Different Effects of RNAi-Mediated Downregulation or Chemical Inhibition of NAMPT in an Isogenic IDH Mutant and Wild-Type Glioma Cell Model

The IDH1(R132H) mutation in glioma results in the neoenzymatic function of IDH1, leading to the production of the oncometabolite 2-hydroxyglutarate (2-HG), alterations in energy metabolism and changes in the cellular redox household. Although shifts in the redox ratio NADPH/NADP(+) were described, t...

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Detalles Bibliográficos
Autores principales: Clausing, Maximilian, William, Doreen, Preussler, Matthias, Biedermann, Julia, Grützmann, Konrad, Richter, Susan, Buchholz, Frank, Temme, Achim, Schröck, Evelin, Klink, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143996/
https://www.ncbi.nlm.nih.gov/pubmed/35628596
http://dx.doi.org/10.3390/ijms23105787

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