Cargando…

Curcumin: Useful add-on for Rheumatic Diseases?

Plant-derived nutraceuticals are proposed as new key instruments to represent a profound “back to basics” shift in medical treatment. Data accumulated over the past ten years suggest that curcumin, the major active compound of the turmeric plant, has anti-inflammatory properties. It has yet to be de...

Descripción completa

Detalles Bibliográficos
Autores principales: Tomaras, Stylianos, Keyßer, Gernot, Feist, Eugen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143911/
https://www.ncbi.nlm.nih.gov/pubmed/35629033
http://dx.doi.org/10.3390/jcm11102908
_version_ 1784715922029674496
author Tomaras, Stylianos
Keyßer, Gernot
Feist, Eugen
author_facet Tomaras, Stylianos
Keyßer, Gernot
Feist, Eugen
author_sort Tomaras, Stylianos
collection PubMed
description Plant-derived nutraceuticals are proposed as new key instruments to represent a profound “back to basics” shift in medical treatment. Data accumulated over the past ten years suggest that curcumin, the major active compound of the turmeric plant, has anti-inflammatory properties. It has yet to be determined whether the anti-inflammatory profile of curcumin is potent enough to justify the application of this substance as a nutritional supplement for patients with rheumatic diseases. To address this question, the most relevant in vitro studies that investigate the mechanism of action of curcumin were reviewed in this article. In addition, a total of 18 animal and human trials were evaluated. The pleiotropic, anti-inflammatory and immunomodulatory effects of curcumin were observed in animal studies. In addition, human trials demonstrated promising findings. In these studies, curcumin was able to reduce the expression of proinflammatory cytokines, lower the level of the C-reactive protein and improve clinical parameters. A limiting factor of the application of curcumin is the inconsistent bioavailability of the substance. Therefore, new formulations have been developed to improve the pharmacodynamic profile of curcumin. The future acceptance of the substance is dependent on new controlled clinical trials with a standardised formulation of curcumin administered as well as standard of care.
format Online
Article
Text
id pubmed-9143911
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-91439112022-05-29 Curcumin: Useful add-on for Rheumatic Diseases? Tomaras, Stylianos Keyßer, Gernot Feist, Eugen J Clin Med Review Plant-derived nutraceuticals are proposed as new key instruments to represent a profound “back to basics” shift in medical treatment. Data accumulated over the past ten years suggest that curcumin, the major active compound of the turmeric plant, has anti-inflammatory properties. It has yet to be determined whether the anti-inflammatory profile of curcumin is potent enough to justify the application of this substance as a nutritional supplement for patients with rheumatic diseases. To address this question, the most relevant in vitro studies that investigate the mechanism of action of curcumin were reviewed in this article. In addition, a total of 18 animal and human trials were evaluated. The pleiotropic, anti-inflammatory and immunomodulatory effects of curcumin were observed in animal studies. In addition, human trials demonstrated promising findings. In these studies, curcumin was able to reduce the expression of proinflammatory cytokines, lower the level of the C-reactive protein and improve clinical parameters. A limiting factor of the application of curcumin is the inconsistent bioavailability of the substance. Therefore, new formulations have been developed to improve the pharmacodynamic profile of curcumin. The future acceptance of the substance is dependent on new controlled clinical trials with a standardised formulation of curcumin administered as well as standard of care. MDPI 2022-05-20 /pmc/articles/PMC9143911/ /pubmed/35629033 http://dx.doi.org/10.3390/jcm11102908 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tomaras, Stylianos
Keyßer, Gernot
Feist, Eugen
Curcumin: Useful add-on for Rheumatic Diseases?
title Curcumin: Useful add-on for Rheumatic Diseases?
title_full Curcumin: Useful add-on for Rheumatic Diseases?
title_fullStr Curcumin: Useful add-on for Rheumatic Diseases?
title_full_unstemmed Curcumin: Useful add-on for Rheumatic Diseases?
title_short Curcumin: Useful add-on for Rheumatic Diseases?
title_sort curcumin: useful add-on for rheumatic diseases?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143911/
https://www.ncbi.nlm.nih.gov/pubmed/35629033
http://dx.doi.org/10.3390/jcm11102908
work_keys_str_mv AT tomarasstylianos curcuminusefuladdonforrheumaticdiseases
AT keyßergernot curcuminusefuladdonforrheumaticdiseases
AT feisteugen curcuminusefuladdonforrheumaticdiseases