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Reduced Environmental Dose Rates Are Responsible for the Increased Susceptibility to Radiation-Induced DNA Damage in Larval Neuroblasts of Drosophila Grown inside the LNGS Underground Laboratory

A large amount of evidence from radiobiology studies carried out in Deep Underground Laboratories support the view that environmental radiation may trigger biological mechanisms that enable both simple and complex organisms to cope with genotoxic stress. In line with this, here we show that the redu...

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Autores principales: Porrazzo, Antonella, Esposito, Giuseppe, Grifoni, Daniela, Cenci, Giovanni, Morciano, Patrizia, Tabocchini, Maria Antonella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143493/
https://www.ncbi.nlm.nih.gov/pubmed/35628279
http://dx.doi.org/10.3390/ijms23105472
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author Porrazzo, Antonella
Esposito, Giuseppe
Grifoni, Daniela
Cenci, Giovanni
Morciano, Patrizia
Tabocchini, Maria Antonella
author_facet Porrazzo, Antonella
Esposito, Giuseppe
Grifoni, Daniela
Cenci, Giovanni
Morciano, Patrizia
Tabocchini, Maria Antonella
author_sort Porrazzo, Antonella
collection PubMed
description A large amount of evidence from radiobiology studies carried out in Deep Underground Laboratories support the view that environmental radiation may trigger biological mechanisms that enable both simple and complex organisms to cope with genotoxic stress. In line with this, here we show that the reduced radiation background of the LNGS underground laboratory renders Drosophila neuroblasts more sensitive to ionizing radiation-induced (but not to spontaneous) DNA breaks compared to fruit flies kept at the external reference laboratory. Interestingly, we demonstrate that the ionizing radiation sensitivity of flies kept at the LNGS underground laboratory is rescued by increasing the underground gamma dose rate to levels comparable to the low-LET reference one. This finding provides the first direct evidence that the modulation of the DNA damage response in a complex multicellular organism is indeed dependent on the environmental dose rate.
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spelling pubmed-91434932022-05-29 Reduced Environmental Dose Rates Are Responsible for the Increased Susceptibility to Radiation-Induced DNA Damage in Larval Neuroblasts of Drosophila Grown inside the LNGS Underground Laboratory Porrazzo, Antonella Esposito, Giuseppe Grifoni, Daniela Cenci, Giovanni Morciano, Patrizia Tabocchini, Maria Antonella Int J Mol Sci Communication A large amount of evidence from radiobiology studies carried out in Deep Underground Laboratories support the view that environmental radiation may trigger biological mechanisms that enable both simple and complex organisms to cope with genotoxic stress. In line with this, here we show that the reduced radiation background of the LNGS underground laboratory renders Drosophila neuroblasts more sensitive to ionizing radiation-induced (but not to spontaneous) DNA breaks compared to fruit flies kept at the external reference laboratory. Interestingly, we demonstrate that the ionizing radiation sensitivity of flies kept at the LNGS underground laboratory is rescued by increasing the underground gamma dose rate to levels comparable to the low-LET reference one. This finding provides the first direct evidence that the modulation of the DNA damage response in a complex multicellular organism is indeed dependent on the environmental dose rate. MDPI 2022-05-13 /pmc/articles/PMC9143493/ /pubmed/35628279 http://dx.doi.org/10.3390/ijms23105472 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Porrazzo, Antonella
Esposito, Giuseppe
Grifoni, Daniela
Cenci, Giovanni
Morciano, Patrizia
Tabocchini, Maria Antonella
Reduced Environmental Dose Rates Are Responsible for the Increased Susceptibility to Radiation-Induced DNA Damage in Larval Neuroblasts of Drosophila Grown inside the LNGS Underground Laboratory
title Reduced Environmental Dose Rates Are Responsible for the Increased Susceptibility to Radiation-Induced DNA Damage in Larval Neuroblasts of Drosophila Grown inside the LNGS Underground Laboratory
title_full Reduced Environmental Dose Rates Are Responsible for the Increased Susceptibility to Radiation-Induced DNA Damage in Larval Neuroblasts of Drosophila Grown inside the LNGS Underground Laboratory
title_fullStr Reduced Environmental Dose Rates Are Responsible for the Increased Susceptibility to Radiation-Induced DNA Damage in Larval Neuroblasts of Drosophila Grown inside the LNGS Underground Laboratory
title_full_unstemmed Reduced Environmental Dose Rates Are Responsible for the Increased Susceptibility to Radiation-Induced DNA Damage in Larval Neuroblasts of Drosophila Grown inside the LNGS Underground Laboratory
title_short Reduced Environmental Dose Rates Are Responsible for the Increased Susceptibility to Radiation-Induced DNA Damage in Larval Neuroblasts of Drosophila Grown inside the LNGS Underground Laboratory
title_sort reduced environmental dose rates are responsible for the increased susceptibility to radiation-induced dna damage in larval neuroblasts of drosophila grown inside the lngs underground laboratory
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143493/
https://www.ncbi.nlm.nih.gov/pubmed/35628279
http://dx.doi.org/10.3390/ijms23105472
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