Application of 3D-Printed, PLGA-Based Scaffolds in Bone Tissue Engineering

Polylactic acid–glycolic acid (PLGA) has been widely used in bone tissue engineering due to its favorable biocompatibility and adjustable biodegradation. 3D printing technology can prepare scaffolds with rich structure and function, and is one of the best methods to obtain scaffolds for bone tissue...

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Autores principales: Sun, Fengbo, Sun, Xiaodan, Wang, Hetong, Li, Chunxu, Zhao, Yu, Tian, Jingjing, Lin, Yuanhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143187/
https://www.ncbi.nlm.nih.gov/pubmed/35628638
http://dx.doi.org/10.3390/ijms23105831
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author Sun, Fengbo
Sun, Xiaodan
Wang, Hetong
Li, Chunxu
Zhao, Yu
Tian, Jingjing
Lin, Yuanhua
author_facet Sun, Fengbo
Sun, Xiaodan
Wang, Hetong
Li, Chunxu
Zhao, Yu
Tian, Jingjing
Lin, Yuanhua
author_sort Sun, Fengbo
collection PubMed
description Polylactic acid–glycolic acid (PLGA) has been widely used in bone tissue engineering due to its favorable biocompatibility and adjustable biodegradation. 3D printing technology can prepare scaffolds with rich structure and function, and is one of the best methods to obtain scaffolds for bone tissue repair. This review systematically summarizes the research progress of 3D-printed, PLGA-based scaffolds. The properties of the modified components of scaffolds are introduced in detail. The influence of structure and printing method change in printing process is analyzed. The advantages and disadvantages of their applications are illustrated by several examples. Finally, we briefly discuss the limitations and future development direction of current 3D-printed, PLGA-based materials for bone tissue repair.
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spelling pubmed-91431872022-05-29 Application of 3D-Printed, PLGA-Based Scaffolds in Bone Tissue Engineering Sun, Fengbo Sun, Xiaodan Wang, Hetong Li, Chunxu Zhao, Yu Tian, Jingjing Lin, Yuanhua Int J Mol Sci Review Polylactic acid–glycolic acid (PLGA) has been widely used in bone tissue engineering due to its favorable biocompatibility and adjustable biodegradation. 3D printing technology can prepare scaffolds with rich structure and function, and is one of the best methods to obtain scaffolds for bone tissue repair. This review systematically summarizes the research progress of 3D-printed, PLGA-based scaffolds. The properties of the modified components of scaffolds are introduced in detail. The influence of structure and printing method change in printing process is analyzed. The advantages and disadvantages of their applications are illustrated by several examples. Finally, we briefly discuss the limitations and future development direction of current 3D-printed, PLGA-based materials for bone tissue repair. MDPI 2022-05-23 /pmc/articles/PMC9143187/ /pubmed/35628638 http://dx.doi.org/10.3390/ijms23105831 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sun, Fengbo
Sun, Xiaodan
Wang, Hetong
Li, Chunxu
Zhao, Yu
Tian, Jingjing
Lin, Yuanhua
Application of 3D-Printed, PLGA-Based Scaffolds in Bone Tissue Engineering
title Application of 3D-Printed, PLGA-Based Scaffolds in Bone Tissue Engineering
title_full Application of 3D-Printed, PLGA-Based Scaffolds in Bone Tissue Engineering
title_fullStr Application of 3D-Printed, PLGA-Based Scaffolds in Bone Tissue Engineering
title_full_unstemmed Application of 3D-Printed, PLGA-Based Scaffolds in Bone Tissue Engineering
title_short Application of 3D-Printed, PLGA-Based Scaffolds in Bone Tissue Engineering
title_sort application of 3d-printed, plga-based scaffolds in bone tissue engineering
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143187/
https://www.ncbi.nlm.nih.gov/pubmed/35628638
http://dx.doi.org/10.3390/ijms23105831
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