM is produced de novo via the methionine cycle. The demethylation of SAM produces S-adenosylhomocysteine (SAH), an inhibitor of methyltransferases and the precursor of homocysteine (Hcy). The measurement of SAM and SAH in p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bravo, Aida Corrillero, Aguilera, Maria Nieves Ligero, Marziali, Nahuel R., Moritz, Lennart, Wingert, Victoria, Klotz, Katharina, Schumann, Anke, Grünert, Sarah C., Spiekerkoetter, Ute, Berger, Urs, Lederer, Ann-Kathrin, Huber, Roman, Hannibal, Luciana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143066/ https://www.ncbi.nlm.nih.gov/pubmed/35629877 http://dx.doi.org/10.3390/metabo12050373

Ejemplares similares

S-adenosylhomocysteine hydrolase over-expression does not alter S-adenosylmethionine or S-adenosylhomocysteine levels in CBS deficient mice
por: Lee, Hyung-Ok, et al.
Publicado: (2018)

Higher S-adenosylhomocysteine and lower ratio of S-adenosylmethionine to S-adenosylhomocysteine were more closely associated with increased risk of subclinical atherosclerosis than homocysteine
por: Xiao, Jinghe, et al.
Publicado: (2022)

S-adenosylmethionine and S-adenosylhomocysteine levels in the aging brain of APP/PS1 Alzheimer mice
por: Hooijmans, Carlijn R., et al.
Publicado: (2009)

Determination of S-Adenosylmethionine and S-Adenosylhomocysteine by LC–MS/MS and evaluation of their stability in mice tissues
por: Krijt, Jakub, et al.
Publicado: (2009)

Immunoassay of S-adenosylmethionine and S-adenosylhomocysteine: the methylation index as a biomarker for disease and health status
por: Hao, Xiujuan, et al.
Publicado: (2016)

S-Adenosylmethionine Deficiency and Brain Accumulation of S-Adenosylhomocysteine in Thioacetamide-Induced Acute Liver Failure
por: Czarnecka, Anna Maria, et al.
Publicado: (2020)

Association of serum s-adenosylmethionine, s-adenosylhomocysteine, and their ratio with the risk of dementia and death in a community
por: Mihara, Akane, et al.
Publicado: (2022)

Metabolic Profiling in Human Fibroblasts Enables Subtype Clustering in Glycogen Storage Disease
por: Hannibal, Luciana, et al.
Publicado: (2020)

Successful pregnancy in a woman with glycogen storage disease type 6
por: Grünert, Sarah Catharina, et al.
Publicado: (2021)

Targeted Metabolic Profiling of Methionine Cycle Metabolites and Redox Thiol Pools in Mammalian Plasma, Cells and Urine
por: Behringer, Sidney, et al.
Publicado: (2019)

Severe loss of appetite and refusal to eat as severe side effect of glycerol phenylbutyrate
por: Grünert, Sarah Catharina, et al.
Publicado: (2022)

The Phenotypic and Genetic Spectrum of Glycogen Storage Disease Type VI
por: Grünert, Sarah Catharina, et al.
Publicado: (2021)

The impact of metabolic stressors on mitochondrial homeostasis in a renal epithelial cell model of methylmalonic aciduria
por: Schumann, Anke, et al.
Publicado: (2023)

Unsuccessful intravenous D-mannose treatment in PMM2-CDG
por: Grünert, Sarah C., et al.
Publicado: (2019)

Transiently elevated plasma methionine, S‐adenosylmethionine and S‐adenosylhomocysteine: Unreported laboratory findings in a patient with NGLY1 deficiency, a congenital disorder of deglycosylation
por: Chang, Caitlin A., et al.
Publicado: (2019)

Identification and Characterization of a Novel Splice Site Mutation Associated with Glycogen Storage Disease Type VI in Two Unrelated Turkish Families
por: Grünert, Sarah C., et al.
Publicado: (2021)

Improved inflammatory bowel disease, wound healing and normal oxidative burst under treatment with empagliflozin in glycogen storage disease type Ib
por: Grünert, Sarah C., et al.
Publicado: (2020)

Intracerebral Administration of S-Adenosylhomocysteine or S-Adenosylmethionine Attenuates the Increases in the Cortical Extracellular Levels of Dimethylarginines Without Affecting cGMP Level in Rats with Acute Liver Failure
por: Czarnecka, Anna, et al.
Publicado: (2016)

Three successful pregnancies in a patient with glycogen storage disease type 0
por: Grünert, Sarah C., et al.
Publicado: (2020)

Successful pregnancy in maple syrup urine disease: a case report and review of the literature
por: Grünert, Sarah Catharina, et al.
Publicado: (2018)

Evidence for a Genotype–Phenotype Correlation in Patients with Pathogenic GLUT2 (SLC2A2) Variants
por: Grünert, Sarah C., et al.
Publicado: (2021)

Riboflavin 1 Transporter Deficiency: Novel SLC52A1 Variants and Expansion of the Phenotypic Spectrum
por: Grünert, Sarah C., et al.
Publicado: (2023)

Two successful pregnancies and first use of empagliflozin during pregnancy in glycogen storage disease type Ib
por: Grünert, Sarah Catharina, et al.
Publicado: (2022)

Regulation of homocysteine metabolism by Mycobacterium tuberculosis S-adenosylhomocysteine hydrolase
por: Singhal, Anshika, et al.
Publicado: (2013)

Alteration of S‐adenosylhomocysteine levels affects lignin biosynthesis in switchgrass
por: Bai, Zetao, et al.
Publicado: (2018)

The biochemical profile and dietary management in S-adenosylhomocysteine hydrolase deficiency
por: Huang, Yue, et al.
Publicado: (2022)

Primary carnitine deficiency – diagnosis after heart transplantation: better late than never!
por: Grünert, Sarah C., et al.
Publicado: (2020)

Reversible sensory neuropathy in mitochondrial trifunctional protein deficiency
por: Grünert, Sarah Catharina, et al.
Publicado: (2022)

The Biochemistry of Adenosylmethionine
por: Kraus, Jan
Publicado: (1978)

Isolated Hypomethylation of IGF2 Associated with Severe Hypoglycemia Responsive to Growth Hormone Treatment
por: Grünert, Sarah C., et al.
Publicado: (2021)

Biomarkers and Algorithms for the Diagnosis of Vitamin B(12) Deficiency
por: Hannibal, Luciana, et al.
Publicado: (2016)

Corrigendum: Biomarkers and Algorithms for the Diagnosis of Vitamin B(12) Deficiency
por: Hannibal, Luciana, et al.
Publicado: (2017)

Role of Elevated Intracellular S-Adenosylhomocysteine in the Pathogenesis of Alcohol-Related Liver Disease
por: Arumugam, Madan Kumar, et al.
Publicado: (2020)

Radical S-Adenosylmethionine Enzymes
por: Broderick, Joan B., et al.
Publicado: (2014)

Abnormal Hypermethylation at Imprinting Control Regions in Patients with S-Adenosylhomocysteine Hydrolase (AHCY) Deficiency
por: Motzek, Antje, et al.
Publicado: (2016)

Intracellular homocysteine metabolites in SLE: plasma S-adenosylhomocysteine correlates with coronary plaque burden
por: Stojan, George, et al.
Publicado: (2021)

Elevated S-adenosylhomocysteine induces adipocyte dysfunction to promote alcohol-associated liver steatosis
por: Arumugam, Madan Kumar, et al.
Publicado: (2021)

Insufficient S-adenosylhomocysteine hydrolase compromises the beneficial effect of diabetic BMSCs on diabetic cardiomyopathy
por: Wang, Ying, et al.
Publicado: (2022)

Effects of S-Adenosylhomocysteine Hydrolase Downregulation on Wnt Signaling Pathway in SW480 Cells
por: Pavičić, Ivana, et al.
Publicado: (2023)

Biosynthesis, Quantification and Genetic Diseases of the Smallest Signaling Thiol Metabolite: Hydrogen Sulfide
por: Myszkowska, Joanna, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_7prmirq3birllb6j52j8675pv6