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Hydrophilic CO-Releasing Material of PEGlyated Ruthenium Carbonyl Complex
The poor water-solubility and instability of Ru(II) carbonyl complex hamper the therapeutic application as CO releasing materials (CO-RMs). To enhance the hydrophilicity and bio-utility of CO, a robust Ru(I) carbonyl sawhorse skeleton was grafted with water-soluble PEGylated sidearm. In this case, 1...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143562/ https://www.ncbi.nlm.nih.gov/pubmed/35629627 http://dx.doi.org/10.3390/ma15103597 |
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author | Zhang, Xiao Guo, Nan Yang, Shuhong Khan, Huma Zhang, Weiqiang |
author_facet | Zhang, Xiao Guo, Nan Yang, Shuhong Khan, Huma Zhang, Weiqiang |
author_sort | Zhang, Xiao |
collection | PubMed |
description | The poor water-solubility and instability of Ru(II) carbonyl complex hamper the therapeutic application as CO releasing materials (CO-RMs). To enhance the hydrophilicity and bio-utility of CO, a robust Ru(I) carbonyl sawhorse skeleton was grafted with water-soluble PEGylated sidearm. In this case, 12 PEGylated sawhorse Ru(2)(CO)(4) complexes were prepared with satisfactory yields and characterized by IR and (1)H- and (13)C- NMR. X-ray diffraction analysis of CO-RM 8, 13 and 14 revealed the featured diruthenium sawhorse skeleton and PEGylated axial ligands. The flask-shaking method measures the water-solubility of CO-RMs, indicating that both bridging carboxylate ligands and PEGlyated axial ligands regulate the hydrophilicity of these CO-RMs. Under photolysis conditions, CO-RM 4–13 sustainable released therapeutic amounts of CO in the myoglobin assay. The correlation of the CO release kinetics and hydrophilicity of CO-RMs demonstrated that the more hydrophilic CO-RM released CO faster. The biological test found that the low cytotoxic CO-RM 4 showed a specific anticancer activity toward HT-29 tumour cells. |
format | Online Article Text |
id | pubmed-9143562 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91435622022-05-29 Hydrophilic CO-Releasing Material of PEGlyated Ruthenium Carbonyl Complex Zhang, Xiao Guo, Nan Yang, Shuhong Khan, Huma Zhang, Weiqiang Materials (Basel) Article The poor water-solubility and instability of Ru(II) carbonyl complex hamper the therapeutic application as CO releasing materials (CO-RMs). To enhance the hydrophilicity and bio-utility of CO, a robust Ru(I) carbonyl sawhorse skeleton was grafted with water-soluble PEGylated sidearm. In this case, 12 PEGylated sawhorse Ru(2)(CO)(4) complexes were prepared with satisfactory yields and characterized by IR and (1)H- and (13)C- NMR. X-ray diffraction analysis of CO-RM 8, 13 and 14 revealed the featured diruthenium sawhorse skeleton and PEGylated axial ligands. The flask-shaking method measures the water-solubility of CO-RMs, indicating that both bridging carboxylate ligands and PEGlyated axial ligands regulate the hydrophilicity of these CO-RMs. Under photolysis conditions, CO-RM 4–13 sustainable released therapeutic amounts of CO in the myoglobin assay. The correlation of the CO release kinetics and hydrophilicity of CO-RMs demonstrated that the more hydrophilic CO-RM released CO faster. The biological test found that the low cytotoxic CO-RM 4 showed a specific anticancer activity toward HT-29 tumour cells. MDPI 2022-05-18 /pmc/articles/PMC9143562/ /pubmed/35629627 http://dx.doi.org/10.3390/ma15103597 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zhang, Xiao Guo, Nan Yang, Shuhong Khan, Huma Zhang, Weiqiang Hydrophilic CO-Releasing Material of PEGlyated Ruthenium Carbonyl Complex |
title | Hydrophilic CO-Releasing Material of PEGlyated Ruthenium Carbonyl Complex |
title_full | Hydrophilic CO-Releasing Material of PEGlyated Ruthenium Carbonyl Complex |
title_fullStr | Hydrophilic CO-Releasing Material of PEGlyated Ruthenium Carbonyl Complex |
title_full_unstemmed | Hydrophilic CO-Releasing Material of PEGlyated Ruthenium Carbonyl Complex |
title_short | Hydrophilic CO-Releasing Material of PEGlyated Ruthenium Carbonyl Complex |
title_sort | hydrophilic co-releasing material of peglyated ruthenium carbonyl complex |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143562/ https://www.ncbi.nlm.nih.gov/pubmed/35629627 http://dx.doi.org/10.3390/ma15103597 |
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