The Amyotrophic Lateral Sclerosis M114T PFN1 Mutation Deregulates Alternative Autophagy Pathways and Mitochondrial Homeostasis

Mutations in profilin 1 (PFN1) have been identified in rare familial cases of Amyotrophic Lateral Sclerosis (ALS). PFN1 is involved in multiple pathways that could intervene in ALS pathology. However, the specific pathogenic role of PFN1 mutations in ALS is still not fully understood. We hypothesize...

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Detalles Bibliográficos
Autores principales: Teyssou, Elisa, Chartier, Laura, Roussel, Delphine, Perera, Nirma D., Nemazanyy, Ivan, Langui, Dominique, Albert, Mélanie, Larmonier, Thierry, Saker, Safaa, Salachas, François, Pradat, Pierre-François, Meininger, Vincent, Ravassard, Philippe, Côté, Francine, Lobsiger, Christian S., Boillée, Séverine, Turner, Bradley J., Seilhean, Danielle, Millecamps, Stéphanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143529/
https://www.ncbi.nlm.nih.gov/pubmed/35628504
http://dx.doi.org/10.3390/ijms23105694

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