Cargando…

Exploring the Activity of Fungal Phenalenone Derivatives as Potential CK2 Inhibitors Using Computational Methods

Cancer represents one of the most prevalent causes of global death. CK2 (casein kinase 2) activation boosted cancer proliferation and progression. Therefore, CK2 inhibition can have a crucial role in prohibiting cancer progression and enhancing apoptosis. Fungi have gained vast interest as a wealthy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ibrahim, Sabrin R. M., Bagalagel, Alaa A., Diri, Reem M., Noor, Ahmad O., Bakhsh, Hussain T., Muhammad, Yosra A., Mohamed, Gamal A., Omar, Abdelsattar M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143076/ https://www.ncbi.nlm.nih.gov/pubmed/35628699 http://dx.doi.org/10.3390/jof8050443

Ejemplares similares

Phytoconstituents and Pharmacological Activities of Indian Camphorweed (Pluchea indica): A Multi-Potential Medicinal Plant of Nutritional and Ethnomedicinal Importance
por: Ibrahim, Sabrin R. M., et al.
Publicado: (2022)

Thiophenes—Naturally Occurring Plant Metabolites: Biological Activities and In Silico Evaluation of Their Potential as Cathepsin D Inhibitors
por: Ibrahim, Sabrin R. M., et al.
Publicado: (2022)

Curative effects of fucoidan on acetic acid induced ulcerative colitis in rats via modulating aryl hydrocarbon receptor and phosphodiesterase-4
por: Bagalagel, Alaa, et al.
Publicado: (2022)

Evaluating the Anticancer Activity of Blocking TNF Type 1 Receptors in Thioacetamide-Induced Hepatocellular Carcinoma in a Rat Model
por: Bagalagel, Alaa, et al.
Publicado: (2022)

Fungal Bergamotane Sesquiterpenoids—Potential Metabolites: Sources, Bioactivities, and Biosynthesis
por: Khayat, Maan T., et al.
Publicado: (2022)

Genistein ameliorated experimentally induced gastric ulcer in rats via inhibiting gastric tissues fibrosis by modulating Wnt/β-catenin/TGF-β/PKB pathway
por: Hassan, Hanan M., et al.
Publicado: (2023)

Advances in Fungal Phenaloenones—Natural Metabolites with Great Promise: Biosynthesis, Bioactivities, and an In Silico Evaluation of Their Potential as Human Glucose Transporter 1 Inhibitors
por: Ibrahim, Sabrin R. M., et al.
Publicado: (2022)

Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities
por: Noor, Ahmad Omar, et al.
Publicado: (2020)

Commonly used agent for acute pain management of sickle cell anemia in Saudi Emergency Department: A narrative review
por: Hejazi, Reem A., et al.
Publicado: (2021)

Chaetomugilins and Chaetoviridins—Promising Natural Metabolites: Structures, Separation, Characterization, Biosynthesis, Bioactivities, Molecular Docking, and Molecular Dynamics
por: Omar, Abdelsattar M., et al.
Publicado: (2022)

The Natural Polypeptides as Significant Elastase Inhibitors
por: Ahmad, Shabir, et al.
Publicado: (2020)

Application of the Crystalline Sponge Method to Revise the Structure of the Phenalenone Fuliginone
por: Brkljača, Robert, et al.
Publicado: (2017)

Phenalenones from a Marine-Derived Fungus Penicillium sp.
por: Park, Sung Chul, et al.
Publicado: (2019)

Unusual Nitrogenous Phenalenone Derivatives from the Marine-Derived Fungus Coniothyrium cereale
por: Elsebai, Mahmoud Fahmi, et al.
Publicado: (2016)

Selective cytotoxic activity and protective effects of sodium ascorbate against hepatocellular carcinoma through its effect on oxidative stress and apoptosis in vivo and in vitro
por: El-Far, Yousra M., et al.
Publicado: (2020)

Development of Phenalenone-Triazolium Salt Derivatives for aPDT: Synthesis and Antibacterial Screening
por: Godard, Jérémy, et al.
Publicado: (2021)

Fungal Depsides—Naturally Inspiring Molecules: Biosynthesis, Structural Characterization, and Biological Activities
por: Ibrahim, Sabrin R. M., et al.
Publicado: (2021)

New Phenalenone Derivatives: Synthesis and Evaluation of Their Singlet Oxygen Quantum Yield
por: Godard, Jérémy, et al.
Publicado: (2020)

Docking and Molecular Dynamic Investigations of Phenylspirodrimanes as Cannabinoid Receptor-2 Agonists
por: Omar, Abdelsattar M., et al.
Publicado: (2022)

Unveiling the Efficacy of Sesquiterpenes from Marine Sponge Dactylospongia elegans in Inhibiting Dihydrofolate Reductase Using Docking and Molecular Dynamic Studies
por: Omar, Abdelsattar M., et al.
Publicado: (2023)

Thymoquinone therapy remediates elevated brain tissue inflammatory mediators induced by chronic administration of food preservatives
por: Hamdan, Ahmed Mohsen, et al.
Publicado: (2019)

Author Correction: Thymoquinone therapy remediates elevated brain tissue inflammatory mediators induced by chronic administration of food preservatives
por: Hamdan, Ahmed Mohsen, et al.
Publicado: (2019)

Assessments of Alpha-Amylase Inhibitory Potential of Tagetes Flavonoids through In Vitro, Molecular Docking, and Molecular Dynamics Simulation Studies
por: Mohamed, Gamal A., et al.
Publicado: (2023)

Mangosteen Metabolites as Promising Alpha-Amylase Inhibitor Candidates: In Silico and In Vitro Evaluations
por: Omar, Abdelsattar M., et al.
Publicado: (2022)

Alpha-Glucosidase- and Lipase-Inhibitory Phenalenones from a New Species of Pseudolophiostoma Originating from Thailand
por: Macabeo, Allan Patrick G., et al.
Publicado: (2020)

Phytoalexin Phenalenone Derivatives Inactivate Mosquito Larvae and Root-knot Nematode as Type-II Photosensitizer
por: Song, Runjiang, et al.
Publicado: (2017)

Preservation of the donor–acceptor character of a carbazole–phenalenone dyad upon adsorption on Pt(111)
por: Ebeling, René, et al.
Publicado: (2020)

Behavioral Changes in Gym Attending Due to COVID-19 Pandemic: A Descriptive Survey
por: Almasri, Diena, et al.
Publicado: (2020)

Structure-Based Virtual Screening and Molecular Dynamics Simulation Assessments of Depsidones as Possible Selective Cannabinoid Receptor Type 2 Agonists
por: Mohamed, Gamal A., et al.
Publicado: (2023)

Mining of Marburg Virus Proteome for Designing an Epitope-Based Vaccine
por: Soltan, Mohamed A., et al.
Publicado: (2022)

Fungal Naphthalenones; Promising Metabolites for Drug Discovery: Structures, Biosynthesis, Sources, and Pharmacological Potential
por: Ibrahim, Sabrin R. M., et al.
Publicado: (2022)

Association of Demographic Variables with the Awareness of Type 2 Diabetes Mellitus Patients (T2DM) among the Northwest Population in Saudi Arabia
por: Al Arawi, Wael Ahmed, et al.
Publicado: (2020)

Phyto-Phospholipid Conjugated Scorpion Venom Nanovesicles as Promising Carrier That Improves Efficacy of Thymoquinone against Adenocarcinoma Human Alveolar Basal Epithelial Cells
por: Asfour, Hani Z., et al.
Publicado: (2021)

Fe(III), Cu(II) and Zn(II) Complexes of the Rigid 9-Oxido-phenalenone Ligand—Spectroscopy, Electrochemistry, and Cytotoxic Properties
por: Butsch, Katharina, et al.
Publicado: (2021)

Exploring the CK2 Paradox: Restless, Dangerous, Dispensable
por: Franchin, Cinzia, et al.
Publicado: (2017)

Untapped Potential of Marine-Associated Cladosporium Species: An Overview on Secondary Metabolites, Biotechnological Relevance, and Biological Activities
por: Mohamed, Gamal A., et al.
Publicado: (2021)

Garcixanthone E and Garcimangophenone C: New Metabolites from Garcinia mangostana and Their Cytotoxic and Alpha Amylase Inhibitory Potential
por: Mohamed, Gamal A., et al.
Publicado: (2022)

Paradigm Shift in Drug Re-purposing From Phenalenone to Phenaleno-Furanone to Combat Multi-Drug Resistant Salmonella enterica Serovar Typhi
por: Mujawar, Shama, et al.
Publicado: (2018)

Metabolic Profiling and Investigation of the Modulatory Effect of Fagonia cretica L. Aerial Parts on Hepatic CYP3A4 and UGT2B7 Enzymes in Streptozotocin—Induced Diabetic Model
por: Kamran, Shahzad, et al.
Publicado: (2023)

The Impact of COVID-19 Outbreak on Reassessing the Need for Drive Thru Community Pharmacy: Cross-Sectional Study
por: Diri, Reem M.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_3o9detj478l2t7c8p1ptbhh8k7