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Flow Regulation Performance Analysis of Microfluidic Passive Valve for High Throughput Liquid Delivery

A microfluidic passive valve (MPV) is important for precise flow control, and it determines the reliability of the microfluidic system. In this paper, a novel MPV capable of delivering a constant flow rate independently of inlet pressure changes is proposed. The flow rate of the MPV is adjusted by t...

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Detalles Bibliográficos
Autores principales: Su, Qi, Chen, Weiran, Chen, Weiping, Jin, Zhijiang, Lin, Zhenhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143073/
https://www.ncbi.nlm.nih.gov/pubmed/35630154
http://dx.doi.org/10.3390/mi13050687
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author Su, Qi
Chen, Weiran
Chen, Weiping
Jin, Zhijiang
Lin, Zhenhao
author_facet Su, Qi
Chen, Weiran
Chen, Weiping
Jin, Zhijiang
Lin, Zhenhao
author_sort Su, Qi
collection PubMed
description A microfluidic passive valve (MPV) is important for precise flow control, and it determines the reliability of the microfluidic system. In this paper, a novel MPV capable of delivering a constant flow rate independently of inlet pressure changes is proposed. The flow rate of the MPV is adjusted by the difference between the fluid force on the upper surface of the valve core and the spring force. The constant flow rate of the MPV is maintained by automatically changing the size of the gap channel formed by the groove on the valve core and the baffle on the valve body. The nearly constant flow rate of the MPV is 6.26 mL/min, with a variation of 6.5% under the inlet pressure varied from 1.25 kPa to 3.5 kPa. In addition, the flow characteristics of the MPV are analyzed by numerical simulation. With the increase in the inlet pressure, the maximum velocity gradually increases, while the increment of the maximum velocity decreases. In the movement process of the valve core, the region of pressure drop becomes larger. This work has a certain reference value for the design and research of the MPVs with high throughput liquid delivery.
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spelling pubmed-91430732022-05-29 Flow Regulation Performance Analysis of Microfluidic Passive Valve for High Throughput Liquid Delivery Su, Qi Chen, Weiran Chen, Weiping Jin, Zhijiang Lin, Zhenhao Micromachines (Basel) Article A microfluidic passive valve (MPV) is important for precise flow control, and it determines the reliability of the microfluidic system. In this paper, a novel MPV capable of delivering a constant flow rate independently of inlet pressure changes is proposed. The flow rate of the MPV is adjusted by the difference between the fluid force on the upper surface of the valve core and the spring force. The constant flow rate of the MPV is maintained by automatically changing the size of the gap channel formed by the groove on the valve core and the baffle on the valve body. The nearly constant flow rate of the MPV is 6.26 mL/min, with a variation of 6.5% under the inlet pressure varied from 1.25 kPa to 3.5 kPa. In addition, the flow characteristics of the MPV are analyzed by numerical simulation. With the increase in the inlet pressure, the maximum velocity gradually increases, while the increment of the maximum velocity decreases. In the movement process of the valve core, the region of pressure drop becomes larger. This work has a certain reference value for the design and research of the MPVs with high throughput liquid delivery. MDPI 2022-04-28 /pmc/articles/PMC9143073/ /pubmed/35630154 http://dx.doi.org/10.3390/mi13050687 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Su, Qi
Chen, Weiran
Chen, Weiping
Jin, Zhijiang
Lin, Zhenhao
Flow Regulation Performance Analysis of Microfluidic Passive Valve for High Throughput Liquid Delivery
title Flow Regulation Performance Analysis of Microfluidic Passive Valve for High Throughput Liquid Delivery
title_full Flow Regulation Performance Analysis of Microfluidic Passive Valve for High Throughput Liquid Delivery
title_fullStr Flow Regulation Performance Analysis of Microfluidic Passive Valve for High Throughput Liquid Delivery
title_full_unstemmed Flow Regulation Performance Analysis of Microfluidic Passive Valve for High Throughput Liquid Delivery
title_short Flow Regulation Performance Analysis of Microfluidic Passive Valve for High Throughput Liquid Delivery
title_sort flow regulation performance analysis of microfluidic passive valve for high throughput liquid delivery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143073/
https://www.ncbi.nlm.nih.gov/pubmed/35630154
http://dx.doi.org/10.3390/mi13050687
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