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Spontaneous Suppressors against Debilitating Transmembrane Mutants of CaMdr1 Disclose Novel Interdomain Communication via Signature Motifs of the Major Facilitator Superfamily

The Major Facilitator Superfamily (MFS) drug:H(+) antiporter CaMdr1, from Candida albicans, is responsible for the efflux of structurally diverse antifungals. MFS members share a common fold of 12–14 transmembrane helices (TMHs) forming two N- and C-domains. Each domain is arranged in a pseudo-symme...

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Detalles Bibliográficos
Autores principales:	Sharma, Suman, Banerjee, Atanu, Moreno, Alexis, Redhu, Archana Kumari, Falson, Pierre, Prasad, Rajendra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143388/ https://www.ncbi.nlm.nih.gov/pubmed/35628792 http://dx.doi.org/10.3390/jof8050538

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