Anti-Obesity Effect of Dyglomera(®) Is Associated with Activation of the AMPK Signaling Pathway in 3T3-L1 Adipocytes and Mice with High-Fat Diet-Induced Obesity

Dyglomera(®) is an aqueous ethanol extract of the fruit pods of Dichrostachys glomerata, a Cameroonian spice. Several studies have shown its anti-diabetic and anti-obesity effects. However, the underlying mechanisms for such effects remain unclear. Thus, the objective of this study was to investigat...

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Autores principales: Kim, Hae-Lim, Lee, Sung-Kwon, Min, Da-Eun, Choi, Bong-Keun, Lee, Dong-Ryung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143725/
https://www.ncbi.nlm.nih.gov/pubmed/35630765
http://dx.doi.org/10.3390/molecules27103288
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author Kim, Hae-Lim
Lee, Sung-Kwon
Min, Da-Eun
Choi, Bong-Keun
Lee, Dong-Ryung
author_facet Kim, Hae-Lim
Lee, Sung-Kwon
Min, Da-Eun
Choi, Bong-Keun
Lee, Dong-Ryung
author_sort Kim, Hae-Lim
collection PubMed
description Dyglomera(®) is an aqueous ethanol extract of the fruit pods of Dichrostachys glomerata, a Cameroonian spice. Several studies have shown its anti-diabetic and anti-obesity effects. However, the underlying mechanisms for such effects remain unclear. Thus, the objective of this study was to investigate the anti-obesity effect of Dyglomera(®) and its underlying mechanisms in mice with high-fat diet-induced obesity and 3T3-L1 adipocytes. Our results revealed that Dyglomera(®) inhibited adipogenesis and lipogenesis by regulating AMPK phosphorylation in white adipose tissues (WATs) and 3T3-L1 adipocytes and promoted lipolysis by increasing the expression of lipolysis-related proteins. These results suggest that Dyglomera(®) can be used as an effective dietary supplement for treating obesity due to its modulating effect on adipogenesis/lipogenesis and lipolysis.
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spelling pubmed-91437252022-05-29 Anti-Obesity Effect of Dyglomera(®) Is Associated with Activation of the AMPK Signaling Pathway in 3T3-L1 Adipocytes and Mice with High-Fat Diet-Induced Obesity Kim, Hae-Lim Lee, Sung-Kwon Min, Da-Eun Choi, Bong-Keun Lee, Dong-Ryung Molecules Article Dyglomera(®) is an aqueous ethanol extract of the fruit pods of Dichrostachys glomerata, a Cameroonian spice. Several studies have shown its anti-diabetic and anti-obesity effects. However, the underlying mechanisms for such effects remain unclear. Thus, the objective of this study was to investigate the anti-obesity effect of Dyglomera(®) and its underlying mechanisms in mice with high-fat diet-induced obesity and 3T3-L1 adipocytes. Our results revealed that Dyglomera(®) inhibited adipogenesis and lipogenesis by regulating AMPK phosphorylation in white adipose tissues (WATs) and 3T3-L1 adipocytes and promoted lipolysis by increasing the expression of lipolysis-related proteins. These results suggest that Dyglomera(®) can be used as an effective dietary supplement for treating obesity due to its modulating effect on adipogenesis/lipogenesis and lipolysis. MDPI 2022-05-20 /pmc/articles/PMC9143725/ /pubmed/35630765 http://dx.doi.org/10.3390/molecules27103288 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Hae-Lim
Lee, Sung-Kwon
Min, Da-Eun
Choi, Bong-Keun
Lee, Dong-Ryung
Anti-Obesity Effect of Dyglomera(®) Is Associated with Activation of the AMPK Signaling Pathway in 3T3-L1 Adipocytes and Mice with High-Fat Diet-Induced Obesity
title Anti-Obesity Effect of Dyglomera(®) Is Associated with Activation of the AMPK Signaling Pathway in 3T3-L1 Adipocytes and Mice with High-Fat Diet-Induced Obesity
title_full Anti-Obesity Effect of Dyglomera(®) Is Associated with Activation of the AMPK Signaling Pathway in 3T3-L1 Adipocytes and Mice with High-Fat Diet-Induced Obesity
title_fullStr Anti-Obesity Effect of Dyglomera(®) Is Associated with Activation of the AMPK Signaling Pathway in 3T3-L1 Adipocytes and Mice with High-Fat Diet-Induced Obesity
title_full_unstemmed Anti-Obesity Effect of Dyglomera(®) Is Associated with Activation of the AMPK Signaling Pathway in 3T3-L1 Adipocytes and Mice with High-Fat Diet-Induced Obesity
title_short Anti-Obesity Effect of Dyglomera(®) Is Associated with Activation of the AMPK Signaling Pathway in 3T3-L1 Adipocytes and Mice with High-Fat Diet-Induced Obesity
title_sort anti-obesity effect of dyglomera(®) is associated with activation of the ampk signaling pathway in 3t3-l1 adipocytes and mice with high-fat diet-induced obesity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143725/
https://www.ncbi.nlm.nih.gov/pubmed/35630765
http://dx.doi.org/10.3390/molecules27103288
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