Cargando…

Nosocomial COVID-19 Infection in a Long-Term Hospital in Spain: Retrospective Observational Study

Background and Objectives. The aim of this study is to compare clinical and epidemiological characteristics and outcomes in patients with versus without nosocomial COVID-19 after exposure to SARS-CoV-2 and to analyze the risk factors for severe outcomes of COVID-19 in a long-term hospital in Spain....

Descripción completa

Detalles Bibliográficos
Autores principales: Caro-Martínez, Elena, Abad-Collado, Susana, Escrivá-Cerrudo, Blanca, García-Almarza, Shaila, García-Ródenas, María del Mar, Gómez-Merino, Elena, Serrano-Mateo, María-Isabel, Ramos-Rincón, Jose-Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143631/
https://www.ncbi.nlm.nih.gov/pubmed/35629983
http://dx.doi.org/10.3390/medicina58050566
_version_ 1784715853492649984
author Caro-Martínez, Elena
Abad-Collado, Susana
Escrivá-Cerrudo, Blanca
García-Almarza, Shaila
García-Ródenas, María del Mar
Gómez-Merino, Elena
Serrano-Mateo, María-Isabel
Ramos-Rincón, Jose-Manuel
author_facet Caro-Martínez, Elena
Abad-Collado, Susana
Escrivá-Cerrudo, Blanca
García-Almarza, Shaila
García-Ródenas, María del Mar
Gómez-Merino, Elena
Serrano-Mateo, María-Isabel
Ramos-Rincón, Jose-Manuel
author_sort Caro-Martínez, Elena
collection PubMed
description Background and Objectives. The aim of this study is to compare clinical and epidemiological characteristics and outcomes in patients with versus without nosocomial COVID-19 after exposure to SARS-CoV-2 and to analyze the risk factors for severe outcomes of COVID-19 in a long-term hospital in Spain. Materials and methods. This retrospective, single-center observational study included all inpatients in a long-term hospital during a COVID-19 outbreak from 21 January to 15 March 2021. Results. Of 108 admitted patients, 65 (60.2%) were diagnosed with nosocomial COVID-19 disease (n = 34 women (52.3%), median age 77 years). In the univariable analysis, risk factors associated with nosocomial COVID-19 were dementia (OR 4.98 95% CI 1.58–15.75), dyspnea (OR 5.34 95% CI 1.69–16.82), asthenia (OR 5.10, 95% CI 1.40–18.60) and NECesidades PALiativas (NECPAL) (OR 1.28 95% CI 1.10–1.48). In the multivariable analysis, risk factors independently associated with nosocomial COVID-19 infection were dyspnea (aOR 7.39; 95% CI 1.27–43.11) and NECPAL (aOR 1.25; 95% CI 1.03–1.52). Of the 65 patients diagnosed with nosocomial COVID-19, 29 (44.6%) died, compared to 7/43 (16.2%) non-infected patients (OR 4.14, 95% CI 1.61–10.67). Factors associated with mortality in nosocomial COVID-19 were confusion (aOR 3.83; 95% CI 1.03–14.27) and dyspnea (aOR 7.47; 95% CI 1.87–29.82). The NECPAL tool played an important predictive role in both nosocomial COVID-19 infection and mortality (aOR 1.19, 95% CI: 1.00–1.41). Conclusions. In a long-term hospital, nosocomial COVID-19 main clinical characteristics associated with infection were dyspnea and NECPAL. Mortality was higher in the group with nosocomial COVID-19; risk factors were confusion and dyspnea. The NECPAL tool may help to predict progression and death in COVID-19.
format Online
Article
Text
id pubmed-9143631
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-91436312022-05-29 Nosocomial COVID-19 Infection in a Long-Term Hospital in Spain: Retrospective Observational Study Caro-Martínez, Elena Abad-Collado, Susana Escrivá-Cerrudo, Blanca García-Almarza, Shaila García-Ródenas, María del Mar Gómez-Merino, Elena Serrano-Mateo, María-Isabel Ramos-Rincón, Jose-Manuel Medicina (Kaunas) Article Background and Objectives. The aim of this study is to compare clinical and epidemiological characteristics and outcomes in patients with versus without nosocomial COVID-19 after exposure to SARS-CoV-2 and to analyze the risk factors for severe outcomes of COVID-19 in a long-term hospital in Spain. Materials and methods. This retrospective, single-center observational study included all inpatients in a long-term hospital during a COVID-19 outbreak from 21 January to 15 March 2021. Results. Of 108 admitted patients, 65 (60.2%) were diagnosed with nosocomial COVID-19 disease (n = 34 women (52.3%), median age 77 years). In the univariable analysis, risk factors associated with nosocomial COVID-19 were dementia (OR 4.98 95% CI 1.58–15.75), dyspnea (OR 5.34 95% CI 1.69–16.82), asthenia (OR 5.10, 95% CI 1.40–18.60) and NECesidades PALiativas (NECPAL) (OR 1.28 95% CI 1.10–1.48). In the multivariable analysis, risk factors independently associated with nosocomial COVID-19 infection were dyspnea (aOR 7.39; 95% CI 1.27–43.11) and NECPAL (aOR 1.25; 95% CI 1.03–1.52). Of the 65 patients diagnosed with nosocomial COVID-19, 29 (44.6%) died, compared to 7/43 (16.2%) non-infected patients (OR 4.14, 95% CI 1.61–10.67). Factors associated with mortality in nosocomial COVID-19 were confusion (aOR 3.83; 95% CI 1.03–14.27) and dyspnea (aOR 7.47; 95% CI 1.87–29.82). The NECPAL tool played an important predictive role in both nosocomial COVID-19 infection and mortality (aOR 1.19, 95% CI: 1.00–1.41). Conclusions. In a long-term hospital, nosocomial COVID-19 main clinical characteristics associated with infection were dyspnea and NECPAL. Mortality was higher in the group with nosocomial COVID-19; risk factors were confusion and dyspnea. The NECPAL tool may help to predict progression and death in COVID-19. MDPI 2022-04-21 /pmc/articles/PMC9143631/ /pubmed/35629983 http://dx.doi.org/10.3390/medicina58050566 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Caro-Martínez, Elena
Abad-Collado, Susana
Escrivá-Cerrudo, Blanca
García-Almarza, Shaila
García-Ródenas, María del Mar
Gómez-Merino, Elena
Serrano-Mateo, María-Isabel
Ramos-Rincón, Jose-Manuel
Nosocomial COVID-19 Infection in a Long-Term Hospital in Spain: Retrospective Observational Study
title Nosocomial COVID-19 Infection in a Long-Term Hospital in Spain: Retrospective Observational Study
title_full Nosocomial COVID-19 Infection in a Long-Term Hospital in Spain: Retrospective Observational Study
title_fullStr Nosocomial COVID-19 Infection in a Long-Term Hospital in Spain: Retrospective Observational Study
title_full_unstemmed Nosocomial COVID-19 Infection in a Long-Term Hospital in Spain: Retrospective Observational Study
title_short Nosocomial COVID-19 Infection in a Long-Term Hospital in Spain: Retrospective Observational Study
title_sort nosocomial covid-19 infection in a long-term hospital in spain: retrospective observational study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143631/
https://www.ncbi.nlm.nih.gov/pubmed/35629983
http://dx.doi.org/10.3390/medicina58050566
work_keys_str_mv AT caromartinezelena nosocomialcovid19infectioninalongtermhospitalinspainretrospectiveobservationalstudy
AT abadcolladosusana nosocomialcovid19infectioninalongtermhospitalinspainretrospectiveobservationalstudy
AT escrivacerrudoblanca nosocomialcovid19infectioninalongtermhospitalinspainretrospectiveobservationalstudy
AT garciaalmarzashaila nosocomialcovid19infectioninalongtermhospitalinspainretrospectiveobservationalstudy
AT garciarodenasmariadelmar nosocomialcovid19infectioninalongtermhospitalinspainretrospectiveobservationalstudy
AT gomezmerinoelena nosocomialcovid19infectioninalongtermhospitalinspainretrospectiveobservationalstudy
AT serranomateomariaisabel nosocomialcovid19infectioninalongtermhospitalinspainretrospectiveobservationalstudy
AT ramosrinconjosemanuel nosocomialcovid19infectioninalongtermhospitalinspainretrospectiveobservationalstudy