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Efficiency of Hyaluronic Acid in Infrabony Defects: A Systematic Review of Human Clinical Trials

Background and objectives: The aim of this systematic review was to assess the electronic literature about the benefits of using hyaluronic acid (HA) in the surgical periodontal treatment of infrabony defects. Materials and methods: This review was conducted under the PRISMA guidelines. The electron...

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Autores principales: Onisor, Florin, Bran, Simion, Mester, Alexandru, Voina-Tonea, Andrada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143907/
https://www.ncbi.nlm.nih.gov/pubmed/35629997
http://dx.doi.org/10.3390/medicina58050580
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author Onisor, Florin
Bran, Simion
Mester, Alexandru
Voina-Tonea, Andrada
author_facet Onisor, Florin
Bran, Simion
Mester, Alexandru
Voina-Tonea, Andrada
author_sort Onisor, Florin
collection PubMed
description Background and objectives: The aim of this systematic review was to assess the electronic literature about the benefits of using hyaluronic acid (HA) in the surgical periodontal treatment of infrabony defects. Materials and methods: This review was conducted under the PRISMA guidelines. The electronic search was conducted on PubMed, Scopus, Web of Science, and Cochrane databases until February 2022. The inclusion criteria consisted of human clinical trials that reported the use of HA in open-flap debridement (OFD) for infrabony defects. The assessment of risk of bias was performed using the Cochrane risk of bias tool. Statistical analysis was performed using Review Manager. Results: Overall, three RCTs were found eligible for the statistical analysis. Probing depth (PD) reduction and clinical attachment level (CAL) gain in the HA test group presented WMs of −1.11 mm (95% CI −2.38 to 0.16 mm; p = 0.09) and −1.38 mm (95% CI −2.26 to −0.49 mm; p = 0.002), respectively. However, the heterogeneity of the RCTs was high, and the risk of bias, in general, was low. Conclusions: The use of hyaluronic acid seems to have beneficial effects in periodontal surgery using OFD, in terms of PD and CAL. To draw a clear conclusion, more adapted and well-designed clinical trials are needed to assess the advantage of this product in comparison with other products.
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spelling pubmed-91439072022-05-29 Efficiency of Hyaluronic Acid in Infrabony Defects: A Systematic Review of Human Clinical Trials Onisor, Florin Bran, Simion Mester, Alexandru Voina-Tonea, Andrada Medicina (Kaunas) Systematic Review Background and objectives: The aim of this systematic review was to assess the electronic literature about the benefits of using hyaluronic acid (HA) in the surgical periodontal treatment of infrabony defects. Materials and methods: This review was conducted under the PRISMA guidelines. The electronic search was conducted on PubMed, Scopus, Web of Science, and Cochrane databases until February 2022. The inclusion criteria consisted of human clinical trials that reported the use of HA in open-flap debridement (OFD) for infrabony defects. The assessment of risk of bias was performed using the Cochrane risk of bias tool. Statistical analysis was performed using Review Manager. Results: Overall, three RCTs were found eligible for the statistical analysis. Probing depth (PD) reduction and clinical attachment level (CAL) gain in the HA test group presented WMs of −1.11 mm (95% CI −2.38 to 0.16 mm; p = 0.09) and −1.38 mm (95% CI −2.26 to −0.49 mm; p = 0.002), respectively. However, the heterogeneity of the RCTs was high, and the risk of bias, in general, was low. Conclusions: The use of hyaluronic acid seems to have beneficial effects in periodontal surgery using OFD, in terms of PD and CAL. To draw a clear conclusion, more adapted and well-designed clinical trials are needed to assess the advantage of this product in comparison with other products. MDPI 2022-04-23 /pmc/articles/PMC9143907/ /pubmed/35629997 http://dx.doi.org/10.3390/medicina58050580 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Onisor, Florin
Bran, Simion
Mester, Alexandru
Voina-Tonea, Andrada
Efficiency of Hyaluronic Acid in Infrabony Defects: A Systematic Review of Human Clinical Trials
title Efficiency of Hyaluronic Acid in Infrabony Defects: A Systematic Review of Human Clinical Trials
title_full Efficiency of Hyaluronic Acid in Infrabony Defects: A Systematic Review of Human Clinical Trials
title_fullStr Efficiency of Hyaluronic Acid in Infrabony Defects: A Systematic Review of Human Clinical Trials
title_full_unstemmed Efficiency of Hyaluronic Acid in Infrabony Defects: A Systematic Review of Human Clinical Trials
title_short Efficiency of Hyaluronic Acid in Infrabony Defects: A Systematic Review of Human Clinical Trials
title_sort efficiency of hyaluronic acid in infrabony defects: a systematic review of human clinical trials
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143907/
https://www.ncbi.nlm.nih.gov/pubmed/35629997
http://dx.doi.org/10.3390/medicina58050580
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