Endothelial expression of human amyloid precursor protein leads to amyloid β in the blood and induces cerebral amyloid angiopathy in knock-in mice

The deposition of amyloid β (Aβ) in blood vessels of the brain, known as cerebral amyloid angiopathy (CAA), is observed in most patients with Alzheimer’s disease (AD). Compared with the pathology of CAA in humans, the pathology in most mouse models of AD is not as evident, making it difficult to exa...

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Detalles Bibliográficos
Autores principales: Tachida, Yuriko, Miura, Saori, Muto, Yui, Takuwa, Hiroyuki, Sahara, Naruhiko, Shindo, Akihiro, Matsuba, Yukio, Saito, Takashi, Taniguchi, Naoyuki, Kawaguchi, Yasushi, Tomimoto, Hidekazu, Saido, Takaomi, Kitazume, Shinobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144051/
https://www.ncbi.nlm.nih.gov/pubmed/35367207
http://dx.doi.org/10.1016/j.jbc.2022.101880

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