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Dysregulated miRNAs as Biomarkers and Therapeutical Targets in Neurodegenerative Diseases
Alzheimer’s disease (AD), Parkinson’s disease (PD), and Amyotrophic Lateral Sclerosis (ALS) are representative neurodegenerative diseases (NDs) characterized by degeneration of selective neurons, as well as the lack of effective biomarkers and therapeutic treatments. In the last decade, microRNAs (m...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143965/ https://www.ncbi.nlm.nih.gov/pubmed/35629192 http://dx.doi.org/10.3390/jpm12050770 |
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author | Gentile, Giulia Morello, Giovanna La Cognata, Valentina Guarnaccia, Maria Conforti, Francesca Luisa Cavallaro, Sebastiano |
author_facet | Gentile, Giulia Morello, Giovanna La Cognata, Valentina Guarnaccia, Maria Conforti, Francesca Luisa Cavallaro, Sebastiano |
author_sort | Gentile, Giulia |
collection | PubMed |
description | Alzheimer’s disease (AD), Parkinson’s disease (PD), and Amyotrophic Lateral Sclerosis (ALS) are representative neurodegenerative diseases (NDs) characterized by degeneration of selective neurons, as well as the lack of effective biomarkers and therapeutic treatments. In the last decade, microRNAs (miRNAs) have gained considerable interest in diagnostics and therapy of NDs, owing to their aberrant expression and their ability to target multiple molecules and pathways. Here, we provide an overview of dysregulated miRNAs in fluids (blood or cerebrospinal fluid) and nervous tissue of AD, PD, and ALS patients. By emphasizing those that are commonly dysregulated in these NDs, we highlight their potential role as biomarkers or therapeutical targets and describe the use of antisense oligonucleotides as miRNA therapies. |
format | Online Article Text |
id | pubmed-9143965 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91439652022-05-29 Dysregulated miRNAs as Biomarkers and Therapeutical Targets in Neurodegenerative Diseases Gentile, Giulia Morello, Giovanna La Cognata, Valentina Guarnaccia, Maria Conforti, Francesca Luisa Cavallaro, Sebastiano J Pers Med Review Alzheimer’s disease (AD), Parkinson’s disease (PD), and Amyotrophic Lateral Sclerosis (ALS) are representative neurodegenerative diseases (NDs) characterized by degeneration of selective neurons, as well as the lack of effective biomarkers and therapeutic treatments. In the last decade, microRNAs (miRNAs) have gained considerable interest in diagnostics and therapy of NDs, owing to their aberrant expression and their ability to target multiple molecules and pathways. Here, we provide an overview of dysregulated miRNAs in fluids (blood or cerebrospinal fluid) and nervous tissue of AD, PD, and ALS patients. By emphasizing those that are commonly dysregulated in these NDs, we highlight their potential role as biomarkers or therapeutical targets and describe the use of antisense oligonucleotides as miRNA therapies. MDPI 2022-05-10 /pmc/articles/PMC9143965/ /pubmed/35629192 http://dx.doi.org/10.3390/jpm12050770 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gentile, Giulia Morello, Giovanna La Cognata, Valentina Guarnaccia, Maria Conforti, Francesca Luisa Cavallaro, Sebastiano Dysregulated miRNAs as Biomarkers and Therapeutical Targets in Neurodegenerative Diseases |
title | Dysregulated miRNAs as Biomarkers and Therapeutical Targets in Neurodegenerative Diseases |
title_full | Dysregulated miRNAs as Biomarkers and Therapeutical Targets in Neurodegenerative Diseases |
title_fullStr | Dysregulated miRNAs as Biomarkers and Therapeutical Targets in Neurodegenerative Diseases |
title_full_unstemmed | Dysregulated miRNAs as Biomarkers and Therapeutical Targets in Neurodegenerative Diseases |
title_short | Dysregulated miRNAs as Biomarkers and Therapeutical Targets in Neurodegenerative Diseases |
title_sort | dysregulated mirnas as biomarkers and therapeutical targets in neurodegenerative diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143965/ https://www.ncbi.nlm.nih.gov/pubmed/35629192 http://dx.doi.org/10.3390/jpm12050770 |
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