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Non-Alcoholic Fatty Liver Disease in Long-Term Type 2 Diabetes: Role of rs738409 PNPLA3 and rs499765 FGF21 Polymorphisms and Serum Biomarkers

Fibroblast growth factor 21 (FGF21) signaling and genetic factors are involved in non-alcoholic fatty liver disease (NAFLD) pathogenesis. However, these factors have rarely been studied in type 2 diabetes mellitus (T2D) patients from admixed populations such as in those of Brazil. Therefore, we aime...

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Autores principales: Mana, Mauy Frujuello, Parisi, Maria Cândida R., Correa-Giannella, Maria Lucia, Neto, Arnaldo Moura, Yamanaka, Ademar, Cunha-Silva, Marlone, Cavaleiro, Ana Mercedes, dos Santos, Cristina Rodrigues, Pavan, Célia Regina, Sevá-Pereira, Tiago, Dertkigil, Sergio S. J., Mazo, Daniel F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143959/
https://www.ncbi.nlm.nih.gov/pubmed/35630668
http://dx.doi.org/10.3390/molecules27103193
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author Mana, Mauy Frujuello
Parisi, Maria Cândida R.
Correa-Giannella, Maria Lucia
Neto, Arnaldo Moura
Yamanaka, Ademar
Cunha-Silva, Marlone
Cavaleiro, Ana Mercedes
dos Santos, Cristina Rodrigues
Pavan, Célia Regina
Sevá-Pereira, Tiago
Dertkigil, Sergio S. J.
Mazo, Daniel F.
author_facet Mana, Mauy Frujuello
Parisi, Maria Cândida R.
Correa-Giannella, Maria Lucia
Neto, Arnaldo Moura
Yamanaka, Ademar
Cunha-Silva, Marlone
Cavaleiro, Ana Mercedes
dos Santos, Cristina Rodrigues
Pavan, Célia Regina
Sevá-Pereira, Tiago
Dertkigil, Sergio S. J.
Mazo, Daniel F.
author_sort Mana, Mauy Frujuello
collection PubMed
description Fibroblast growth factor 21 (FGF21) signaling and genetic factors are involved in non-alcoholic fatty liver disease (NAFLD) pathogenesis. However, these factors have rarely been studied in type 2 diabetes mellitus (T2D) patients from admixed populations such as in those of Brazil. Therefore, we aimed to evaluate rs738409 patanin-like phospholipase domain-containing protein (PNPLA3) and rs499765 FGF21 polymorphisms in T2D, and their association with NAFLD, liver fibrosis, and serum biomarkers (FGF21 and cytokeratin 18 levels). A total of 158 patients were included, and the frequency of NAFLD was 88.6%, which was independently associated with elevated body mass index. Significant liver fibrosis (≥F2) was detected by transient elastography (TE) in 26.8% of NAFLD patients, and was independently associated with obesity, low density lipoprotein, and gamma-glutamyl transferase (GGT). PNPLA3 GG genotype and GGT were independently associated with cirrhosis. PNPLA3 GG genotype patients had higher GGT and AST levels; PNPLA3 GG carriers had higher TE values than CG patients, and FGF21 CG genotype patients showed lower gamma-GT values than CC patients. No differences were found in serum values of FGF21 and CK18 in relation to the presence of NAFLD or liver fibrosis. The proportion of NAFLD patients with liver fibrosis was relevant in the present admixed T2D population, and was associated with PNPLA3 polymorphisms.
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spelling pubmed-91439592022-05-29 Non-Alcoholic Fatty Liver Disease in Long-Term Type 2 Diabetes: Role of rs738409 PNPLA3 and rs499765 FGF21 Polymorphisms and Serum Biomarkers Mana, Mauy Frujuello Parisi, Maria Cândida R. Correa-Giannella, Maria Lucia Neto, Arnaldo Moura Yamanaka, Ademar Cunha-Silva, Marlone Cavaleiro, Ana Mercedes dos Santos, Cristina Rodrigues Pavan, Célia Regina Sevá-Pereira, Tiago Dertkigil, Sergio S. J. Mazo, Daniel F. Molecules Article Fibroblast growth factor 21 (FGF21) signaling and genetic factors are involved in non-alcoholic fatty liver disease (NAFLD) pathogenesis. However, these factors have rarely been studied in type 2 diabetes mellitus (T2D) patients from admixed populations such as in those of Brazil. Therefore, we aimed to evaluate rs738409 patanin-like phospholipase domain-containing protein (PNPLA3) and rs499765 FGF21 polymorphisms in T2D, and their association with NAFLD, liver fibrosis, and serum biomarkers (FGF21 and cytokeratin 18 levels). A total of 158 patients were included, and the frequency of NAFLD was 88.6%, which was independently associated with elevated body mass index. Significant liver fibrosis (≥F2) was detected by transient elastography (TE) in 26.8% of NAFLD patients, and was independently associated with obesity, low density lipoprotein, and gamma-glutamyl transferase (GGT). PNPLA3 GG genotype and GGT were independently associated with cirrhosis. PNPLA3 GG genotype patients had higher GGT and AST levels; PNPLA3 GG carriers had higher TE values than CG patients, and FGF21 CG genotype patients showed lower gamma-GT values than CC patients. No differences were found in serum values of FGF21 and CK18 in relation to the presence of NAFLD or liver fibrosis. The proportion of NAFLD patients with liver fibrosis was relevant in the present admixed T2D population, and was associated with PNPLA3 polymorphisms. MDPI 2022-05-17 /pmc/articles/PMC9143959/ /pubmed/35630668 http://dx.doi.org/10.3390/molecules27103193 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mana, Mauy Frujuello
Parisi, Maria Cândida R.
Correa-Giannella, Maria Lucia
Neto, Arnaldo Moura
Yamanaka, Ademar
Cunha-Silva, Marlone
Cavaleiro, Ana Mercedes
dos Santos, Cristina Rodrigues
Pavan, Célia Regina
Sevá-Pereira, Tiago
Dertkigil, Sergio S. J.
Mazo, Daniel F.
Non-Alcoholic Fatty Liver Disease in Long-Term Type 2 Diabetes: Role of rs738409 PNPLA3 and rs499765 FGF21 Polymorphisms and Serum Biomarkers
title Non-Alcoholic Fatty Liver Disease in Long-Term Type 2 Diabetes: Role of rs738409 PNPLA3 and rs499765 FGF21 Polymorphisms and Serum Biomarkers
title_full Non-Alcoholic Fatty Liver Disease in Long-Term Type 2 Diabetes: Role of rs738409 PNPLA3 and rs499765 FGF21 Polymorphisms and Serum Biomarkers
title_fullStr Non-Alcoholic Fatty Liver Disease in Long-Term Type 2 Diabetes: Role of rs738409 PNPLA3 and rs499765 FGF21 Polymorphisms and Serum Biomarkers
title_full_unstemmed Non-Alcoholic Fatty Liver Disease in Long-Term Type 2 Diabetes: Role of rs738409 PNPLA3 and rs499765 FGF21 Polymorphisms and Serum Biomarkers
title_short Non-Alcoholic Fatty Liver Disease in Long-Term Type 2 Diabetes: Role of rs738409 PNPLA3 and rs499765 FGF21 Polymorphisms and Serum Biomarkers
title_sort non-alcoholic fatty liver disease in long-term type 2 diabetes: role of rs738409 pnpla3 and rs499765 fgf21 polymorphisms and serum biomarkers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143959/
https://www.ncbi.nlm.nih.gov/pubmed/35630668
http://dx.doi.org/10.3390/molecules27103193
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