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Heterogeneity of Blood Vessels and Assessment of Microvessel Density-MVD in Gingivitis
Gingivitis is a very common oral disease highly prevalent in adults that, if left untreated, can progress to periodontitis. It involves a complex and slow interaction between the host response and the oral microbiome represented by the dental plaque. The inflammation of the gingiva is associated wit...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144308/ https://www.ncbi.nlm.nih.gov/pubmed/35628885 http://dx.doi.org/10.3390/jcm11102758 |
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author | Roi, Ciprian Gaje, Pușa Nela Ceaușu, Raluca Amalia Roi, Alexandra Rusu, Laura Cristina Boia, Eugen Radu Boia, Simina Luca, Ruxandra Elena Riviș, Mircea |
author_facet | Roi, Ciprian Gaje, Pușa Nela Ceaușu, Raluca Amalia Roi, Alexandra Rusu, Laura Cristina Boia, Eugen Radu Boia, Simina Luca, Ruxandra Elena Riviș, Mircea |
author_sort | Roi, Ciprian |
collection | PubMed |
description | Gingivitis is a very common oral disease highly prevalent in adults that, if left untreated, can progress to periodontitis. It involves a complex and slow interaction between the host response and the oral microbiome represented by the dental plaque. The inflammation of the gingiva is associated with the activation of pathological angiogenesis and the existence of a high number of newly formed blood vessels quantified as microvessel density (MVD). The present study includes a number of 51 gingival biopsies from patients with different gingival indexes (GI): GI = 0, n = 12; GI = 1, n = 15; GI = 2, n = 16; and GI = 3, n = 8, processed and stained with the routine hematoxylin–eosin method. The inflammatory infiltrate was scored, the blood vessels were detected with anti-CD34 antibody, and MVD was determined. Inflammatory changes were observed in 39 of the 51 cases included in our study. CD34 + vessels with normal morphological appearance were observed in all 12 cases of health gingiva. In cases of inflammatory lesions, the morphology of the blood vessels showed changes with the evolution of gingival lesions. In severe inflammation, a particular aspect was observed in the vessels, such as the presence of the phenomenon of intussusception. MVD increases with the severity of gingival lesions, with the highest density being observed in severe inflammation. |
format | Online Article Text |
id | pubmed-9144308 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91443082022-05-29 Heterogeneity of Blood Vessels and Assessment of Microvessel Density-MVD in Gingivitis Roi, Ciprian Gaje, Pușa Nela Ceaușu, Raluca Amalia Roi, Alexandra Rusu, Laura Cristina Boia, Eugen Radu Boia, Simina Luca, Ruxandra Elena Riviș, Mircea J Clin Med Article Gingivitis is a very common oral disease highly prevalent in adults that, if left untreated, can progress to periodontitis. It involves a complex and slow interaction between the host response and the oral microbiome represented by the dental plaque. The inflammation of the gingiva is associated with the activation of pathological angiogenesis and the existence of a high number of newly formed blood vessels quantified as microvessel density (MVD). The present study includes a number of 51 gingival biopsies from patients with different gingival indexes (GI): GI = 0, n = 12; GI = 1, n = 15; GI = 2, n = 16; and GI = 3, n = 8, processed and stained with the routine hematoxylin–eosin method. The inflammatory infiltrate was scored, the blood vessels were detected with anti-CD34 antibody, and MVD was determined. Inflammatory changes were observed in 39 of the 51 cases included in our study. CD34 + vessels with normal morphological appearance were observed in all 12 cases of health gingiva. In cases of inflammatory lesions, the morphology of the blood vessels showed changes with the evolution of gingival lesions. In severe inflammation, a particular aspect was observed in the vessels, such as the presence of the phenomenon of intussusception. MVD increases with the severity of gingival lesions, with the highest density being observed in severe inflammation. MDPI 2022-05-13 /pmc/articles/PMC9144308/ /pubmed/35628885 http://dx.doi.org/10.3390/jcm11102758 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Roi, Ciprian Gaje, Pușa Nela Ceaușu, Raluca Amalia Roi, Alexandra Rusu, Laura Cristina Boia, Eugen Radu Boia, Simina Luca, Ruxandra Elena Riviș, Mircea Heterogeneity of Blood Vessels and Assessment of Microvessel Density-MVD in Gingivitis |
title | Heterogeneity of Blood Vessels and Assessment of Microvessel Density-MVD in Gingivitis |
title_full | Heterogeneity of Blood Vessels and Assessment of Microvessel Density-MVD in Gingivitis |
title_fullStr | Heterogeneity of Blood Vessels and Assessment of Microvessel Density-MVD in Gingivitis |
title_full_unstemmed | Heterogeneity of Blood Vessels and Assessment of Microvessel Density-MVD in Gingivitis |
title_short | Heterogeneity of Blood Vessels and Assessment of Microvessel Density-MVD in Gingivitis |
title_sort | heterogeneity of blood vessels and assessment of microvessel density-mvd in gingivitis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144308/ https://www.ncbi.nlm.nih.gov/pubmed/35628885 http://dx.doi.org/10.3390/jcm11102758 |
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