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Primate Erythroparvovirus 1 Infection in Patients with Hematological Disorders

Primate erythroparvovirus 1, commonly referred to as Parvovirus B19 (B19V), is a DNA virus that normally results in a mild childhood infection called “erythema infectiosum”. Besides respiratory spread, B19V can also be transmitted through transfusions, which may result in persistent anemia in immuno...

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Autores principales: Krumova, Stefka, Andonova, Ivona, Stefanova, Radostina, Miteva, Polina, Nenkova, Galina, Hübschen, Judith M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143349/
https://www.ncbi.nlm.nih.gov/pubmed/35631017
http://dx.doi.org/10.3390/pathogens11050497
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author Krumova, Stefka
Andonova, Ivona
Stefanova, Radostina
Miteva, Polina
Nenkova, Galina
Hübschen, Judith M.
author_facet Krumova, Stefka
Andonova, Ivona
Stefanova, Radostina
Miteva, Polina
Nenkova, Galina
Hübschen, Judith M.
author_sort Krumova, Stefka
collection PubMed
description Primate erythroparvovirus 1, commonly referred to as Parvovirus B19 (B19V), is a DNA virus that normally results in a mild childhood infection called “erythema infectiosum”. Besides respiratory spread, B19V can also be transmitted through transfusions, which may result in persistent anemia in immunodeficient hosts. Dialysis patients often face acute or chronic anemia after infection with B19V. Here, we describe the laboratory investigation of 21 patients with hematological disorders for B19V infections. B19V DNA was detected in 13 (62%) of them, with specific IgM antibodies in three of the DNA positives. All 13 patients received treatment and were laboratory-monitored over a period of one year. In only two patients (a 14-year-old child with a kidney transplantation and a 39-year-old patient with aplastic anemia), markers of recent B19V infection were still detectable in follow-up samples. For four B19V DNA positive samples, short sequences could be obtained, which clustered with genotype 1a reference strains. Our findings suggest that all cases of hematological disorders should be examined for specific B19V antibodies and DNA for accurate diagnosis and appropriate patient management.
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spelling pubmed-91433492022-05-29 Primate Erythroparvovirus 1 Infection in Patients with Hematological Disorders Krumova, Stefka Andonova, Ivona Stefanova, Radostina Miteva, Polina Nenkova, Galina Hübschen, Judith M. Pathogens Article Primate erythroparvovirus 1, commonly referred to as Parvovirus B19 (B19V), is a DNA virus that normally results in a mild childhood infection called “erythema infectiosum”. Besides respiratory spread, B19V can also be transmitted through transfusions, which may result in persistent anemia in immunodeficient hosts. Dialysis patients often face acute or chronic anemia after infection with B19V. Here, we describe the laboratory investigation of 21 patients with hematological disorders for B19V infections. B19V DNA was detected in 13 (62%) of them, with specific IgM antibodies in three of the DNA positives. All 13 patients received treatment and were laboratory-monitored over a period of one year. In only two patients (a 14-year-old child with a kidney transplantation and a 39-year-old patient with aplastic anemia), markers of recent B19V infection were still detectable in follow-up samples. For four B19V DNA positive samples, short sequences could be obtained, which clustered with genotype 1a reference strains. Our findings suggest that all cases of hematological disorders should be examined for specific B19V antibodies and DNA for accurate diagnosis and appropriate patient management. MDPI 2022-04-21 /pmc/articles/PMC9143349/ /pubmed/35631017 http://dx.doi.org/10.3390/pathogens11050497 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Krumova, Stefka
Andonova, Ivona
Stefanova, Radostina
Miteva, Polina
Nenkova, Galina
Hübschen, Judith M.
Primate Erythroparvovirus 1 Infection in Patients with Hematological Disorders
title Primate Erythroparvovirus 1 Infection in Patients with Hematological Disorders
title_full Primate Erythroparvovirus 1 Infection in Patients with Hematological Disorders
title_fullStr Primate Erythroparvovirus 1 Infection in Patients with Hematological Disorders
title_full_unstemmed Primate Erythroparvovirus 1 Infection in Patients with Hematological Disorders
title_short Primate Erythroparvovirus 1 Infection in Patients with Hematological Disorders
title_sort primate erythroparvovirus 1 infection in patients with hematological disorders
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143349/
https://www.ncbi.nlm.nih.gov/pubmed/35631017
http://dx.doi.org/10.3390/pathogens11050497
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