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Maternal and Fetal Metabolites in Gestational Diabetes Mellitus: A Narrative Review
Gestational diabetes mellitus (GDM) is a major public health issue of our century due to its increasing prevalence, affecting 5% to 20% of all pregnancies. The pathogenesis of GDM has not been completely elucidated to date. Increasing evidence suggests the association of environmental factors with g...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143359/ https://www.ncbi.nlm.nih.gov/pubmed/35629887 http://dx.doi.org/10.3390/metabo12050383 |
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| author | Vladu, Ionela Mihaela Clenciu, Diana Mitrea, Adina Amzolini, Anca Micu, Simona Elena Crisan, Anda Elena Efrem, Ion Cristian Fortofoiu, Maria Fortofoiu, Mircea Catalin Mita, Adrian Barau Alhija, Anca Glodeanu, Adina Dorina Mota, Maria |
| author_facet | Vladu, Ionela Mihaela Clenciu, Diana Mitrea, Adina Amzolini, Anca Micu, Simona Elena Crisan, Anda Elena Efrem, Ion Cristian Fortofoiu, Maria Fortofoiu, Mircea Catalin Mita, Adrian Barau Alhija, Anca Glodeanu, Adina Dorina Mota, Maria |
| author_sort | Vladu, Ionela Mihaela |
| collection | PubMed |
| description | Gestational diabetes mellitus (GDM) is a major public health issue of our century due to its increasing prevalence, affecting 5% to 20% of all pregnancies. The pathogenesis of GDM has not been completely elucidated to date. Increasing evidence suggests the association of environmental factors with genetic and epigenetic factors in the development of GDM. So far, several metabolomics studies have investigated metabolic disruptions associated with GDM. The aim of this review is to highlight the usefulness of maternal metabolites as diagnosis markers of GDM as well as the importance of both maternal and fetal metabolites as prognosis biomarkers for GDM and GDM’s transition to type 2 diabetes mellitus T2DM. |
| format | Online Article Text |
| id | pubmed-9143359 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-91433592022-05-29 Maternal and Fetal Metabolites in Gestational Diabetes Mellitus: A Narrative Review Vladu, Ionela Mihaela Clenciu, Diana Mitrea, Adina Amzolini, Anca Micu, Simona Elena Crisan, Anda Elena Efrem, Ion Cristian Fortofoiu, Maria Fortofoiu, Mircea Catalin Mita, Adrian Barau Alhija, Anca Glodeanu, Adina Dorina Mota, Maria Metabolites Review Gestational diabetes mellitus (GDM) is a major public health issue of our century due to its increasing prevalence, affecting 5% to 20% of all pregnancies. The pathogenesis of GDM has not been completely elucidated to date. Increasing evidence suggests the association of environmental factors with genetic and epigenetic factors in the development of GDM. So far, several metabolomics studies have investigated metabolic disruptions associated with GDM. The aim of this review is to highlight the usefulness of maternal metabolites as diagnosis markers of GDM as well as the importance of both maternal and fetal metabolites as prognosis biomarkers for GDM and GDM’s transition to type 2 diabetes mellitus T2DM. MDPI 2022-04-22 /pmc/articles/PMC9143359/ /pubmed/35629887 http://dx.doi.org/10.3390/metabo12050383 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Review Vladu, Ionela Mihaela Clenciu, Diana Mitrea, Adina Amzolini, Anca Micu, Simona Elena Crisan, Anda Elena Efrem, Ion Cristian Fortofoiu, Maria Fortofoiu, Mircea Catalin Mita, Adrian Barau Alhija, Anca Glodeanu, Adina Dorina Mota, Maria Maternal and Fetal Metabolites in Gestational Diabetes Mellitus: A Narrative Review |
| title | Maternal and Fetal Metabolites in Gestational Diabetes Mellitus: A Narrative Review |
| title_full | Maternal and Fetal Metabolites in Gestational Diabetes Mellitus: A Narrative Review |
| title_fullStr | Maternal and Fetal Metabolites in Gestational Diabetes Mellitus: A Narrative Review |
| title_full_unstemmed | Maternal and Fetal Metabolites in Gestational Diabetes Mellitus: A Narrative Review |
| title_short | Maternal and Fetal Metabolites in Gestational Diabetes Mellitus: A Narrative Review |
| title_sort | maternal and fetal metabolites in gestational diabetes mellitus: a narrative review |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143359/ https://www.ncbi.nlm.nih.gov/pubmed/35629887 http://dx.doi.org/10.3390/metabo12050383 |
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