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Flow Regulation Performance Analysis of Microfluidic Passive Valve for High Throughput Liquid Delivery
A microfluidic passive valve (MPV) is important for precise flow control, and it determines the reliability of the microfluidic system. In this paper, a novel MPV capable of delivering a constant flow rate independently of inlet pressure changes is proposed. The flow rate of the MPV is adjusted by t...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143073/ https://www.ncbi.nlm.nih.gov/pubmed/35630154 http://dx.doi.org/10.3390/mi13050687 |
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author | Su, Qi Chen, Weiran Chen, Weiping Jin, Zhijiang Lin, Zhenhao |
author_facet | Su, Qi Chen, Weiran Chen, Weiping Jin, Zhijiang Lin, Zhenhao |
author_sort | Su, Qi |
collection | PubMed |
description | A microfluidic passive valve (MPV) is important for precise flow control, and it determines the reliability of the microfluidic system. In this paper, a novel MPV capable of delivering a constant flow rate independently of inlet pressure changes is proposed. The flow rate of the MPV is adjusted by the difference between the fluid force on the upper surface of the valve core and the spring force. The constant flow rate of the MPV is maintained by automatically changing the size of the gap channel formed by the groove on the valve core and the baffle on the valve body. The nearly constant flow rate of the MPV is 6.26 mL/min, with a variation of 6.5% under the inlet pressure varied from 1.25 kPa to 3.5 kPa. In addition, the flow characteristics of the MPV are analyzed by numerical simulation. With the increase in the inlet pressure, the maximum velocity gradually increases, while the increment of the maximum velocity decreases. In the movement process of the valve core, the region of pressure drop becomes larger. This work has a certain reference value for the design and research of the MPVs with high throughput liquid delivery. |
format | Online Article Text |
id | pubmed-9143073 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91430732022-05-29 Flow Regulation Performance Analysis of Microfluidic Passive Valve for High Throughput Liquid Delivery Su, Qi Chen, Weiran Chen, Weiping Jin, Zhijiang Lin, Zhenhao Micromachines (Basel) Article A microfluidic passive valve (MPV) is important for precise flow control, and it determines the reliability of the microfluidic system. In this paper, a novel MPV capable of delivering a constant flow rate independently of inlet pressure changes is proposed. The flow rate of the MPV is adjusted by the difference between the fluid force on the upper surface of the valve core and the spring force. The constant flow rate of the MPV is maintained by automatically changing the size of the gap channel formed by the groove on the valve core and the baffle on the valve body. The nearly constant flow rate of the MPV is 6.26 mL/min, with a variation of 6.5% under the inlet pressure varied from 1.25 kPa to 3.5 kPa. In addition, the flow characteristics of the MPV are analyzed by numerical simulation. With the increase in the inlet pressure, the maximum velocity gradually increases, while the increment of the maximum velocity decreases. In the movement process of the valve core, the region of pressure drop becomes larger. This work has a certain reference value for the design and research of the MPVs with high throughput liquid delivery. MDPI 2022-04-28 /pmc/articles/PMC9143073/ /pubmed/35630154 http://dx.doi.org/10.3390/mi13050687 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Su, Qi Chen, Weiran Chen, Weiping Jin, Zhijiang Lin, Zhenhao Flow Regulation Performance Analysis of Microfluidic Passive Valve for High Throughput Liquid Delivery |
title | Flow Regulation Performance Analysis of Microfluidic Passive Valve for High Throughput Liquid Delivery |
title_full | Flow Regulation Performance Analysis of Microfluidic Passive Valve for High Throughput Liquid Delivery |
title_fullStr | Flow Regulation Performance Analysis of Microfluidic Passive Valve for High Throughput Liquid Delivery |
title_full_unstemmed | Flow Regulation Performance Analysis of Microfluidic Passive Valve for High Throughput Liquid Delivery |
title_short | Flow Regulation Performance Analysis of Microfluidic Passive Valve for High Throughput Liquid Delivery |
title_sort | flow regulation performance analysis of microfluidic passive valve for high throughput liquid delivery |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143073/ https://www.ncbi.nlm.nih.gov/pubmed/35630154 http://dx.doi.org/10.3390/mi13050687 |
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