Cargando…

Hypoxia Differently Affects TGF-β2-Induced Epithelial Mesenchymal Transitions in the 2D and 3D Culture of the Human Retinal Pigment Epithelium Cells

The hypoxia associated with the transforming growth factor-β2 (TGF-β2)-induced epithelial mesenchymal transition (EMT) of human retinal pigment epithelium (HRPE) cells is well recognized as the essential underlying mechanism responsible for the development of proliferative retinal diseases. In vitro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Suzuki, Soma, Sato, Tatsuya, Watanabe, Megumi, Higashide, Megumi, Tsugeno, Yuri, Umetsu, Araya, Furuhashi, Masato, Ida, Yosuke, Hikage, Fumihito, Ohguro, Hiroshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143417/ https://www.ncbi.nlm.nih.gov/pubmed/35628282 http://dx.doi.org/10.3390/ijms23105473

Ejemplares similares

All Trans-Retinoic Acids Facilitate the Remodeling of 2D and 3D Cultured Human Conjunctival Fibroblasts
por: Tsugeno, Yuri, et al.
Publicado: (2022)

An α2-Adrenergic Agonist, Brimonidine, Beneficially Affects the TGF-β2-Treated Cellular Properties in an In Vitro Culture Model
por: Watanabe, Megumi, et al.
Publicado: (2022)

All-trans Retinoic Acids Synergistically and Beneficially Affect In Vitro Glaucomatous Trabecular Meshwork (TM) Models Using 2D and 3D Cell Cultures of Human TM Cells
por: Watanabe, Megumi, et al.
Publicado: (2022)

FGF-2 enhances fibrogenetic changes in TGF-β2 treated human conjunctival fibroblasts
por: Tsugeno, Yuri, et al.
Publicado: (2022)

Comparison of the Drug-Induced Efficacies between Omidenepag Isopropyl, an EP2 Agonist and PGF2α toward TGF-β2-Modulated Human Trabecular Meshwork (HTM) Cells
por: Suzuki, Soma, et al.
Publicado: (2022)

Human Trabecular Meshwork (HTM) Cells Treated with TGF-β2 or Dexamethasone Respond to Compression Stress in Different Manners
por: Watanabe, Megumi, et al.
Publicado: (2022)

Brimonidine Modulates the ROCK1 Signaling Effects on Adipogenic Differentiation in 2D and 3D 3T3-L1 Cells
por: Umetsu, Araya, et al.
Publicado: (2022)

ROCK 1 and 2 affect the spatial architecture of 3D spheroids derived from human corneal stromal fibroblasts in different manners
por: Ida, Yosuke, et al.
Publicado: (2022)

Fatty Acid-Binding Proteins 4 and 5 Are Involved in the Pathogenesis of Retinal Vascular Diseases in Different Manners
por: Higashide, Megumi, et al.
Publicado: (2022)

Pan-ROCK and ROCK2 Inhibitors Affect Dexamethasone-Treated 2D- and 3D-Cultured Human Trabecular Meshwork (HTM) Cells in Opposite Manners
por: Watanabe, Megumi, et al.
Publicado: (2021)

Prostaglandin F2 and EP2 Agonists Exert Different Effects on 3D 3T3-L1 Spheroids during Their Culture Phase
por: Ida, Yosuke, et al.
Publicado: (2021)

Benzalkonium Chloride, Even at Low Concentrations, Deteriorates Intracellular Metabolic Capacity in Human Conjunctival Fibroblasts
por: Tsugeno, Yuri, et al.
Publicado: (2022)

The Selective α1 Antagonist Tamsulosin Alters ECM Distributions and Cellular Metabolic Functions of ARPE 19 Cells in a Concentration-Dependent Manner
por: Ida, Yosuke, et al.
Publicado: (2022)

Screening of the Drug-Induced Effects of Prostaglandin EP2 and FP Agonists on 3D Cultures of Dexamethasone-Treated Human Trabecular Meshwork Cells
por: Watanabe, Megumi, et al.
Publicado: (2021)

Reactivities of a Prostanoid EP2 Agonist, Omidenepag, Are Useful for Distinguishing between 3D Spheroids of Human Orbital Fibroblasts without or with Graves’ Orbitopathy
por: Ida, Yosuke, et al.
Publicado: (2021)

Autotaxin May Have Lysophosphatidic Acid-Unrelated Effects on Three-Dimension (3D) Cultured Human Trabecular Meshwork (HTM) Cells
por: Watanabe, Megumi, et al.
Publicado: (2021)

TGF-β2 Induces Epithelial–Mesenchymal Transitions in 2D Planer and 3D Spheroids of the Human Corneal Stroma Fibroblasts in Different Manners
por: Umetsu, Araya, et al.
Publicado: (2023)

STAT3 Is the Master Regulator for the Forming of 3D Spheroids of 3T3-L1 Preadipocytes
por: Ohguro, Hiroshi, et al.
Publicado: (2022)

3D culture induction of adipogenic differentiation in 3T3-L1 preadipocytes exhibits adipocyte-specific molecular expression patterns and metabolic functions
por: Endo, Keisuke, et al.
Publicado: (2023)

Modulation of the Physical Properties of 3D Spheroids Derived from Human Scleral Stroma Fibroblasts (HSSFs) with Different Axial Lengths Obtained from Surgical Patients
por: Katayama, Hiroyasu, et al.
Publicado: (2021)

TGF-β-3 Induces Different Effects from TGF-β-1 and -2 on Cellular Metabolism and the Spatial Properties of the Human Trabecular Meshwork Cells
por: Watanabe, Megumi, et al.
Publicado: (2023)

Addition of ROCK Inhibitors Alleviates Prostaglandin-Induced Inhibition of Adipogenesis in 3T3L-1 Spheroids
por: Ida, Yosuke, et al.
Publicado: (2022)

mTOR Inhibitors Modulate the Physical Properties of 3D Spheroids Derived from H9c2 Cells
por: Watanabe, Megumi, et al.
Publicado: (2023)

Diverse effects of pan-ROCK and ROCK2 inhibitors on 2 D and 3D cultured human trabecular meshwork (HTM) cells treated with TGFβ2
por: Watanabe, Megumi, et al.
Publicado: (2021)

ROCK inhibitors modulate the physical properties and adipogenesis of 3D spheroids of human orbital fibroblasts in different manners
por: Hikage, Fumihito, et al.
Publicado: (2021)

TGF-β Isoforms Affect the Planar and Subepithelial Fibrogenesis of Human Conjunctival Fibroblasts in Different Manners
por: Watanabe, Megumi, et al.
Publicado: (2023)

Unexpected Crosslinking Effects of a Human Thyroid Stimulating Monoclonal Autoantibody, M22, with IGF1 on Adipogenesis in 3T3L-1 Cells
por: Umetsu, Araya, et al.
Publicado: (2023)

Establishment of appropriate glaucoma models using dexamethasone or TGFβ2 treated three-dimension (3D) cultured human trabecular meshwork (HTM) cells
por: Watanabe, Megumi, et al.
Publicado: (2021)

Omidenepag, a non-prostanoid EP2 receptor agonist, induces enlargement of the 3D organoid of 3T3-L1 cells
por: Ida, Yosuke, et al.
Publicado: (2020)

Detection of significantly high vitreous concentrations of fatty acid-binding protein 4 in patients with proliferative diabetic retinopathy
por: Itoh, Kaku, et al.
Publicado: (2021)

Fatty acid-binding protein 4 is an independent factor in the pathogenesis of retinal vein occlusion
por: Hikage, Fumihito, et al.
Publicado: (2021)

Rosiglitasone and ROCK Inhibitors Modulate Fibrogenetic Changes in TGF-β2 Treated Human Conjunctival Fibroblasts (HconF) in Different Manners
por: Oouchi, Yuika, et al.
Publicado: (2021)

Omidenepag, a Selective, Prostanoid EP2 Agonist, Does Not Suppress Adipogenesis in 3D Organoids of Human Orbital Fibroblasts
por: Hikage, Fumihito, et al.
Publicado: (2021)

Three-Dimensional Spheroid Configurations and Cellular Metabolic Properties of Oral Squamous Carcinomas Are Possible Pharmacological and Pathological Indicators
por: Miyamoto, Sho, et al.
Publicado: (2023)

3D Spheroid Configurations Are Possible Indictors for Evaluating the Pathophysiology of Melanoma Cell Lines
por: Ohguro, Hiroshi, et al.
Publicado: (2023)

ROCK inhibitors beneficially alter the spatial configuration of TGFβ2-treated 3D organoids from a human trabecular meshwork (HTM)
por: Ota, Chiaki, et al.
Publicado: (2020)

Simultaneous Use of ROCK Inhibitors and EP2 Agonists Induces Unexpected Effects on Adipogenesis and the Physical Properties of 3T3-L1 Preadipocytes
por: Ida, Yosuke, et al.
Publicado: (2021)

G-Protein-Coupled Receptors Mediate Modulations of Cell Viability and Drug Sensitivity by Aberrantly Expressed Recoverin 3 within A549 Cells
por: Ichioka, Hanae, et al.
Publicado: (2023)

Prostaglandin F2α Agonists Negatively Modulate the Size of 3D Organoids from Primary Human Orbital Fibroblasts
por: Itoh, Kaku, et al.
Publicado: (2020)

ROCK inhibitors enhance the production of large lipid-enriched 3D organoids of 3T3-L1 cells
por: Ida, Yosuke, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_akq97j7iukuvhc4r28f76sspkg