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Eprinomectin and Moxidectin Resistance of Trichostrongyloids on a Goat Farm in Austria

Anthelmintic resistance (AR) of trichostrongyloids is widespread in Europe, but there is no up-to-date information on the spread of AR in caprine parasites in Austria. Eprinomectin (EPR) is currently the only anthelmintic drug of the macrocyclic lactones registered for goats in Europe. The aim of th...

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Autores principales: Hinney, Barbara, Wiedermann, Sandra, Kaiser, Waltraud, Krücken, Jürgen, Joachim, Anja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143937/
https://www.ncbi.nlm.nih.gov/pubmed/35631019
http://dx.doi.org/10.3390/pathogens11050498
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author Hinney, Barbara
Wiedermann, Sandra
Kaiser, Waltraud
Krücken, Jürgen
Joachim, Anja
author_facet Hinney, Barbara
Wiedermann, Sandra
Kaiser, Waltraud
Krücken, Jürgen
Joachim, Anja
author_sort Hinney, Barbara
collection PubMed
description Anthelmintic resistance (AR) of trichostrongyloids is widespread in Europe, but there is no up-to-date information on the spread of AR in caprine parasites in Austria. Eprinomectin (EPR) is currently the only anthelmintic drug of the macrocyclic lactones registered for goats in Europe. The aim of the present study was to gather information regarding the efficacy of anthelmintics against trichostrongyloids on a dairy goat farm in Austria with reported treatment failure of macrocyclic lactones and to determine the presence of different trichostrongyloid genera. Faecal egg count reduction tests (FECRT) using Mini-FLOTAC were performed with eprinomectin (EPR) and moxidectin (MOX). Egg count reduction, calculated with the R package egg-Counts, was 44% for EPR and 86% for MOX, confirming AR of trichostrongyloids for both compounds. The most frequently detected genus in larval cultures was Haemonchus, followed by Trichostrongylus. This is the first report of MOX resistance in caprine trichostrongyloids in Europe. Failure of EPR and MOX to control trichostrongyloid infections is a severe threat to dairy goat farming, since other compounds must not be applied in goats used for milk production. Haemonchus contortus is one of the most pathogenic parasites of small ruminants and can quickly develop AR. Thus, immediate action should be taken to slow the further spread of AR in this and other roundworm species of ruminants in Austria.
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spelling pubmed-91439372022-05-29 Eprinomectin and Moxidectin Resistance of Trichostrongyloids on a Goat Farm in Austria Hinney, Barbara Wiedermann, Sandra Kaiser, Waltraud Krücken, Jürgen Joachim, Anja Pathogens Communication Anthelmintic resistance (AR) of trichostrongyloids is widespread in Europe, but there is no up-to-date information on the spread of AR in caprine parasites in Austria. Eprinomectin (EPR) is currently the only anthelmintic drug of the macrocyclic lactones registered for goats in Europe. The aim of the present study was to gather information regarding the efficacy of anthelmintics against trichostrongyloids on a dairy goat farm in Austria with reported treatment failure of macrocyclic lactones and to determine the presence of different trichostrongyloid genera. Faecal egg count reduction tests (FECRT) using Mini-FLOTAC were performed with eprinomectin (EPR) and moxidectin (MOX). Egg count reduction, calculated with the R package egg-Counts, was 44% for EPR and 86% for MOX, confirming AR of trichostrongyloids for both compounds. The most frequently detected genus in larval cultures was Haemonchus, followed by Trichostrongylus. This is the first report of MOX resistance in caprine trichostrongyloids in Europe. Failure of EPR and MOX to control trichostrongyloid infections is a severe threat to dairy goat farming, since other compounds must not be applied in goats used for milk production. Haemonchus contortus is one of the most pathogenic parasites of small ruminants and can quickly develop AR. Thus, immediate action should be taken to slow the further spread of AR in this and other roundworm species of ruminants in Austria. MDPI 2022-04-21 /pmc/articles/PMC9143937/ /pubmed/35631019 http://dx.doi.org/10.3390/pathogens11050498 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Hinney, Barbara
Wiedermann, Sandra
Kaiser, Waltraud
Krücken, Jürgen
Joachim, Anja
Eprinomectin and Moxidectin Resistance of Trichostrongyloids on a Goat Farm in Austria
title Eprinomectin and Moxidectin Resistance of Trichostrongyloids on a Goat Farm in Austria
title_full Eprinomectin and Moxidectin Resistance of Trichostrongyloids on a Goat Farm in Austria
title_fullStr Eprinomectin and Moxidectin Resistance of Trichostrongyloids on a Goat Farm in Austria
title_full_unstemmed Eprinomectin and Moxidectin Resistance of Trichostrongyloids on a Goat Farm in Austria
title_short Eprinomectin and Moxidectin Resistance of Trichostrongyloids on a Goat Farm in Austria
title_sort eprinomectin and moxidectin resistance of trichostrongyloids on a goat farm in austria
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143937/
https://www.ncbi.nlm.nih.gov/pubmed/35631019
http://dx.doi.org/10.3390/pathogens11050498
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