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Dysregulated miRNAs as Biomarkers and Therapeutical Targets in Neurodegenerative Diseases

Alzheimer’s disease (AD), Parkinson’s disease (PD), and Amyotrophic Lateral Sclerosis (ALS) are representative neurodegenerative diseases (NDs) characterized by degeneration of selective neurons, as well as the lack of effective biomarkers and therapeutic treatments. In the last decade, microRNAs (m...

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Autores principales: Gentile, Giulia, Morello, Giovanna, La Cognata, Valentina, Guarnaccia, Maria, Conforti, Francesca Luisa, Cavallaro, Sebastiano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143965/
https://www.ncbi.nlm.nih.gov/pubmed/35629192
http://dx.doi.org/10.3390/jpm12050770
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author Gentile, Giulia
Morello, Giovanna
La Cognata, Valentina
Guarnaccia, Maria
Conforti, Francesca Luisa
Cavallaro, Sebastiano
author_facet Gentile, Giulia
Morello, Giovanna
La Cognata, Valentina
Guarnaccia, Maria
Conforti, Francesca Luisa
Cavallaro, Sebastiano
author_sort Gentile, Giulia
collection PubMed
description Alzheimer’s disease (AD), Parkinson’s disease (PD), and Amyotrophic Lateral Sclerosis (ALS) are representative neurodegenerative diseases (NDs) characterized by degeneration of selective neurons, as well as the lack of effective biomarkers and therapeutic treatments. In the last decade, microRNAs (miRNAs) have gained considerable interest in diagnostics and therapy of NDs, owing to their aberrant expression and their ability to target multiple molecules and pathways. Here, we provide an overview of dysregulated miRNAs in fluids (blood or cerebrospinal fluid) and nervous tissue of AD, PD, and ALS patients. By emphasizing those that are commonly dysregulated in these NDs, we highlight their potential role as biomarkers or therapeutical targets and describe the use of antisense oligonucleotides as miRNA therapies.
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spelling pubmed-91439652022-05-29 Dysregulated miRNAs as Biomarkers and Therapeutical Targets in Neurodegenerative Diseases Gentile, Giulia Morello, Giovanna La Cognata, Valentina Guarnaccia, Maria Conforti, Francesca Luisa Cavallaro, Sebastiano J Pers Med Review Alzheimer’s disease (AD), Parkinson’s disease (PD), and Amyotrophic Lateral Sclerosis (ALS) are representative neurodegenerative diseases (NDs) characterized by degeneration of selective neurons, as well as the lack of effective biomarkers and therapeutic treatments. In the last decade, microRNAs (miRNAs) have gained considerable interest in diagnostics and therapy of NDs, owing to their aberrant expression and their ability to target multiple molecules and pathways. Here, we provide an overview of dysregulated miRNAs in fluids (blood or cerebrospinal fluid) and nervous tissue of AD, PD, and ALS patients. By emphasizing those that are commonly dysregulated in these NDs, we highlight their potential role as biomarkers or therapeutical targets and describe the use of antisense oligonucleotides as miRNA therapies. MDPI 2022-05-10 /pmc/articles/PMC9143965/ /pubmed/35629192 http://dx.doi.org/10.3390/jpm12050770 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gentile, Giulia
Morello, Giovanna
La Cognata, Valentina
Guarnaccia, Maria
Conforti, Francesca Luisa
Cavallaro, Sebastiano
Dysregulated miRNAs as Biomarkers and Therapeutical Targets in Neurodegenerative Diseases
title Dysregulated miRNAs as Biomarkers and Therapeutical Targets in Neurodegenerative Diseases
title_full Dysregulated miRNAs as Biomarkers and Therapeutical Targets in Neurodegenerative Diseases
title_fullStr Dysregulated miRNAs as Biomarkers and Therapeutical Targets in Neurodegenerative Diseases
title_full_unstemmed Dysregulated miRNAs as Biomarkers and Therapeutical Targets in Neurodegenerative Diseases
title_short Dysregulated miRNAs as Biomarkers and Therapeutical Targets in Neurodegenerative Diseases
title_sort dysregulated mirnas as biomarkers and therapeutical targets in neurodegenerative diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143965/
https://www.ncbi.nlm.nih.gov/pubmed/35629192
http://dx.doi.org/10.3390/jpm12050770
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