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Mucormycosis and COVID-19-Associated Mucormycosis: Insights of a Deadly but Neglected Mycosis

The ongoing COVID-19 pandemic has quickly become a health threat worldwide, with high mortality and morbidity among patients with comorbidities. This viral infection promotes the perfect setting in patients for the development of opportunistic infections, such as those caused by fungi. Mucormycosis,...

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Autores principales: García-Carnero, Laura C., Mora-Montes, Héctor M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144279/
https://www.ncbi.nlm.nih.gov/pubmed/35628701
http://dx.doi.org/10.3390/jof8050445
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author García-Carnero, Laura C.
Mora-Montes, Héctor M.
author_facet García-Carnero, Laura C.
Mora-Montes, Héctor M.
author_sort García-Carnero, Laura C.
collection PubMed
description The ongoing COVID-19 pandemic has quickly become a health threat worldwide, with high mortality and morbidity among patients with comorbidities. This viral infection promotes the perfect setting in patients for the development of opportunistic infections, such as those caused by fungi. Mucormycosis, a rare but deadly fungal infection, has recently increased its incidence, especially in endemic areas, since the onset of the pandemic. COVID-19-associated mucormycosis is an important complication of the pandemic because it is a mycosis hard to diagnose and treat, causing concern among COVID-19-infected patients and even in the already recovered population. The risk factors for the development of mucormycosis in these patients are related to the damage caused by the SARS-CoV-2 itself, the patient’s overstimulated immune response, and the therapy used to treat COVID-19, causing alterations such as hyperglycemia, acidosis, endothelial and lung damage, and immunosuppression. In this review, the molecular aspects of mucormycosis and the main risk factors for the development of COVID-19-associated mucormycosis are explained to understand this virus–fungi–host interaction and highlight the importance of this neglected mycosis.
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spelling pubmed-91442792022-05-29 Mucormycosis and COVID-19-Associated Mucormycosis: Insights of a Deadly but Neglected Mycosis García-Carnero, Laura C. Mora-Montes, Héctor M. J Fungi (Basel) Review The ongoing COVID-19 pandemic has quickly become a health threat worldwide, with high mortality and morbidity among patients with comorbidities. This viral infection promotes the perfect setting in patients for the development of opportunistic infections, such as those caused by fungi. Mucormycosis, a rare but deadly fungal infection, has recently increased its incidence, especially in endemic areas, since the onset of the pandemic. COVID-19-associated mucormycosis is an important complication of the pandemic because it is a mycosis hard to diagnose and treat, causing concern among COVID-19-infected patients and even in the already recovered population. The risk factors for the development of mucormycosis in these patients are related to the damage caused by the SARS-CoV-2 itself, the patient’s overstimulated immune response, and the therapy used to treat COVID-19, causing alterations such as hyperglycemia, acidosis, endothelial and lung damage, and immunosuppression. In this review, the molecular aspects of mucormycosis and the main risk factors for the development of COVID-19-associated mucormycosis are explained to understand this virus–fungi–host interaction and highlight the importance of this neglected mycosis. MDPI 2022-04-25 /pmc/articles/PMC9144279/ /pubmed/35628701 http://dx.doi.org/10.3390/jof8050445 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
García-Carnero, Laura C.
Mora-Montes, Héctor M.
Mucormycosis and COVID-19-Associated Mucormycosis: Insights of a Deadly but Neglected Mycosis
title Mucormycosis and COVID-19-Associated Mucormycosis: Insights of a Deadly but Neglected Mycosis
title_full Mucormycosis and COVID-19-Associated Mucormycosis: Insights of a Deadly but Neglected Mycosis
title_fullStr Mucormycosis and COVID-19-Associated Mucormycosis: Insights of a Deadly but Neglected Mycosis
title_full_unstemmed Mucormycosis and COVID-19-Associated Mucormycosis: Insights of a Deadly but Neglected Mycosis
title_short Mucormycosis and COVID-19-Associated Mucormycosis: Insights of a Deadly but Neglected Mycosis
title_sort mucormycosis and covid-19-associated mucormycosis: insights of a deadly but neglected mycosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144279/
https://www.ncbi.nlm.nih.gov/pubmed/35628701
http://dx.doi.org/10.3390/jof8050445
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