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Anticholinergic Load Is Associated with Swallowing Dysfunction in Convalescent Older Patients after a Stroke

This study aimed to establish whether anticholinergic load affects the swallowing function of geriatric stroke patients in convalescent stages, as no proven association between the anticholinergic load-based Anticholinergic Risk Scale and the swallowing dysfunction in Japanese patients was known. A...

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Autores principales: Kose, Eiji, Hirai, Toshiyuki, Seki, Toshiichi, Okudaira, Michiyo, Yasuno, Nobuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143519/
https://www.ncbi.nlm.nih.gov/pubmed/35631262
http://dx.doi.org/10.3390/nu14102121
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author Kose, Eiji
Hirai, Toshiyuki
Seki, Toshiichi
Okudaira, Michiyo
Yasuno, Nobuhiro
author_facet Kose, Eiji
Hirai, Toshiyuki
Seki, Toshiichi
Okudaira, Michiyo
Yasuno, Nobuhiro
author_sort Kose, Eiji
collection PubMed
description This study aimed to establish whether anticholinergic load affects the swallowing function of geriatric stroke patients in convalescent stages, as no proven association between the anticholinergic load-based Anticholinergic Risk Scale and the swallowing dysfunction in Japanese patients was known. A retrospective cohort study was conducted on hospitalized older patients undergoing rehabilitation after stroke. The study outcomes included evaluating the patients at hospital discharge using the Functional Oral Intake Scale. To evaluate the effects of an increased anticholinergic load, we used a multivariate analysis to examine whether the change in the Anticholinergic Risk Scale during hospitalization was associated with the outcome. Of 542 enrolled patients, 345 (63.7%) presented with cerebral infarction, 148 (27.3%) with intracerebral hemorrhage, and 49 (9%) with subarachnoid hemorrhage. The change in the Anticholinergic Risk Scale was independently associated with the Functional Oral Intake Scale (β = −0.118, p = 0.0164) at discharge. Among anticholinergics, the use of chlorpromazine, hydroxyzine, haloperidol, metoclopramide, risperidone, etc., increased significantly from admission to discharge. An increased anticholinergic load was associated with swallowing dysfunction in older patients undergoing stroke rehabilitation.
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spelling pubmed-91435192022-05-29 Anticholinergic Load Is Associated with Swallowing Dysfunction in Convalescent Older Patients after a Stroke Kose, Eiji Hirai, Toshiyuki Seki, Toshiichi Okudaira, Michiyo Yasuno, Nobuhiro Nutrients Article This study aimed to establish whether anticholinergic load affects the swallowing function of geriatric stroke patients in convalescent stages, as no proven association between the anticholinergic load-based Anticholinergic Risk Scale and the swallowing dysfunction in Japanese patients was known. A retrospective cohort study was conducted on hospitalized older patients undergoing rehabilitation after stroke. The study outcomes included evaluating the patients at hospital discharge using the Functional Oral Intake Scale. To evaluate the effects of an increased anticholinergic load, we used a multivariate analysis to examine whether the change in the Anticholinergic Risk Scale during hospitalization was associated with the outcome. Of 542 enrolled patients, 345 (63.7%) presented with cerebral infarction, 148 (27.3%) with intracerebral hemorrhage, and 49 (9%) with subarachnoid hemorrhage. The change in the Anticholinergic Risk Scale was independently associated with the Functional Oral Intake Scale (β = −0.118, p = 0.0164) at discharge. Among anticholinergics, the use of chlorpromazine, hydroxyzine, haloperidol, metoclopramide, risperidone, etc., increased significantly from admission to discharge. An increased anticholinergic load was associated with swallowing dysfunction in older patients undergoing stroke rehabilitation. MDPI 2022-05-19 /pmc/articles/PMC9143519/ /pubmed/35631262 http://dx.doi.org/10.3390/nu14102121 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kose, Eiji
Hirai, Toshiyuki
Seki, Toshiichi
Okudaira, Michiyo
Yasuno, Nobuhiro
Anticholinergic Load Is Associated with Swallowing Dysfunction in Convalescent Older Patients after a Stroke
title Anticholinergic Load Is Associated with Swallowing Dysfunction in Convalescent Older Patients after a Stroke
title_full Anticholinergic Load Is Associated with Swallowing Dysfunction in Convalescent Older Patients after a Stroke
title_fullStr Anticholinergic Load Is Associated with Swallowing Dysfunction in Convalescent Older Patients after a Stroke
title_full_unstemmed Anticholinergic Load Is Associated with Swallowing Dysfunction in Convalescent Older Patients after a Stroke
title_short Anticholinergic Load Is Associated with Swallowing Dysfunction in Convalescent Older Patients after a Stroke
title_sort anticholinergic load is associated with swallowing dysfunction in convalescent older patients after a stroke
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143519/
https://www.ncbi.nlm.nih.gov/pubmed/35631262
http://dx.doi.org/10.3390/nu14102121
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