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Antibiotic Administration within Two Days after Successful Endoscopic Retrograde Cholangiopancreatography Is Sufficient for Mild and Moderate Acute Cholangitis

To prevent the increase of resistant bacteria, it is important to minimize the use of antimicrobial agents. Studies have found that administration for ≤3 days after successful endoscopic retrograde cholangiopancreatography (ERCP) is appropriate. Therefore, the present study aimed to verify if admini...

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Autores principales: Masuda, Sakue, Koizumi, Kazuya, Makazu, Makomo, Uojima, Haruki, Kubota, Jun, Kimura, Karen, Nishino, Takashi, Sumida, Chihiro, Ichita, Chikamasa, Sasaki, Akiko, Shionoya, Kento
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143657/
https://www.ncbi.nlm.nih.gov/pubmed/35628824
http://dx.doi.org/10.3390/jcm11102697
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author Masuda, Sakue
Koizumi, Kazuya
Makazu, Makomo
Uojima, Haruki
Kubota, Jun
Kimura, Karen
Nishino, Takashi
Sumida, Chihiro
Ichita, Chikamasa
Sasaki, Akiko
Shionoya, Kento
author_facet Masuda, Sakue
Koizumi, Kazuya
Makazu, Makomo
Uojima, Haruki
Kubota, Jun
Kimura, Karen
Nishino, Takashi
Sumida, Chihiro
Ichita, Chikamasa
Sasaki, Akiko
Shionoya, Kento
author_sort Masuda, Sakue
collection PubMed
description To prevent the increase of resistant bacteria, it is important to minimize the use of antimicrobial agents. Studies have found that administration for ≤3 days after successful endoscopic retrograde cholangiopancreatography (ERCP) is appropriate. Therefore, the present study aimed to verify if administration of antimicrobial agents can be further shortened to ≤2 days after ERCP. We divided 390 patients with mild and moderate cholangitis who underwent technically successful ERCP from January 2018 to June 2020 and had positive blood or bile cultures into two groups: antibiotic therapy within two days of ERCP (short-course therapy, SCT; n = 59, 15.1%), and for >3 days (long-course therapy, LCT; n = 331, 84.9%). The increased severity after admission and other outcomes were compared between the two groups, and the risk factors for increased severity were verified. There were no between-group differences in patient characteristics. Total length of hospital stay was shorter in SCT than in LCT, and other outcomes in SCT were not significantly different from those in LCT. Being 80 or older was a risk factor for increased severity; however, SCT was not associated with increased severity. Antimicrobial therapy for ≤2 days after successful ERCP is adequate in patients with mild and moderate acute cholangitis.
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spelling pubmed-91436572022-05-29 Antibiotic Administration within Two Days after Successful Endoscopic Retrograde Cholangiopancreatography Is Sufficient for Mild and Moderate Acute Cholangitis Masuda, Sakue Koizumi, Kazuya Makazu, Makomo Uojima, Haruki Kubota, Jun Kimura, Karen Nishino, Takashi Sumida, Chihiro Ichita, Chikamasa Sasaki, Akiko Shionoya, Kento J Clin Med Article To prevent the increase of resistant bacteria, it is important to minimize the use of antimicrobial agents. Studies have found that administration for ≤3 days after successful endoscopic retrograde cholangiopancreatography (ERCP) is appropriate. Therefore, the present study aimed to verify if administration of antimicrobial agents can be further shortened to ≤2 days after ERCP. We divided 390 patients with mild and moderate cholangitis who underwent technically successful ERCP from January 2018 to June 2020 and had positive blood or bile cultures into two groups: antibiotic therapy within two days of ERCP (short-course therapy, SCT; n = 59, 15.1%), and for >3 days (long-course therapy, LCT; n = 331, 84.9%). The increased severity after admission and other outcomes were compared between the two groups, and the risk factors for increased severity were verified. There were no between-group differences in patient characteristics. Total length of hospital stay was shorter in SCT than in LCT, and other outcomes in SCT were not significantly different from those in LCT. Being 80 or older was a risk factor for increased severity; however, SCT was not associated with increased severity. Antimicrobial therapy for ≤2 days after successful ERCP is adequate in patients with mild and moderate acute cholangitis. MDPI 2022-05-10 /pmc/articles/PMC9143657/ /pubmed/35628824 http://dx.doi.org/10.3390/jcm11102697 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Masuda, Sakue
Koizumi, Kazuya
Makazu, Makomo
Uojima, Haruki
Kubota, Jun
Kimura, Karen
Nishino, Takashi
Sumida, Chihiro
Ichita, Chikamasa
Sasaki, Akiko
Shionoya, Kento
Antibiotic Administration within Two Days after Successful Endoscopic Retrograde Cholangiopancreatography Is Sufficient for Mild and Moderate Acute Cholangitis
title Antibiotic Administration within Two Days after Successful Endoscopic Retrograde Cholangiopancreatography Is Sufficient for Mild and Moderate Acute Cholangitis
title_full Antibiotic Administration within Two Days after Successful Endoscopic Retrograde Cholangiopancreatography Is Sufficient for Mild and Moderate Acute Cholangitis
title_fullStr Antibiotic Administration within Two Days after Successful Endoscopic Retrograde Cholangiopancreatography Is Sufficient for Mild and Moderate Acute Cholangitis
title_full_unstemmed Antibiotic Administration within Two Days after Successful Endoscopic Retrograde Cholangiopancreatography Is Sufficient for Mild and Moderate Acute Cholangitis
title_short Antibiotic Administration within Two Days after Successful Endoscopic Retrograde Cholangiopancreatography Is Sufficient for Mild and Moderate Acute Cholangitis
title_sort antibiotic administration within two days after successful endoscopic retrograde cholangiopancreatography is sufficient for mild and moderate acute cholangitis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143657/
https://www.ncbi.nlm.nih.gov/pubmed/35628824
http://dx.doi.org/10.3390/jcm11102697
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