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Anticholinergic Load Is Associated with Swallowing Dysfunction in Convalescent Older Patients after a Stroke
This study aimed to establish whether anticholinergic load affects the swallowing function of geriatric stroke patients in convalescent stages, as no proven association between the anticholinergic load-based Anticholinergic Risk Scale and the swallowing dysfunction in Japanese patients was known. A...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143519/ https://www.ncbi.nlm.nih.gov/pubmed/35631262 http://dx.doi.org/10.3390/nu14102121 |
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author | Kose, Eiji Hirai, Toshiyuki Seki, Toshiichi Okudaira, Michiyo Yasuno, Nobuhiro |
author_facet | Kose, Eiji Hirai, Toshiyuki Seki, Toshiichi Okudaira, Michiyo Yasuno, Nobuhiro |
author_sort | Kose, Eiji |
collection | PubMed |
description | This study aimed to establish whether anticholinergic load affects the swallowing function of geriatric stroke patients in convalescent stages, as no proven association between the anticholinergic load-based Anticholinergic Risk Scale and the swallowing dysfunction in Japanese patients was known. A retrospective cohort study was conducted on hospitalized older patients undergoing rehabilitation after stroke. The study outcomes included evaluating the patients at hospital discharge using the Functional Oral Intake Scale. To evaluate the effects of an increased anticholinergic load, we used a multivariate analysis to examine whether the change in the Anticholinergic Risk Scale during hospitalization was associated with the outcome. Of 542 enrolled patients, 345 (63.7%) presented with cerebral infarction, 148 (27.3%) with intracerebral hemorrhage, and 49 (9%) with subarachnoid hemorrhage. The change in the Anticholinergic Risk Scale was independently associated with the Functional Oral Intake Scale (β = −0.118, p = 0.0164) at discharge. Among anticholinergics, the use of chlorpromazine, hydroxyzine, haloperidol, metoclopramide, risperidone, etc., increased significantly from admission to discharge. An increased anticholinergic load was associated with swallowing dysfunction in older patients undergoing stroke rehabilitation. |
format | Online Article Text |
id | pubmed-9143519 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91435192022-05-29 Anticholinergic Load Is Associated with Swallowing Dysfunction in Convalescent Older Patients after a Stroke Kose, Eiji Hirai, Toshiyuki Seki, Toshiichi Okudaira, Michiyo Yasuno, Nobuhiro Nutrients Article This study aimed to establish whether anticholinergic load affects the swallowing function of geriatric stroke patients in convalescent stages, as no proven association between the anticholinergic load-based Anticholinergic Risk Scale and the swallowing dysfunction in Japanese patients was known. A retrospective cohort study was conducted on hospitalized older patients undergoing rehabilitation after stroke. The study outcomes included evaluating the patients at hospital discharge using the Functional Oral Intake Scale. To evaluate the effects of an increased anticholinergic load, we used a multivariate analysis to examine whether the change in the Anticholinergic Risk Scale during hospitalization was associated with the outcome. Of 542 enrolled patients, 345 (63.7%) presented with cerebral infarction, 148 (27.3%) with intracerebral hemorrhage, and 49 (9%) with subarachnoid hemorrhage. The change in the Anticholinergic Risk Scale was independently associated with the Functional Oral Intake Scale (β = −0.118, p = 0.0164) at discharge. Among anticholinergics, the use of chlorpromazine, hydroxyzine, haloperidol, metoclopramide, risperidone, etc., increased significantly from admission to discharge. An increased anticholinergic load was associated with swallowing dysfunction in older patients undergoing stroke rehabilitation. MDPI 2022-05-19 /pmc/articles/PMC9143519/ /pubmed/35631262 http://dx.doi.org/10.3390/nu14102121 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kose, Eiji Hirai, Toshiyuki Seki, Toshiichi Okudaira, Michiyo Yasuno, Nobuhiro Anticholinergic Load Is Associated with Swallowing Dysfunction in Convalescent Older Patients after a Stroke |
title | Anticholinergic Load Is Associated with Swallowing Dysfunction in Convalescent Older Patients after a Stroke |
title_full | Anticholinergic Load Is Associated with Swallowing Dysfunction in Convalescent Older Patients after a Stroke |
title_fullStr | Anticholinergic Load Is Associated with Swallowing Dysfunction in Convalescent Older Patients after a Stroke |
title_full_unstemmed | Anticholinergic Load Is Associated with Swallowing Dysfunction in Convalescent Older Patients after a Stroke |
title_short | Anticholinergic Load Is Associated with Swallowing Dysfunction in Convalescent Older Patients after a Stroke |
title_sort | anticholinergic load is associated with swallowing dysfunction in convalescent older patients after a stroke |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143519/ https://www.ncbi.nlm.nih.gov/pubmed/35631262 http://dx.doi.org/10.3390/nu14102121 |
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