Cytochalasans from the Endophytic Fungus Phomopsis sp. shj2 and Their Antimigratory Activities

Cytochalasans from the endophytic fungi featured structure diversity. Our previous study has disclosed that cytochalasans from the endophytic fungus Phomopsis sp. shj2 exhibited an antimigratory effect. Further chemical investigation on Phomopsis sp. shj2 has led to the discovery of seven new cytoch...

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Autores principales: Yan, Bing-Chao, Wang, Wei-Guang, Kong, Ling-Mei, Tang, Jian-Wei, Du, Xue, Li, Yan, Puno, Pema-Tenzin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143583/
https://www.ncbi.nlm.nih.gov/pubmed/35628798
http://dx.doi.org/10.3390/jof8050543
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author Yan, Bing-Chao
Wang, Wei-Guang
Kong, Ling-Mei
Tang, Jian-Wei
Du, Xue
Li, Yan
Puno, Pema-Tenzin
author_facet Yan, Bing-Chao
Wang, Wei-Guang
Kong, Ling-Mei
Tang, Jian-Wei
Du, Xue
Li, Yan
Puno, Pema-Tenzin
author_sort Yan, Bing-Chao
collection PubMed
description Cytochalasans from the endophytic fungi featured structure diversity. Our previous study has disclosed that cytochalasans from the endophytic fungus Phomopsis sp. shj2 exhibited an antimigratory effect. Further chemical investigation on Phomopsis sp. shj2 has led to the discovery of seven new cytochalasans (1–7), together with four known ones. Their structures were elucidated through extensive spectroscopic data interpretation and single-crystal X-ray diffraction analysis. Compounds 1–3 and 8–11 exhibited antimigratory effects against MDA-MB-231 in vitro with IC(50) values in the range of 1.01−10.42 μM.
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spelling pubmed-91435832022-05-29 Cytochalasans from the Endophytic Fungus Phomopsis sp. shj2 and Their Antimigratory Activities Yan, Bing-Chao Wang, Wei-Guang Kong, Ling-Mei Tang, Jian-Wei Du, Xue Li, Yan Puno, Pema-Tenzin J Fungi (Basel) Article Cytochalasans from the endophytic fungi featured structure diversity. Our previous study has disclosed that cytochalasans from the endophytic fungus Phomopsis sp. shj2 exhibited an antimigratory effect. Further chemical investigation on Phomopsis sp. shj2 has led to the discovery of seven new cytochalasans (1–7), together with four known ones. Their structures were elucidated through extensive spectroscopic data interpretation and single-crystal X-ray diffraction analysis. Compounds 1–3 and 8–11 exhibited antimigratory effects against MDA-MB-231 in vitro with IC(50) values in the range of 1.01−10.42 μM. MDPI 2022-05-23 /pmc/articles/PMC9143583/ /pubmed/35628798 http://dx.doi.org/10.3390/jof8050543 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yan, Bing-Chao
Wang, Wei-Guang
Kong, Ling-Mei
Tang, Jian-Wei
Du, Xue
Li, Yan
Puno, Pema-Tenzin
Cytochalasans from the Endophytic Fungus Phomopsis sp. shj2 and Their Antimigratory Activities
title Cytochalasans from the Endophytic Fungus Phomopsis sp. shj2 and Their Antimigratory Activities
title_full Cytochalasans from the Endophytic Fungus Phomopsis sp. shj2 and Their Antimigratory Activities
title_fullStr Cytochalasans from the Endophytic Fungus Phomopsis sp. shj2 and Their Antimigratory Activities
title_full_unstemmed Cytochalasans from the Endophytic Fungus Phomopsis sp. shj2 and Their Antimigratory Activities
title_short Cytochalasans from the Endophytic Fungus Phomopsis sp. shj2 and Their Antimigratory Activities
title_sort cytochalasans from the endophytic fungus phomopsis sp. shj2 and their antimigratory activities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143583/
https://www.ncbi.nlm.nih.gov/pubmed/35628798
http://dx.doi.org/10.3390/jof8050543
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